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The G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Sciences (PIBOC FEB RAS) was founded in 1964 in Vladivostok in the Far East of Russia. Over many years, we have been carrying out studies on the natural products of both marine and terrestrial origin. In collaboration with many Russian and foreign scientists, we have investigated many hundreds of diverse biomolecules, including steroids and terpenoids, quinoid compounds and alkaloids, polysaccharides and lipids, enzymes and lectins, proteins, and peptides. The Institute has a collection of marine microorganisms (KMM) PIBOC, which includes more than 4000 strains of marine bacteria and more than 1000 strains of marine fungi. The biological activity of natural compounds is also being studied. This book includes the 14 manuscripts which covered almost all aspects of PIBOC research activity in the fields of bioorganic chemistry, biochemistry, organic synthesis of natural compounds, marine microbiology, and genetic engineering, and we hope it will provide interesting new information for scientists working in these fields.

Research & information: general --- polyhydroxylated steroids --- NMR spectra --- starfish --- Anthenoides laevigatus --- cytotoxicity --- soft agar assay --- kainic acid --- domoic acid --- dysiherbaine --- neodysiherbaine A --- marine bacteria --- whole genome sequence --- porin --- amino acids composition --- bilayer lipid membrane --- pore-forming activity --- spatial structure --- phlorotannins --- phlorethols --- anticancer activity --- colorectal cancer --- radiosensitizer --- radiotherapy --- 1,4-naphthoquinones --- quinoid compounds --- thioglycosides --- quinone-sugar conjugates --- cytotoxic activity --- antibiotic activity --- histochrome --- echinochrome A --- oxidative degradation --- HPLC–DAD–MS --- NMR --- actinoporin --- sea anemone --- Heteractis crispa --- anti-migratory activity --- glycosphingolipids --- cerebrosides --- peroxidation products --- structure elucidation --- allylic thioether --- ESI-MS --- GC-MS --- mass spectra --- glass sponge --- isomalabaricanes --- Stelletta sp. --- marine sponge --- terpenoid --- Cobetia amphilecti --- Cobetia litoralis --- Cobetia pacifica --- Cobetia marina --- Cobetia crustatorum --- identification markers --- alkaline phosphatase PhoA --- lanosterol 14-alpha demethylase --- flavonoids --- enzyme inhibition --- surface plasmon resonance --- spectral titration --- molecular docking --- Zobellia --- genomes --- polysaccharide lyase family 7 --- alginate utilization system --- paralogs --- orthologs --- recombinant phospholipase A1 --- Yersinia pseudotuberculosis --- inclusion bodies --- fusion protein --- green fluorescent protein --- porin gene expression --- antibiotic stress --- phenotypic heterogeneity --- n/a --- HPLC-DAD-MS

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The G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Sciences (PIBOC FEB RAS) was founded in 1964 in Vladivostok in the Far East of Russia. Over many years, we have been carrying out studies on the natural products of both marine and terrestrial origin. In collaboration with many Russian and foreign scientists, we have investigated many hundreds of diverse biomolecules, including steroids and terpenoids, quinoid compounds and alkaloids, polysaccharides and lipids, enzymes and lectins, proteins, and peptides. The Institute has a collection of marine microorganisms (KMM) PIBOC, which includes more than 4000 strains of marine bacteria and more than 1000 strains of marine fungi. The biological activity of natural compounds is also being studied. This book includes the 14 manuscripts which covered almost all aspects of PIBOC research activity in the fields of bioorganic chemistry, biochemistry, organic synthesis of natural compounds, marine microbiology, and genetic engineering, and we hope it will provide interesting new information for scientists working in these fields.

Research & information: general --- polyhydroxylated steroids --- NMR spectra --- starfish --- Anthenoides laevigatus --- cytotoxicity --- soft agar assay --- kainic acid --- domoic acid --- dysiherbaine --- neodysiherbaine A --- marine bacteria --- whole genome sequence --- porin --- amino acids composition --- bilayer lipid membrane --- pore-forming activity --- spatial structure --- phlorotannins --- phlorethols --- anticancer activity --- colorectal cancer --- radiosensitizer --- radiotherapy --- 1,4-naphthoquinones --- quinoid compounds --- thioglycosides --- quinone-sugar conjugates --- cytotoxic activity --- antibiotic activity --- histochrome --- echinochrome A --- oxidative degradation --- HPLC-DAD-MS --- NMR --- actinoporin --- sea anemone --- Heteractis crispa --- anti-migratory activity --- glycosphingolipids --- cerebrosides --- peroxidation products --- structure elucidation --- allylic thioether --- ESI-MS --- GC-MS --- mass spectra --- glass sponge --- isomalabaricanes --- Stelletta sp. --- marine sponge --- terpenoid --- Cobetia amphilecti --- Cobetia litoralis --- Cobetia pacifica --- Cobetia marina --- Cobetia crustatorum --- identification markers --- alkaline phosphatase PhoA --- lanosterol 14-alpha demethylase --- flavonoids --- enzyme inhibition --- surface plasmon resonance --- spectral titration --- molecular docking --- Zobellia --- genomes --- polysaccharide lyase family 7 --- alginate utilization system --- paralogs --- orthologs --- recombinant phospholipase A1 --- Yersinia pseudotuberculosis --- inclusion bodies --- fusion protein --- green fluorescent protein --- porin gene expression --- antibiotic stress --- phenotypic heterogeneity

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This Special Issue of Marine Drugs, entitled “Bioactive Marine Heterocyclic Compounds”, aimed to collect excellent original research articles and reviews focused on the isolation of new heterocyclic marine natural products, total synthesis, synthetic modification, or on finding important bioactivities of known heterocyclic marine natural products. As a result, five original papers on isolation and one synthetic study of metabolites from marine-derived bioorganisms or a marine sponge, along with one review paper on thiazole-based peptides, were published. I am proud to show these most recent works of outstanding scientists in this field and hope this Special issue will affect new drug developments or innovation in the future.

altercrasins --- Alternaria sp. --- Anthocidaris crassispina --- decalin derivatives --- cytotoxicity --- mangrove plant --- endophytic fungus --- Cladosporium cladosporioides --- polyketides --- antimicrobial activity --- acetylcholinesterase --- enzymatic inhibitory activity --- genome sequencing --- gene disruption --- lobophorin --- metabolic engineering --- genome mining --- solid-state fermentation --- solid-state extraction --- Chrysosporium lobatum --- marine fungi --- phenalenone derivatives --- antibiotics --- natural product --- P. gingivalis --- methicillin-resistant S. aureus --- azole-based peptide --- marine sponge --- peptide synthesis --- cyanobacteria --- thiazole --- bioactivity --- agesasines --- bromopyrrole alkaloid --- Agelas

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This book describes the recent advances in natural product chemistry and biodiversity in the Red Sea. All previous marine natural products isolated from different Red Sea organisms and microbes were collected in a comprehensive review. Additionally, newly discovered marine natural products and their biological activities are described.

Research & information: general --- Aspergillus falconensis --- OSMAC --- azaphilones --- X-ray diffraction --- NF-κB inhibition --- LC-HRESIMS --- Stylissa carteri --- ceramide --- cerebroside --- docking --- cytotoxic activity --- co-cultivation --- phenazine --- sponge-associated actinomycetes --- antibacterial --- antibiofilm --- DNA gyrase --- pyruvate kinase --- ergosterol derivative --- metabolic analysis --- docking studies --- seagrass --- Thalassodendron ciliatum --- Red Sea sponges --- marine actinomycetes --- Streptomyces coelicolor LY001 --- halogenated 3-phenylpropanoic acid derivatives --- diketopiperazine alkaloids --- structural determinations --- antimicrobial activities --- Red Sea --- marine natural products --- marine organisms --- biodiversity --- marine metagenomics --- bioactivity --- Sinularia polydactyla --- soft coral --- steroids --- cytotoxic --- anti-inflammatory --- neuroprotective --- androgen receptor --- Actinokineospora --- Rhodococcus --- co-culture --- metabolomics --- antimalarial --- epicotripeptin --- phragamide --- Epicoccum --- Alternaria --- antimicrobial --- n/a

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Taking the papers’ collection of this Special Issue as a whole, it is clear that “Municipal Wastewater Management” is an ongoing field of research with the ability to incorporate current environmental and human health challenges. The use of municipal sewage to monitor COVID-19 virus circulation in communities and the estimation of possible outbreaks, even before clinical cases have been identified, is a fact that justifies this. In light of the Coronavirus pandemic, the interest of the impact that research on municipal wastewater management can have on improving humans’ health and protecting the environment is being rethought. In respect to this, there is an essential need for scientific publications that present varieties of case studies and discuss best practices, so as wastewater treatment plants to be seen not only as sites of pollutants removal but also as places where energy is efficiently used and environmental sustainability is being practiced, in close relation to the needs of the community. Viewed in this way, the papers’ collected in this Special Issue are looking forward to reach a broad readership that can gain awareness and understanding of their topics and be stimulated into future research and collaborations that would improve all stakeholders engagement in promoting a sustainable municipal wastewater management.

sewer corrosion --- biocorrosion --- concrete sewers --- ocean dumping --- sewage sludge --- capping method --- London Protocol --- least cost analysis --- integrated fixed-film activated sludge systems --- modified loofah sponge --- bio-carrier --- microbial density --- municipal wastewater --- Greece --- wastewater treatment plant (WWTP) --- history --- policy --- technology trends and applications --- microorganisms --- inactivation --- water matrix --- catalysts --- antibiotic-resistant bacteria --- resistance genes --- heterogeneous catalytic ozonation --- PZC --- p-CBA --- minerals --- thermal treatment --- micropollutants removal --- hybrid constructed wetland --- public acceptance --- wastewater reuse --- wastewater treatment --- waste-water management --- SCADA --- design optimization --- remote control --- IoT --- cloud computing --- disruptive innovation --- lifecycle --- water prices --- water tariffs --- sanitation taxes --- wastewater treatment costs --- energy costs --- household budgets --- screenings --- fats --- biogas potential --- wastewater treatment plant --- energy utilization --- anaerobic digestion --- n/a