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This book has been written with the purpose of providing a vision of a topic which is on the edge of biology and chemistry. As well, we want to provide an updated vision of the potentials and limitations of biocatalysis, especially with respect to applications in processes of organic synthesis, fine chemicals, and medicine. This book pretends to illustrate the potential of an excellent overview of recent progress on the assessment of granted patents as a useful tool in asymmetric synthesis. Some distinguished researchers have contributed to this endeavor with their knowledge, their commitment and their encouragement
Research & information: general --- ferulic acid esters --- octyl ferulate --- esterification --- Box-Behnken design --- response surface methodology --- molar conversion --- optimum condition --- Bacillus --- glycosyltransferase --- 8-hydroxydaidzein --- industrial biotechnology --- electrochemistry --- biohydrogen --- biocatalysis --- process development --- bacteria --- Enantioselectivity --- enzyme cascade --- hydroxynitrile lyase --- lipase --- hydrocyanation --- transesterification --- glycosidases --- transglycosylation --- cyclodextrin glycosyltransferases --- alkyl glucosides --- biosurfactants --- MDR-medium-chain reductase/dehydrogenase --- ADH-alcohol dehydrogenase --- enzyme kinetics --- EDTA (Ethylenediaminetetraacetic acid) chelation --- ultrafiltration --- pseudokinases --- signal transduction --- cancer therapy --- tyrosine/serine/threonine phosphorylation --- new drug targets --- interactome --- asymmetric synthesis --- patents --- lipases --- oxidoreductases --- lyases --- transaminases --- ferulic acid esters --- octyl ferulate --- esterification --- Box-Behnken design --- response surface methodology --- molar conversion --- optimum condition --- Bacillus --- glycosyltransferase --- 8-hydroxydaidzein --- industrial biotechnology --- electrochemistry --- biohydrogen --- biocatalysis --- process development --- bacteria --- Enantioselectivity --- enzyme cascade --- hydroxynitrile lyase --- lipase --- hydrocyanation --- transesterification --- glycosidases --- transglycosylation --- cyclodextrin glycosyltransferases --- alkyl glucosides --- biosurfactants --- MDR-medium-chain reductase/dehydrogenase --- ADH-alcohol dehydrogenase --- enzyme kinetics --- EDTA (Ethylenediaminetetraacetic acid) chelation --- ultrafiltration --- pseudokinases --- signal transduction --- cancer therapy --- tyrosine/serine/threonine phosphorylation --- new drug targets --- interactome --- asymmetric synthesis --- patents --- lipases --- oxidoreductases --- lyases --- transaminases
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This book has been written with the purpose of providing a vision of a topic which is on the edge of biology and chemistry. As well, we want to provide an updated vision of the potentials and limitations of biocatalysis, especially with respect to applications in processes of organic synthesis, fine chemicals, and medicine. This book pretends to illustrate the potential of an excellent overview of recent progress on the assessment of granted patents as a useful tool in asymmetric synthesis. Some distinguished researchers have contributed to this endeavor with their knowledge, their commitment and their encouragement
Research & information: general --- ferulic acid esters --- octyl ferulate --- esterification --- Box-Behnken design --- response surface methodology --- molar conversion --- optimum condition --- Bacillus --- glycosyltransferase --- 8-hydroxydaidzein --- industrial biotechnology --- electrochemistry --- biohydrogen --- biocatalysis --- process development --- bacteria --- Enantioselectivity --- enzyme cascade --- hydroxynitrile lyase --- lipase --- hydrocyanation --- transesterification --- glycosidases --- transglycosylation --- cyclodextrin glycosyltransferases --- alkyl glucosides --- biosurfactants --- MDR—medium-chain reductase/dehydrogenase --- ADH—alcohol dehydrogenase --- enzyme kinetics --- EDTA (Ethylenediaminetetraacetic acid) chelation --- ultrafiltration --- pseudokinases --- signal transduction --- cancer therapy --- tyrosine/serine/threonine phosphorylation --- new drug targets --- interactome --- asymmetric synthesis --- patents --- lipases --- oxidoreductases --- lyases --- transaminases --- n/a --- MDR-medium-chain reductase/dehydrogenase --- ADH-alcohol dehydrogenase
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p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity.
arginine methylation --- erythroid differentiation --- MKK3 --- phosphorylation, PRMT1 --- p38 MAPK --- cocaine --- conditioned place preference --- reward --- stress --- anxiety --- depression --- nucleus accumbens --- social interaction --- k opioid receptors --- p38α --- Rab5 --- endosome --- Alzheimer’s --- Lewy Bodies --- amyloid-β --- tau --- α-synuclein --- p38-MAPK α inhibitor --- Alzheimer’s disease --- synaptic plasticity --- neuroinflammation --- β-amyloid --- Tau --- Kv4.2 --- seizure --- temporal lobe epilepsy --- hippocampus --- neuronal firing and excitability --- p38MAPK --- nuclear translocation --- β-like importins --- inflammation --- cancer --- skeletal muscle --- energy metabolism --- signal transduction --- exercise --- type 2 diabetes --- p38 mitogen-activated protein kinase --- bleomycin-induced pulmonary fibrosis --- idiopathic pulmonary fibrosis --- RNA sequencing --- alveolar epithelial type II cells --- MAPK --- p38 --- physiology --- metabolism --- signaling --- hypoxia --- arrhythmia --- MAPK11 --- p38β --- n/a --- Alzheimer's --- Alzheimer's disease
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This book has been written with the purpose of providing a vision of a topic which is on the edge of biology and chemistry. As well, we want to provide an updated vision of the potentials and limitations of biocatalysis, especially with respect to applications in processes of organic synthesis, fine chemicals, and medicine. This book pretends to illustrate the potential of an excellent overview of recent progress on the assessment of granted patents as a useful tool in asymmetric synthesis. Some distinguished researchers have contributed to this endeavor with their knowledge, their commitment and their encouragement
ferulic acid esters --- octyl ferulate --- esterification --- Box-Behnken design --- response surface methodology --- molar conversion --- optimum condition --- Bacillus --- glycosyltransferase --- 8-hydroxydaidzein --- industrial biotechnology --- electrochemistry --- biohydrogen --- biocatalysis --- process development --- bacteria --- Enantioselectivity --- enzyme cascade --- hydroxynitrile lyase --- lipase --- hydrocyanation --- transesterification --- glycosidases --- transglycosylation --- cyclodextrin glycosyltransferases --- alkyl glucosides --- biosurfactants --- MDR—medium-chain reductase/dehydrogenase --- ADH—alcohol dehydrogenase --- enzyme kinetics --- EDTA (Ethylenediaminetetraacetic acid) chelation --- ultrafiltration --- pseudokinases --- signal transduction --- cancer therapy --- tyrosine/serine/threonine phosphorylation --- new drug targets --- interactome --- asymmetric synthesis --- patents --- lipases --- oxidoreductases --- lyases --- transaminases --- n/a --- MDR-medium-chain reductase/dehydrogenase --- ADH-alcohol dehydrogenase
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p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity.
Research & information: general --- arginine methylation --- erythroid differentiation --- MKK3 --- phosphorylation, PRMT1 --- p38 MAPK --- cocaine --- conditioned place preference --- reward --- stress --- anxiety --- depression --- nucleus accumbens --- social interaction --- k opioid receptors --- p38α --- Rab5 --- endosome --- Alzheimer's --- Lewy Bodies --- amyloid-β --- tau --- α-synuclein --- p38-MAPK α inhibitor --- Alzheimer's disease --- synaptic plasticity --- neuroinflammation --- β-amyloid --- Tau --- Kv4.2 --- seizure --- temporal lobe epilepsy --- hippocampus --- neuronal firing and excitability --- p38MAPK --- nuclear translocation --- β-like importins --- inflammation --- cancer --- skeletal muscle --- energy metabolism --- signal transduction --- exercise --- type 2 diabetes --- p38 mitogen-activated protein kinase --- bleomycin-induced pulmonary fibrosis --- idiopathic pulmonary fibrosis --- RNA sequencing --- alveolar epithelial type II cells --- MAPK --- p38 --- physiology --- metabolism --- signaling --- hypoxia --- arrhythmia --- MAPK11 --- p38β --- arginine methylation --- erythroid differentiation --- MKK3 --- phosphorylation, PRMT1 --- p38 MAPK --- cocaine --- conditioned place preference --- reward --- stress --- anxiety --- depression --- nucleus accumbens --- social interaction --- k opioid receptors --- p38α --- Rab5 --- endosome --- Alzheimer's --- Lewy Bodies --- amyloid-β --- tau --- α-synuclein --- p38-MAPK α inhibitor --- Alzheimer's disease --- synaptic plasticity --- neuroinflammation --- β-amyloid --- Tau --- Kv4.2 --- seizure --- temporal lobe epilepsy --- hippocampus --- neuronal firing and excitability --- p38MAPK --- nuclear translocation --- β-like importins --- inflammation --- cancer --- skeletal muscle --- energy metabolism --- signal transduction --- exercise --- type 2 diabetes --- p38 mitogen-activated protein kinase --- bleomycin-induced pulmonary fibrosis --- idiopathic pulmonary fibrosis --- RNA sequencing --- alveolar epithelial type II cells --- MAPK --- p38 --- physiology --- metabolism --- signaling --- hypoxia --- arrhythmia --- MAPK11 --- p38β
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“Symmetry Breaking in Cells and Tissues” presents a collection of seventeen reviews, opinions and original research papers contributed by theoreticians, physicists and mathematicians, as well as experimental biologists, united by a common interest in biological pattern formation and morphogenesis. The contributors discuss diverse manifestations of symmetry breaking in biology and showcase recent developments in experimental and theoretical approaches to biological morphogenesis and pattern formation on multiple scales.
Research & information: general --- Biology, life sciences --- actin waves --- curved proteins --- dynamic instability --- podosomes --- diffusion --- cell polarity --- Cdc42 --- stress --- cellular memory --- phase separation --- prions --- apoptotic extrusion --- oncogenic extrusion --- contractility --- actomyosin --- bottom-up synthetic biology --- motor proteins --- pattern formation --- self-organization --- cell motility --- signal transduction --- actin dynamics --- intracellular waves --- polarization --- direction sensing --- symmetry-breaking --- biphasic responses --- reaction-diffusion --- membrane and cortical tension --- cell fusion --- cortexillin --- cytokinesis --- Dictyostelium --- myosin --- symmetry breaking --- cytoplasmic flow --- phase-space analysis --- nonlinear waves --- actin polymerization --- bifurcation theory --- mass conservation --- spatial localization --- activator–inhibitor models --- developmental transitions --- cell polarization --- mathematical model --- fission yeast --- reaction–diffusion model --- small GTPases --- Cdc42 oscillations --- pseudopod --- Ras activation --- cytoskeleton --- chemotaxis --- neutrophils --- natural variation --- modelling --- activator-substrate mechanism --- mass-conserved models --- intracellular polarization --- partial differential equations --- sensitivity analysis --- GTPase activating protein (GAP) --- fission yeast Schizosaccharomyces pombe --- CRY2-CIBN --- optogenetics --- clustering --- positive feedback --- network evolution --- Saccharomyces cerevisiae --- polarity --- modularity --- neutrality --- n/a
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“Symmetry Breaking in Cells and Tissues” presents a collection of seventeen reviews, opinions and original research papers contributed by theoreticians, physicists and mathematicians, as well as experimental biologists, united by a common interest in biological pattern formation and morphogenesis. The contributors discuss diverse manifestations of symmetry breaking in biology and showcase recent developments in experimental and theoretical approaches to biological morphogenesis and pattern formation on multiple scales.
actin waves --- curved proteins --- dynamic instability --- podosomes --- diffusion --- cell polarity --- Cdc42 --- stress --- cellular memory --- phase separation --- prions --- apoptotic extrusion --- oncogenic extrusion --- contractility --- actomyosin --- bottom-up synthetic biology --- motor proteins --- pattern formation --- self-organization --- cell motility --- signal transduction --- actin dynamics --- intracellular waves --- polarization --- direction sensing --- symmetry-breaking --- biphasic responses --- reaction-diffusion --- membrane and cortical tension --- cell fusion --- cortexillin --- cytokinesis --- Dictyostelium --- myosin --- symmetry breaking --- cytoplasmic flow --- phase-space analysis --- nonlinear waves --- actin polymerization --- bifurcation theory --- mass conservation --- spatial localization --- activator–inhibitor models --- developmental transitions --- cell polarization --- mathematical model --- fission yeast --- reaction–diffusion model --- small GTPases --- Cdc42 oscillations --- pseudopod --- Ras activation --- cytoskeleton --- chemotaxis --- neutrophils --- natural variation --- modelling --- activator-substrate mechanism --- mass-conserved models --- intracellular polarization --- partial differential equations --- sensitivity analysis --- GTPase activating protein (GAP) --- fission yeast Schizosaccharomyces pombe --- CRY2-CIBN --- optogenetics --- clustering --- positive feedback --- network evolution --- Saccharomyces cerevisiae --- polarity --- modularity --- neutrality --- n/a
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The practice of regular physical activity has been proposed as a determinant in many disciplines, from wellness to physiotherapy; in fact, it reduces the risks of cardiovascular diseases and diabetes. Moreover, physical exercise decreases the incidence of some types of cancer, such as breast and colon cancer. Finally, rehabilitation protocols need correct exercise training to reach the complete “return to play” of patients. Unfortunately, the mechanisms associated with the beneficial effects of physical activity are still under study. Therefore, advances in all aspects of sport and exercise medicine will be relevant for physicians, recreational sport practitioners and elite athletes. This was the aim of this Special Issue, “New trends in sport and exercise medicine”, which achieved great success. Sixteen papers have been published, which are briefly described below. They range from mobile applications in physiotherapy to changes in bioactive lipids in half-marathoners. However, sport and exercise medicine are broad subjects and require more papers to clarify their different aspects. Therefore, we proposed a new Special Issue to continue on this path and gain new insights into sport and exercise medicine.
Medicine --- rehabilitation --- compliance --- anterior cruciate ligament reconstruction (ACLR) --- range of motion (ROM) --- self-efficacy --- behavioral design --- gamification --- microparticles --- microvesicles --- extracellular vesicles --- molecular markers --- cell-cell communication --- physical exercise --- physical activity --- angiogenesis --- secretome --- paracrine signaling --- cellular crosstalk --- ginseng --- performance --- recovery --- eccentric exercise --- inflammation --- allometry --- standing broad jump --- children --- growth --- maturity offset --- bench pull --- vertical jump --- power --- talent detection --- training --- insertional Achilles tendinopathy --- Achilles tendon moment arm --- suture bridge method --- cool-down strategy --- heart rate --- fatigue perception --- muscle strain --- quadriceps --- football --- invasive physiotherapy --- post-injury performance --- reinjury --- return to play --- autonomic nervous system --- cardiac autonomic regulation --- cardiorespiratory fitness --- daily training --- endurance --- secreted protein acidic and rich in cysteine (Sparc) --- exercise --- muscle performance --- metabolic phenotype --- lactate --- ageing --- high-impact weight-bearing exercise --- bone mineral density --- bone metabolic markers --- serum 25-(OH) D --- middle-aged premenopausal women --- ROS --- signal transduction --- aging --- air pollution --- lungs --- skeletal muscle mass --- muscular strength --- anaerobic power --- arterial stiffness --- cholinesterases --- heart rate variability --- autonomic recovery mechanisms --- sympathetic-parasympathetic modulation --- postexercise recovery --- ceramides --- cytokines --- diacylglycerol --- biomarkers --- rehabilitation --- compliance --- anterior cruciate ligament reconstruction (ACLR) --- range of motion (ROM) --- self-efficacy --- behavioral design --- gamification --- microparticles --- microvesicles --- extracellular vesicles --- molecular markers --- cell-cell communication --- physical exercise --- physical activity --- angiogenesis --- secretome --- paracrine signaling --- cellular crosstalk --- ginseng --- performance --- recovery --- eccentric exercise --- inflammation --- allometry --- standing broad jump --- children --- growth --- maturity offset --- bench pull --- vertical jump --- power --- talent detection --- training --- insertional Achilles tendinopathy --- Achilles tendon moment arm --- suture bridge method --- cool-down strategy --- heart rate --- fatigue perception --- muscle strain --- quadriceps --- football --- invasive physiotherapy --- post-injury performance --- reinjury --- return to play --- autonomic nervous system --- cardiac autonomic regulation --- cardiorespiratory fitness --- daily training --- endurance --- secreted protein acidic and rich in cysteine (Sparc) --- exercise --- muscle performance --- metabolic phenotype --- lactate --- ageing --- high-impact weight-bearing exercise --- bone mineral density --- bone metabolic markers --- serum 25-(OH) D --- middle-aged premenopausal women --- ROS --- signal transduction --- aging --- air pollution --- lungs --- skeletal muscle mass --- muscular strength --- anaerobic power --- arterial stiffness --- cholinesterases --- heart rate variability --- autonomic recovery mechanisms --- sympathetic-parasympathetic modulation --- postexercise recovery --- ceramides --- cytokines --- diacylglycerol --- biomarkers
Choose an application
“Symmetry Breaking in Cells and Tissues” presents a collection of seventeen reviews, opinions and original research papers contributed by theoreticians, physicists and mathematicians, as well as experimental biologists, united by a common interest in biological pattern formation and morphogenesis. The contributors discuss diverse manifestations of symmetry breaking in biology and showcase recent developments in experimental and theoretical approaches to biological morphogenesis and pattern formation on multiple scales.
Research & information: general --- Biology, life sciences --- actin waves --- curved proteins --- dynamic instability --- podosomes --- diffusion --- cell polarity --- Cdc42 --- stress --- cellular memory --- phase separation --- prions --- apoptotic extrusion --- oncogenic extrusion --- contractility --- actomyosin --- bottom-up synthetic biology --- motor proteins --- pattern formation --- self-organization --- cell motility --- signal transduction --- actin dynamics --- intracellular waves --- polarization --- direction sensing --- symmetry-breaking --- biphasic responses --- reaction-diffusion --- membrane and cortical tension --- cell fusion --- cortexillin --- cytokinesis --- Dictyostelium --- myosin --- symmetry breaking --- cytoplasmic flow --- phase-space analysis --- nonlinear waves --- actin polymerization --- bifurcation theory --- mass conservation --- spatial localization --- activator–inhibitor models --- developmental transitions --- cell polarization --- mathematical model --- fission yeast --- reaction–diffusion model --- small GTPases --- Cdc42 oscillations --- pseudopod --- Ras activation --- cytoskeleton --- chemotaxis --- neutrophils --- natural variation --- modelling --- activator-substrate mechanism --- mass-conserved models --- intracellular polarization --- partial differential equations --- sensitivity analysis --- GTPase activating protein (GAP) --- fission yeast Schizosaccharomyces pombe --- CRY2-CIBN --- optogenetics --- clustering --- positive feedback --- network evolution --- Saccharomyces cerevisiae --- polarity --- modularity --- neutrality --- actin waves --- curved proteins --- dynamic instability --- podosomes --- diffusion --- cell polarity --- Cdc42 --- stress --- cellular memory --- phase separation --- prions --- apoptotic extrusion --- oncogenic extrusion --- contractility --- actomyosin --- bottom-up synthetic biology --- motor proteins --- pattern formation --- self-organization --- cell motility --- signal transduction --- actin dynamics --- intracellular waves --- polarization --- direction sensing --- symmetry-breaking --- biphasic responses --- reaction-diffusion --- membrane and cortical tension --- cell fusion --- cortexillin --- cytokinesis --- Dictyostelium --- myosin --- symmetry breaking --- cytoplasmic flow --- phase-space analysis --- nonlinear waves --- actin polymerization --- bifurcation theory --- mass conservation --- spatial localization --- activator–inhibitor models --- developmental transitions --- cell polarization --- mathematical model --- fission yeast --- reaction–diffusion model --- small GTPases --- Cdc42 oscillations --- pseudopod --- Ras activation --- cytoskeleton --- chemotaxis --- neutrophils --- natural variation --- modelling --- activator-substrate mechanism --- mass-conserved models --- intracellular polarization --- partial differential equations --- sensitivity analysis --- GTPase activating protein (GAP) --- fission yeast Schizosaccharomyces pombe --- CRY2-CIBN --- optogenetics --- clustering --- positive feedback --- network evolution --- Saccharomyces cerevisiae --- polarity --- modularity --- neutrality
Listing 1 - 10 of 14 | << page >> |
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