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In this Special Issue, we focus on maternal docosahexaenoic acid, 22:6n-3 (DHA), and arachidonic acid, 20:4n-6 (ARA), on children’s neurodevelopment. During the last trimester of gestation and for the first 18 months after birth, both DHA and ARA are preferentially deposited within the cerebral cortex at a rapid rate. The mode of action of these two fatty acids and their derivatives at different structural–functional roles, and their levels in the signaling pathways of the brain have been continuously studied. These fatty acids are also involved in various brain developmental processes; however, their mechanistic cross talks are not yet clearly known. Recent data suggest that there may be a need for a balanced proportion of ARA and DHA in infant formula due to their complementary benefits. This review describes the importance of ARA in addition to DHA to support optimal brain development and growth in an infant, and functional roles in the brain.

maternal supplementation --- pregnancy --- lactation --- docosahexaenoic acid (DHA) --- neurodevelopment --- randomized controlled trial (RCT) --- India --- DHA --- brain --- MFSD2a --- SPM --- fetus --- placenta --- infant --- neurogenesis --- pre-term --- docosahexaenoic acid --- supplementation --- egg yolk --- microalgae --- long chain omega-3 fatty acids --- pregnancy outcomes --- anthropometry --- birth weight --- birth length --- head circumference --- arachidonic acid,20:4n-6 --- docosahexaenoic acid,22:6n-3 --- maternal diet --- cognitive --- infants --- n/a

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Nutritional epidemiology examines dietary or nutritional factors in relation to the occurrence of disease in various populations. It is a fact that substantial progress has been made in recent years in nutritional epidemiology. Compared to the practice during the 1990s, and with the improvements in data analytics, several new approaches are gaining ground. Results from a variety of large-scale studies in the field of nutrition epidemiology have substantially contributed toward the evidence used in guiding dietary recommendations for the prevention of cardiovascular diseases, metabolic disorders, some types of cancer, and other morbidities. In this Special Issue, we would like to bring readers closer to the state-of-the-art in the field by gathering papers covering different aspects of nutrition epidemiology from population-based observational studies. Topics of the submitted articles may, but not necessarily, include eating habits of various populations, especially of those not well-studied, such as in Africa, Oceania, South Americas, immigrants, minorities, as well as a variety of associations between nutrients/foods/food patterns and chronic diseases, like cardiovascular, diabetes, obesity, cancer, etc., and gene–nutrient and epigenome–nutrient interactions related to human health at all ages.

Research & information: general --- Biology, life sciences --- Food & society --- healthy diet indexes --- food intake --- apulia --- mind index --- dash index --- med-diet score --- dietary patterns --- eating restrictions --- food involvement --- adults --- obesity --- nutrition assessment --- diet survey --- dietary pattern analysis --- nutrient inadequacy --- overweight and obesity --- nutritional epidemiology --- nutrition transition --- pastoral nomadism --- Mongolia --- central Asia --- breakfast consumption --- breakfast composition --- children --- dietary intake --- dietary quality --- diet patterns --- cardiometabolic outcomes --- adiposity --- short-chain fatty acids --- BMI --- waist-to-height ratio --- fiber --- gut metagenome --- diet --- plant sterols --- stanols --- omega-3 fatty acids --- familial hypercholesterolemia --- nutritional status --- population survey --- oral frailty --- health behavior --- eating competence --- health outcomes --- validation --- questionnaire --- food consumption --- salty snack products --- students --- consumption --- salt intake --- health policies --- nutrition policies --- Europe --- primary care --- breakfast intake --- lifestyle behaviors --- sociodemographic factors --- healthy diet indexes --- food intake --- apulia --- mind index --- dash index --- med-diet score --- dietary patterns --- eating restrictions --- food involvement --- adults --- obesity --- nutrition assessment --- diet survey --- dietary pattern analysis --- nutrient inadequacy --- overweight and obesity --- nutritional epidemiology --- nutrition transition --- pastoral nomadism --- Mongolia --- central Asia --- breakfast consumption --- breakfast composition --- children --- dietary intake --- dietary quality --- diet patterns --- cardiometabolic outcomes --- adiposity --- short-chain fatty acids --- BMI --- waist-to-height ratio --- fiber --- gut metagenome --- diet --- plant sterols --- stanols --- omega-3 fatty acids --- familial hypercholesterolemia --- nutritional status --- population survey --- oral frailty --- health behavior --- eating competence --- health outcomes --- validation --- questionnaire --- food consumption --- salty snack products --- students --- consumption --- salt intake --- health policies --- nutrition policies --- Europe --- primary care --- breakfast intake --- lifestyle behaviors --- sociodemographic factors

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Dyslipidemia, and particularly hypercholesterolemia, remains a main cardiovascular disease risk factor, partly reversible with the improvement of life-style, including dietary, habits. Even when a pharmacological treatment is begun, dietary support to lipid-lowering is always desired. This book will provide a selection of new evidence on the possible lipid-lowering effects of some dietary and medicinal plant components, reporting some interesting reviews, experimental data and results from clinical trials. The book is adapted for experts in nutrition but also for all scientists involved in cardiovascular disease prevention.

beta-glucan --- fiber --- lipid profile --- cholesterol --- intestinal function --- green tea --- epigallocatechin gallate --- chitosan --- microspheres --- Eudragit --- metabolic diseases --- LCD score --- CHNS --- dyslipidemia --- dietary factor --- plant based --- animal based --- Chinese adults --- nutraceuticals --- PCSK9 --- SREBP --- HNF1α --- berberine --- metabolic syndrome --- plant extracts --- natural antioxidant --- polyphenols --- bergamot --- blackcurrant --- liver steatosis --- ovariectomized --- phytoestrogen --- vitamin B12 --- healthy --- Saudi Arabia --- serum cholesterol --- serum triglycerides --- serum low density lipoprotein --- serum high density lipoprotein --- dietary intake --- lifestyle --- black raspberry --- excessive choline --- TMAO --- hypercholesterolemia --- hepatic inflammation --- review --- CVD --- cardiovascular health --- dietary fats --- dietary fiber --- phytosterols --- plant-based diet --- dietary pattern --- sustainability --- propolis --- formononetin --- gastric ulcer --- rats --- Chrysanthemum morifolium Ramat leaves --- obesity --- lipidomics --- liquid chromatography tandem mass spectrometry --- phospholipid --- sphingolipid --- monacolins --- LDL-cholesterol --- red yeast rice --- clinical trial --- endothelial function --- alpha-linolenic acid --- flaxseed --- lipids --- omega-3 --- walnuts --- type 2 diabetes mellitus --- glibenclamide --- omega-3 fatty acids --- high fat diet --- transcription factors --- streptozotocin --- Armolipid Plus® --- nutraceutical --- supplementation --- blood pressure --- fasting plasma glucose --- n/a

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Dyslipidemia, and particularly hypercholesterolemia, remains a main cardiovascular disease risk factor, partly reversible with the improvement of life-style, including dietary, habits. Even when a pharmacological treatment is begun, dietary support to lipid-lowering is always desired. This book will provide a selection of new evidence on the possible lipid-lowering effects of some dietary and medicinal plant components, reporting some interesting reviews, experimental data and results from clinical trials. The book is adapted for experts in nutrition but also for all scientists involved in cardiovascular disease prevention.

Public health & preventive medicine --- beta-glucan --- fiber --- lipid profile --- cholesterol --- intestinal function --- green tea --- epigallocatechin gallate --- chitosan --- microspheres --- Eudragit --- metabolic diseases --- LCD score --- CHNS --- dyslipidemia --- dietary factor --- plant based --- animal based --- Chinese adults --- nutraceuticals --- PCSK9 --- SREBP --- HNF1α --- berberine --- metabolic syndrome --- plant extracts --- natural antioxidant --- polyphenols --- bergamot --- blackcurrant --- liver steatosis --- ovariectomized --- phytoestrogen --- vitamin B12 --- healthy --- Saudi Arabia --- serum cholesterol --- serum triglycerides --- serum low density lipoprotein --- serum high density lipoprotein --- dietary intake --- lifestyle --- black raspberry --- excessive choline --- TMAO --- hypercholesterolemia --- hepatic inflammation --- review --- CVD --- cardiovascular health --- dietary fats --- dietary fiber --- phytosterols --- plant-based diet --- dietary pattern --- sustainability --- propolis --- formononetin --- gastric ulcer --- rats --- Chrysanthemum morifolium Ramat leaves --- obesity --- lipidomics --- liquid chromatography tandem mass spectrometry --- phospholipid --- sphingolipid --- monacolins --- LDL-cholesterol --- red yeast rice --- clinical trial --- endothelial function --- alpha-linolenic acid --- flaxseed --- lipids --- omega-3 --- walnuts --- type 2 diabetes mellitus --- glibenclamide --- omega-3 fatty acids --- high fat diet --- transcription factors --- streptozotocin --- Armolipid Plus® --- nutraceutical --- supplementation --- blood pressure --- fasting plasma glucose --- beta-glucan --- fiber --- lipid profile --- cholesterol --- intestinal function --- green tea --- epigallocatechin gallate --- chitosan --- microspheres --- Eudragit --- metabolic diseases --- LCD score --- CHNS --- dyslipidemia --- dietary factor --- plant based --- animal based --- Chinese adults --- nutraceuticals --- PCSK9 --- SREBP --- HNF1α --- berberine --- metabolic syndrome --- plant extracts --- natural antioxidant --- polyphenols --- bergamot --- blackcurrant --- liver steatosis --- ovariectomized --- phytoestrogen --- vitamin B12 --- healthy --- Saudi Arabia --- serum cholesterol --- serum triglycerides --- serum low density lipoprotein --- serum high density lipoprotein --- dietary intake --- lifestyle --- black raspberry --- excessive choline --- TMAO --- hypercholesterolemia --- hepatic inflammation --- review --- CVD --- cardiovascular health --- dietary fats --- dietary fiber --- phytosterols --- plant-based diet --- dietary pattern --- sustainability --- propolis --- formononetin --- gastric ulcer --- rats --- Chrysanthemum morifolium Ramat leaves --- obesity --- lipidomics --- liquid chromatography tandem mass spectrometry --- phospholipid --- sphingolipid --- monacolins --- LDL-cholesterol --- red yeast rice --- clinical trial --- endothelial function --- alpha-linolenic acid --- flaxseed --- lipids --- omega-3 --- walnuts --- type 2 diabetes mellitus --- glibenclamide --- omega-3 fatty acids --- high fat diet --- transcription factors --- streptozotocin --- Armolipid Plus® --- nutraceutical --- supplementation --- blood pressure --- fasting plasma glucose

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Alzheimer’s disease (AD) represents the most common form of dementia in the elderly population worldwide. AD is characterized by progressive neurodegeneration that leads to a gradual deterioration of memory and other cognitive functions. Given the global prevalence and impact of AD, there is a critical need to establish biomarkers that can be used to detect AD in individuals before the onset of clinical signs and provide mitigating therapeutics. The aim of this Special Issue is to discuss the current knowledge as well as future perspectives on the role of biomarkers in the screening, diagnosis, treatment and follow-up of AD.

flotillin --- Alzheimer’s disease --- biomarker --- exosomes --- beta-amyloid --- Tau --- aging --- biomarkers --- cytokines --- cognitive decline --- metabolomics --- neuroinflammation --- multivariate analysis --- physical performance --- person-tailored --- PET/CT --- (18F)FDG --- neuropsychological assessment --- APP mutations --- APOE alleles --- PSEN1 --- PSEN2 --- germline mutations --- late onset AD --- early onset AD --- familial AD --- genetics of AD --- mitochondrial spare respiratory capacity --- mitochondrial --- membrane potential --- glycolytic reserve --- semantic memory --- phonemic fluency --- episodic memory --- neuropsychology --- neuroimaging --- Alzheimer's disease --- mild cognitive impairment --- EEG --- TMS --- obesity --- diabetes --- inflammation --- Amyloid Beta --- mitochondrial dysfunction --- nutrition --- omega-3 fatty acids --- antioxidant --- carotenoids --- vitamin E --- cognition --- older adults --- ageing --- subjective cognitive decline --- clock genes --- Clock --- ApoE --- cardiovascular risk factors --- Alzheimer disease --- semantic priming --- amyloid beta --- cerebrospinal fluid --- amyloid beta peptide --- total tau --- phosphorylated tau --- diagnosis --- drug development --- clinical trials --- diagnostic research --- virus --- bacteria --- dementia --- blood --- behavioral and psychological symptoms of dementia (BPSD) --- Alzheimer’s disease (AD) --- neuropsychiatry inventory scale (NPI) --- endophenotypes --- CART analysis --- MTHFR --- APOE --- COMT --- genetic variants --- early diagnosis --- biofluids --- amyloid cascade hypothesis --- glucose metabolism --- adipose tissue dysfunction --- energetic metabolism --- lysosomes dysfunction --- Type-3-Diabetes --- neurodegeneration --- amyloid --- tau --- soluble TREM2 --- NfL --- Multiplex --- SiMoA --- diagnostics --- messenger RNA --- microRNA --- neurotropic microbes --- precision medicine --- prognostics --- synaptic biomarkers --- neurofilament light chain --- n/a --- Alzheimer's disease (AD)