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Affecting an estimated 2.5 million people worldwide, multiple sclerosis (MS) is the most common neurological cause of debilitation in young adults. Incurable, and with the precise causes still unknown, both diagnosis and management of the condition is complicated. This book summarizes the latest understanding of the causes of the disease, using accessible, bullet-point text to describe key clinical features and diagnostic criteria. Disease-modifying therapies and management of symptoms, including fatigue, tremor and cognitive changes, are covered in detail. With a chapter focusing solely on presentations in the emergency room, the importance of recognizing these neurological emergencies is emphasised, along with indications for admission in MS patients. The impact of MS on women's reproductive health and the increasing recognition of MS in pediatric patients is also explored. An up-to-date and practical approach to the accurate diagnosis and management of MS, this is an invaluable resource for both hospital and outpatient settings.

Multiple sclerosis. --- Multiple sclerosis --- Treatment.

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This book provides a clinical focus on neuroinflammatory diseases as well as a review in pathophysiology and treatment approaches. Organized into six parts, the book begins with a basic review of the immune system and concepts for learning and treating neuroimmune conditions. The next four sections cover specific subfields of neuroimmunology and autoimmune neurology - the clinical and diagnostic features of multiple sclerosis, other autoimmune conditions of the central nervous system, autoimmune conditions of the peripheral nervous system, and systemic autoimmune conditions that affect the nervous system. To conclude, Section six discusses various clinical approaches to specific presentations in neuroimmunology, including pediatric demyelinating diseases. These sections provide practical clinical information to improve the reader’s knowledge in this complex field. The chapters are written by world renown authors with extensive knowledge to help provide up to date information. The full scope of autoimmune neurology is discussed, which is a unique feature of this book. Neuroimmunology serves as a resource for those in training including residents and fellows to provide clear clinical reasoning and background in a rapidly advancing field.

Neurology . --- Immunology. --- Neurology. --- Immunobiology --- Life sciences --- Serology --- Medicine --- Nervous system --- Neuropsychiatry --- Diseases --- Multiple sclerosis --- Immunological aspects. --- MS (Disease) --- Sclerosis, Multiple --- Demyelination --- Myelin sheath --- Virus diseases --- Esclerosi múltiple --- Immunologia --- Biologia --- Complements (Immunitat) --- Immunofarmacologia --- Immunologia clínica --- Immunologia de la trasplantació --- Neuroimmunologia --- Resposta immunitària --- Sistema immunitari --- Esclerosi disseminada --- Esclerosi en plaques --- Malalties del sistema nerviós central --- Malalties immunitàries

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This book contains the latest findings in a number of research areas, including the effects of dog-assisted therapy on the psychomotor development of children with intellectual disability; the use of weighted blankets and sleep quality in children with autism spectrum disorders; cognitive assessment and rehabilitation for pediatric-onset multiple sclerosis; the use of gait indexes in detecting gait changes in children with spastic hemiplegic cerebral palsy; as well as the effect of ankle joint mobilization, functional progressive resistance exercise, and action observation training on range of motion, gait, spasticity, gross motor function, and balance in children with spastic cerebral palsy. The book is intended for people who work with children and adolescents with neurodysfunctions on a daily basis. It will certainly be useful to physiotherapists, medical doctors, psychologists, and all members of interdisciplinary therapeutic teams. The book can also be recommended to all individuals interested in neurorehabilitation, including parents or guardians of children and adolescents with neurodysfunctions.

cerebral palsy --- action observation --- spasticity --- gross motor function --- balance --- functional progressive resistance exercise --- muscle strength --- muscle tone --- ankle joint --- COP --- gait --- join mobilization --- gait analysis --- gait variablity index --- gait deviation index --- ankle–foot orthosis --- cognition --- cognitive rehabilitation --- pediatric multiple sclerosis --- weighted blankets --- sensory-based interventions --- autism spectrum disorder --- dog-assisted therapy --- intellectual disability --- psychomotor disorders --- child developmental --- kinesthesis --- cognition disorders --- dogs

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This book contains the latest findings in a number of research areas, including the effects of dog-assisted therapy on the psychomotor development of children with intellectual disability; the use of weighted blankets and sleep quality in children with autism spectrum disorders; cognitive assessment and rehabilitation for pediatric-onset multiple sclerosis; the use of gait indexes in detecting gait changes in children with spastic hemiplegic cerebral palsy; as well as the effect of ankle joint mobilization, functional progressive resistance exercise, and action observation training on range of motion, gait, spasticity, gross motor function, and balance in children with spastic cerebral palsy. The book is intended for people who work with children and adolescents with neurodysfunctions on a daily basis. It will certainly be useful to physiotherapists, medical doctors, psychologists, and all members of interdisciplinary therapeutic teams. The book can also be recommended to all individuals interested in neurorehabilitation, including parents or guardians of children and adolescents with neurodysfunctions.

Humanities --- Social interaction --- cerebral palsy --- action observation --- spasticity --- gross motor function --- balance --- functional progressive resistance exercise --- muscle strength --- muscle tone --- ankle joint --- COP --- gait --- join mobilization --- gait analysis --- gait variablity index --- gait deviation index --- ankle–foot orthosis --- cognition --- cognitive rehabilitation --- pediatric multiple sclerosis --- weighted blankets --- sensory-based interventions --- autism spectrum disorder --- dog-assisted therapy --- intellectual disability --- psychomotor disorders --- child developmental --- kinesthesis --- cognition disorders --- dogs --- cerebral palsy --- action observation --- spasticity --- gross motor function --- balance --- functional progressive resistance exercise --- muscle strength --- muscle tone --- ankle joint --- COP --- gait --- join mobilization --- gait analysis --- gait variablity index --- gait deviation index --- ankle–foot orthosis --- cognition --- cognitive rehabilitation --- pediatric multiple sclerosis --- weighted blankets --- sensory-based interventions --- autism spectrum disorder --- dog-assisted therapy --- intellectual disability --- psychomotor disorders --- child developmental --- kinesthesis --- cognition disorders --- dogs

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This book focuses on the design of polymeric delivery systems for biomedical and nanomedicine applications as well as on understanding how such biomaterials interact in the physiological environment. The reader will find an encompassing view on the state-of-the-art of polymeric carriers, showing how current research deals with new stimuli-responsive systems for cancer therapies and biomedical challenges, namely overcoming the skin barrier. The published papers cover topics ranging from novel production methods and insights on hybrid polymers to applications as diverse as nanoparticles, hydrogels and microneedles for antifungal skin therapy, peptide and siRNA delivery, enhanced skin absorption of bioactive molecules, and anticancer therapy. The book comprises one review paper and nine research papers.

Technology: general issues --- osteoarthritis --- monosodium iodoacetate --- p47phox --- PLGA nanoparticles --- reactive oxygen species --- full factorial design --- optimization --- metronidazole --- nanocomposites --- sodium alginate --- chitosan --- PLGA --- hybrid polymers --- chitosan-PLGA polymer --- NMR --- DSC --- FT-IR --- covalent drug conjugation --- therapeutic nanodevice --- polymeric nanoparticles --- cancer therapy --- controlled drug delivery --- redox responsive PEG-block-PLA --- nanocarriers --- disulfide bond --- controlled release --- retinol --- nanosponge --- hydrogel --- Box–Behnken design --- pharmacokinetic --- terbinafine hydrogel --- niacinamide --- polyethene glycol (PEG) 400 --- solvent --- dermal delivery --- finite dose --- porcine skin --- dissolving microneedles --- multiple sclerosis --- PLP --- transdermal delivery --- tyrosol --- nanoparticles --- Design of Experiment (DoE) --- β cyclodextrin --- DNA binding --- glyconanoparticles --- immunotherapy --- infectious diseases --- mannose receptors --- nutraceuticals --- n/a --- Box-Behnken design