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Over the last few decades, remarkable progress has been made in understanding the aetiology and pathophysiology of diseases and many new theories emphasize the importance of the small bowel ‘ecosystem’ in the pathogenesis of acute and chronic illness. Emerging factors such as microbiome, stem cells, innate intestinal immunity and the enteric nervous system along with mucosal and endothelial barriers have key role in the development of gastrointestinal and extra-intestinal diseases. Therefore, the small intestine is considered key player in metabolic disease development, including diabetes mellitus, and other diet-related disorders such as celiac and non-celiac enteropathies. Another major field is drug metabolism and its interaction with microbiota. Moreover, the emergence of gut-brain, gut-liver and gut-blood barriers points toward the important role of small intestine in the pathogenesis of common disorders, such as liver disease, hypertension and neurodegenerative disease. However, the small bowel remains an organ that is difficult to fully access and assess and accurate diagnosis often poses a clinical challenge. Eventually, the therapeutic potential remains untapped. Therefore, it is due time to direct our interest towards the small intestine and unravel the interplay between small-bowel and other gastrointestinal (GI) and non-GI related maladies.

Research & information: general --- Biology, life sciences --- capsule endoscopy --- Crohn’s disease --- mucosal healing --- small bowel --- gut brain axis --- microbiota --- functional gastrointestinal disorders --- inflammatory bowel disease (IBD) --- adult stem cells --- surgical site infections (SSIs) --- probiotics --- prebiotics --- synbiotics --- surgery --- adverse events --- meta-analysis --- systematic review --- hyperspectral imaging --- multispectral imaging --- clinical diagnosis --- biomedical optical imaging --- gastroenterology --- medical diagnostic imaging --- small-bowel mass --- small-bowel bulge --- video capsule endoscopy --- cystic fibrosis --- gut microbiota --- intestinal inflammation --- fecal calprotectin --- dysbiosis index --- celiac disease --- biomarker --- serology --- enteropathy --- n/a --- colon cancer --- cancer risk --- collagenous colitis --- lung cancer --- microscopic colitis --- skin cancer --- squamous cell carcinoma --- Crohn's disease

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This book uses new thinking on precision medicine and the interplay of genetic factors, the microbiome, and external triggers to build on the core concepts of inflammatory bowel disease. It outlines the latest findings in targeting therapies to the individual patient with Crohn’s and colitis, management of chronic infections in the setting of immunomodulators and biologics, non-surgical therapy of dysplasia in colitis patients, and redefining and structuring the problematic pouch. In addition, this book features useful chapters dedicated to the economic aspects of IBD in an increasingly constrained healthcare system, as well as the patient experience and the role of subspecialist telemedicine care. Written by specialists and thought leaders in the field, Inflammatory Bowel Disease: Pathogenesis, Diagnosis and Management provides a concise but highly relevant account of the latest thinking and concepts in IBD.

Inflammatory bowel diseases --- Pathogenesis. --- Diagnosis. --- IBD (Disease) --- Inflammatory bowel disease --- Intestines --- Gastroenteritis --- Inflammation --- Malalties intestinals --- Etiologia --- Diagnòstic --- Terapèutica --- Teràpia --- Tractament (Medicina) --- Tractament de les malalties --- Medicina clínica --- Al·lopatia (Terapèutica) --- Antipirètics --- Cateterisme --- Dietoteràpia --- Fisioteràpia --- Fórmules magistrals --- Hormonoteràpia --- Immunoteràpia --- Injeccions intraarticulars --- Intubació --- Ioga --- Logopèdia --- Medicina alternativa --- Nutrició --- Quimioteràpia --- Radiologia intervencionista --- Terapèutica dental --- Terapèutica fisiològica --- Teràpia genètica --- Teràpia intravenosa --- Teràpia respiratòria --- Terapèutica veterinària --- Tractament pal·liatiu --- Ús terapèutic --- Diagnosi --- Diagnòstic físic --- Examen mèdic (Diagnòstic) --- Exploració médica (Diagnòstic) --- Exploració clínica (Diagnòstic) --- Cribratge --- Diagnòstic d'infermeria --- Diagnòstic diferencial --- Diagnòstic dual --- Diagnòstic molecular --- Diagnòstic prenatal --- Diagnòstic quirúrgic --- Diagnòstic per la imatge --- Electrodiagnòstic --- Entrevista clínica --- Examen físic --- Isòtops radioactius en diagnòstic mèdic --- Monitoratge de pacients --- Proves funcionals (Medicina) --- Patologia --- Pronòstic mèdic --- Símptomes --- Causes de les malalties --- Diagnòstics etiològics --- Etiologia mèdica --- Patogènesi --- Accidents --- Infeccions --- Traumatisme --- Factors de risc en les malalties --- Enteropatia --- Enteropaties --- Malalties dels intestins --- Malalties de l'aparell digestiu --- Diarrea --- Disenteria --- Malalties de l'anus --- Malalties del còlon --- Malalties del recte --- Obstrucció intestinal --- Restrenyiment --- Internal medicine. --- Internal Medicine. --- Medicine, Internal --- Medicine