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Pharmacy. --- Bioinformatics. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology --- Data processing --- Farmacologia --- Bioinformàtica --- Informàtica biològica --- Ciències de la informació --- Biologia computacional --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Fotofarmacologia --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Toxicologia --- Medicaments --- Quimioteràpia

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Farmacologia --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Toxicologia --- Medicaments --- Quimioteràpia --- Wnt proteins. --- Neuropharmacology. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Nervous system --- Neurotropic drugs --- Neurosciences --- Pharmacology --- Glycoproteins --- Growth factors --- Physiological effect --- Effect of drugs on --- Fotofarmacologia

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Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Cardiology. --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Heart --- Internal medicine --- Diseases --- Oxigen actiu --- Ús terapèutic --- Farmacologia --- Pharmacology. --- Clinical biochemistry. --- Neuroscience. --- Medical Biochemistry. --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Fotofarmacologia --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Toxicologia --- Medicaments --- Quimioteràpia --- Aplicacions mèdiques --- Aplicacions terapèutiques --- Ús en medecina --- Medicina alternativa --- Terapèutica --- Anions superòxid --- Oxigen reactiu --- Radicals d'oxigen --- Oxigen --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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This open access book presents the history, pharmacokinetics and pharmacodynamics of levothyroxine, discussing its role in the thyroid pathophysiology of patients of various ages and during pregnancy. It also describes the influence of levothyroxine on heart, bone and in cancer. When it was first synthesized in 1949, levothyroxine represented a significant advance in the treatment of hypothyroidism, providing a safe and effective treatment option for millions of hypothyroid patients around the globe. This synthetic form of thyroxine is now one of the most prescribed drugs in the world. Levothyroxine was first introduced by Merck KGaA,Darmstadt, Germany, in 1972, and since then the company has remained actively engaged in research on this mainstay of hypothyroidism treatment. This book is intended for healthcare professionals.

Endocrinology . --- Pharmacology. --- Endocrinology. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Internal medicine --- Hormones --- Physiological effect --- Hormones tiroides --- Medicaments --- Farmacologia --- Malalties de les glàndules endocrines --- Tiroide --- Endocrinologia clínica --- Endocrinopaties --- Malalties endocrines --- Trastorns hormonals --- Diabetis --- Endocrinologia pediàtrica --- Ginecologia endocrina --- Hiperparatiroïdisme --- Hipoglucèmia --- Malalties de l'ovari --- Malalties de les glàndules suprarenals --- Malalties del testicle --- Pubertat precoç --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Toxicologia --- Quimioteràpia --- Fàrmacs --- Medicines --- Farmacopees --- Compostos bioactius --- Accés als medicaments --- Afrodisíacs --- Agents antilipèmics --- Antidiabètics --- Botànica mèdica --- Conservació de medicaments --- Contraceptius --- Diürètics --- Envasament de medicaments --- Excipients --- Farmacognòsia --- Interaccions dels medicaments --- Medicaments antineoplàstics --- Medicaments cardiovasculars --- Medicaments congelats --- Medicaments liofilitzats --- Medicaments orfes --- Medicaments peptídics --- Medicaments respiratoris --- Microbiologia farmacèutica --- Psicofàrmacs --- Prescripció de medicaments --- Preu dels medicaments --- Relaxants musculars --- Administració de medicaments --- Farmàcia --- Matèria mèdica --- Validació (Medicaments) --- Fotofarmacologia --- Endocrinology --- Pharmacology/Toxicology --- Pharmacology --- Thyroid gland --- Hypothyroidism --- TSH --- Thyroid disorders --- Metabolism --- Open Access

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Ocular pharmacology. --- Ophthalmic drugs. --- Eye --- Ophthalmopharmacology --- Pharmacology --- Ophthalmic drugs --- Materia medica, Ophthalmological --- Ophthalmic agents --- Drugs --- Therapeutics, Ophthalmological --- Ocular pharmacology --- Drug effects --- Effect of drugs on --- Farmacologia ocular --- Efecte dels medicaments sobre l'ull --- Efectes dels medicaments sobre l'ull --- Farmacologia oftalmològica --- Oftalmofarmacologia --- Farmacologia --- Col·liris