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Natural deep eutectic solvents (NADES) are pharmaceutically accepted systems not only because they typically offer a serious enhancement of active pharmaceutical ingredient (API) solubility, but also due to their non-toxicity. This fortunate conjuncture allows for designing new media for escalation and controlled release of APIs. For example, composition optimisation of a series of NADES comprising choline chloride with multi-hydroxyl compounds was successfully performed for a set of sulphonamide-based drugs. These results confirmed that NADES in general, and the ones based on choline chloride and glycerol particularly, are an attractive alternative to traditional solvents for sulphonamide dissolution. Experiments augmented with in silico modelling can offer deeper insights into the thermodynamic characteristics of these systems and an explanation for the origin of the observed solubility enhancement. Research of this type offers universal resolutions to the problem of low solubility issues for many types of drugs. Of particular interest is that such screening is not restricted to artificial in vitro environments but can be also easily adopted for the study of modelled in vivo situations. One of very important and interesting examples is a new curcumin–NADES formulation preserving its beneficial properties even after dilution with FaSSIF solution, which mimicks intestinal absorption.

Research & information: general --- deep eutectic solvents --- molecularly imprinted polymers --- extraction --- phenolic compounds --- antioxidant activity --- spruce bark --- phytomass --- valorization --- deep eutectic solvent --- composite resins --- hydrogen bond --- eutectic solvents --- natural deep eutectic solvents --- nanostructured ionic solvents --- neoteric solvents --- ionic liquids --- ionic liquid --- hybrid solvent --- CO2 solubility --- Henry’s constant --- viscosity

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In the oral environment, restorative and prosthetic materials and appliances are exposed to chemical, thermal and mechanical challenges. The mechanical properties of a material define how it responds to the application of a physical force. Recent advances in nanotechnology and 3D printing have rapidly spread, and manufacturers continuously develop new materials and solutions to provide high-quality dental care, with particular attention being paid to long-term follow-up. Restorative dentistry, prosthodontics, oral surgery, implants, periodontology and orthodontics are all involved in this continuing evolution. This Special Issue focuses on all the recent technology that can enhance the mechanical properties of materials used in all of the different branches of dentistry.

Technology: general issues --- zirconia --- digital dentistry --- lithium disilicate --- resin bonded bridge --- fracture --- adhesive restorations --- CAD/CAM --- PMMA --- surface roughness --- microhybrid composite --- sandblasting --- surface treatment --- composite repair --- minimal invasive dentistry --- concrete --- fracture properties --- dry environments --- different curing temperatures --- temperature crossover effect --- dental materials --- orthodontics --- obstructive sleep apnea --- mandibular advancement device --- finite element method --- composite resins --- compressive strength --- fixed partial denture --- AZ31 magnesium alloy --- nanoindentation --- indentation size effect --- anisotropic yielding criterion --- temperature rise --- composites --- polymerization --- flexural strength --- zirconia --- digital dentistry --- lithium disilicate --- resin bonded bridge --- fracture --- adhesive restorations --- CAD/CAM --- PMMA --- surface roughness --- microhybrid composite --- sandblasting --- surface treatment --- composite repair --- minimal invasive dentistry --- concrete --- fracture properties --- dry environments --- different curing temperatures --- temperature crossover effect --- dental materials --- orthodontics --- obstructive sleep apnea --- mandibular advancement device --- finite element method --- composite resins --- compressive strength --- fixed partial denture --- AZ31 magnesium alloy --- nanoindentation --- indentation size effect --- anisotropic yielding criterion --- temperature rise --- composites --- polymerization --- flexural strength

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In the oral environment, restorative and prosthetic materials and appliances are exposed to chemical, thermal and mechanical challenges. The mechanical properties of a material define how it responds to the application of a physical force. Recent advances in nanotechnology and 3D printing have rapidly spread, and manufacturers continuously develop new materials and solutions to provide high-quality dental care, with particular attention being paid to long-term follow-up. Restorative dentistry, prosthodontics, oral surgery, implants, periodontology and orthodontics are all involved in this continuing evolution. This Special Issue focuses on all the recent technology that can enhance the mechanical properties of materials used in all of the different branches of dentistry.

zirconia --- digital dentistry --- lithium disilicate --- resin bonded bridge --- fracture --- adhesive restorations --- CAD/CAM --- PMMA --- surface roughness --- microhybrid composite --- sandblasting --- surface treatment --- composite repair --- minimal invasive dentistry --- concrete --- fracture properties --- dry environments --- different curing temperatures --- temperature crossover effect --- dental materials --- orthodontics --- obstructive sleep apnea --- mandibular advancement device --- finite element method --- composite resins --- compressive strength --- fixed partial denture --- AZ31 magnesium alloy --- nanoindentation --- indentation size effect --- anisotropic yielding criterion --- temperature rise --- composites --- polymerization --- flexural strength

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The interaction of bacteria with biomaterials’ surfaces has critical clinical implications on the development and progression of biofilm-related diseases. In this book "Bacterial Interactions with Dental and Medical Materials", encouraging findings on tissue-contacting biomaterials to control biofilms, enhanced understanding of key mechanisms, and clinical perspectives are discussed toward improving healthcare.

Research & information: general --- polymer --- dental --- antibacterial --- antifouling --- hydroxyapatite --- star-shaped --- hydrophobicity --- acrylic acid --- oral --- composition --- antimicrobial effect --- biofilms --- cytotoxicity --- dental resins --- physicochemical properties --- mechanical properties --- quaternary ammonium methacrylates --- dental materials --- dentistry --- adhesives --- light-curing of dental adhesives --- composite resins --- methylmethacrylate --- oxides --- cerium --- polymers --- dentine bonding agents --- anti-bacterial agents --- dental caries --- biocompatible materials --- quaternary ammonium compounds --- antimicrobial --- ceramic --- coating --- silicon carbide --- fluoride(s) --- biofilm(s) --- Streptococcus mutans --- bioreactor(s) --- enamel --- composite materials --- biomaterials --- nanostructured materials --- chronic wounds --- infection --- chick embryo CAM --- ex ovo --- bioactive desensitizer --- hypersensitivity --- SEM --- nanoparticle --- nanohydroxyapatite --- microshear bond strength --- phosphoric acid --- self-etch --- porous bioceramics --- wollastonite --- sol-gel technology --- spark plasma sintering-reactive synthesis --- bacterial test --- surface modification --- coatings --- implant --- biofilm --- silver --- copper --- polylysine --- dental composites --- protein repellent --- restorations --- zwitterionic polymers --- dental composite --- antibiofilm --- dental nanocomposite --- calcium fluoride nanoparticles --- remineralization --- oral biofilm --- electrospinning --- nano-hydroxyapatite --- toxicity --- bone regeneration --- white spot lesions --- orthodontic --- polymer --- dental --- antibacterial --- antifouling --- hydroxyapatite --- star-shaped --- hydrophobicity --- acrylic acid --- oral --- composition --- antimicrobial effect --- biofilms --- cytotoxicity --- dental resins --- physicochemical properties --- mechanical properties --- quaternary ammonium methacrylates --- dental materials --- dentistry --- adhesives --- light-curing of dental adhesives --- composite resins --- methylmethacrylate --- oxides --- cerium --- polymers --- dentine bonding agents --- anti-bacterial agents --- dental caries --- biocompatible materials --- quaternary ammonium compounds --- antimicrobial --- ceramic --- coating --- silicon carbide --- fluoride(s) --- biofilm(s) --- Streptococcus mutans --- bioreactor(s) --- enamel --- composite materials --- biomaterials --- nanostructured materials --- chronic wounds --- infection --- chick embryo CAM --- ex ovo --- bioactive desensitizer --- hypersensitivity --- SEM --- nanoparticle --- nanohydroxyapatite --- microshear bond strength --- phosphoric acid --- self-etch --- porous bioceramics --- wollastonite --- sol-gel technology --- spark plasma sintering-reactive synthesis --- bacterial test --- surface modification --- coatings --- implant --- biofilm --- silver --- copper --- polylysine --- dental composites --- protein repellent --- restorations --- zwitterionic polymers --- dental composite --- antibiofilm --- dental nanocomposite --- calcium fluoride nanoparticles --- remineralization --- oral biofilm --- electrospinning --- nano-hydroxyapatite --- toxicity --- bone regeneration --- white spot lesions --- orthodontic