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Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease.
Health --- Chronobiology --- Circadian rhythms --- Redox --- Metabolism --- Mathematical modeling
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Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease.
Health & Fitness / Sleep --- Health --- Chronobiology --- Circadian rhythms --- Redox --- Metabolism --- Mathematical modeling
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Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease.
Health & Fitness / Sleep --- Health --- Chronobiology --- Circadian rhythms --- Redox --- Metabolism --- Mathematical modeling
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Sleep-wake cycle --- Research --- Methodology. --- Cycle, Sleep-wake --- Patterns, Sleep --- Sleep cycle --- Sleep patterns --- Wake-sleep cycle --- Circadian rhythms
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Prokaryotes. --- Circadian rhythms. --- Behavior, Circadian --- Biological clocks, Daily --- Circadian behavior --- Circadian clocks --- Circadian cycles --- Clocks, Circadian --- Cycles, Circadian --- Daily activity cycles --- Daily biological clocks --- Diel cycles --- Diurnal rhythms --- Rhythms, Circadian --- Biological rhythms --- Monera --- Procaryotae --- Procaryotes --- Prokaryonta --- Prokaryotae --- Prokaryotic protists --- Microorganisms --- Procariotes --- Ritmes circadiaris
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Psychology --- Neuropathology --- neurologie --- neuropsychologie --- Circadian rhythms. --- Brain --- Diseases. --- Brain diseases --- Psychology, Pathological --- Behavior, Circadian --- Biological clocks, Daily --- Circadian behavior --- Circadian clocks --- Circadian cycles --- Clocks, Circadian --- Cycles, Circadian --- Daily activity cycles --- Daily biological clocks --- Diel cycles --- Diurnal rhythms --- Rhythms, Circadian --- Biological rhythms
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Circadian rhythms. --- Brain --- Diseases. --- Brain diseases --- Psychology, Pathological --- Behavior, Circadian --- Biological clocks, Daily --- Circadian behavior --- Circadian clocks --- Circadian cycles --- Clocks, Circadian --- Cycles, Circadian --- Daily activity cycles --- Daily biological clocks --- Diel cycles --- Diurnal rhythms --- Rhythms, Circadian --- Biological rhythms --- Ritmes circadiaris --- Salut mental --- Malalties cerebrals --- Encefalopaties --- Malalties del cervell --- Trastorns cerebrals --- Malalties del sistema nerviós central --- Afàsia --- Demència --- Edema cerebral --- Encefalitis --- Encefalopatia hepàtica --- Esclerosi tuberosa --- Epilèpsia --- Lesions cerebrals --- Malaltia de Parkinson --- Malalties cerebrovasculars --- Síndrome de Lesch-Nyhan --- Tumors cerebrals --- Psicopatologia --- Síndrome de Rett --- Higiene mental --- Salut emocional --- Psiquiatria --- Salut pública --- Estrès (Psicologia) --- Psiquiatria social --- Realització personal --- Assistència psiquiàtrica --- Equipaments de salut mental --- Malalties mentals --- Treball social en salut mental --- Cicles d'activitat diària --- Rellotges biològics diaris --- Bioritmes
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This Special Issue addresses a topic of great contemporary relevance; in developed countries, most of peoples’ time is spent indoors and, depending on each person, the presence in the home ranges from 60% to 90% of the day, and 30% of that time is spent sleeping. Taking into account these data, indoor residential environments have a direct influence on human health. In addition to this, in developing countries, significant levels of indoor pollution make housing unsafe, with a detrimental impact on the health of inhabitants. Housing is therefore a key health factor for people all over the world, and various parameters such as air quality, ventilation, hygrothermal comfort, lighting, physical environment, and building efficiency, among others, can contribute to healthy architecture, and the conditions that can result from the poor application of these parameters.
Technology: general issues --- vernacular architecture --- sustainability --- energy efficiency --- history --- statistics --- society --- acoustics --- environmental quality --- learning space --- occupant comfort --- sustainable architecture --- sustainable building --- visual comfort --- thermal comfort --- ventilation comfort --- VOCs --- polymer-based items --- indoor air quality --- test emission chamber --- exposure scenario --- natural lighting --- artificial lighting --- indoor lighting design --- chronodisruption --- circadian rhythms --- daylighting --- sustainable lighting design --- LED luminaires --- indoor environment quality --- classroom lighting --- sustainable development --- desalination --- reverse osmosis --- renewable energies --- environmental impacts --- decision support systems --- types of contract --- in-vehicle air quality --- pollution model --- thermal environment --- solar radiation --- VOCs exposure --- CFD --- environmental health --- building energy simulation --- water flow glazing --- experimental validation --- schools --- heat perception --- user’s perception --- qualitative technique --- POE --- weather file management --- weather datasets --- weather stations --- sensitivity analysis of weather parameters --- thermal zone temperature --- building energy management --- unitized facade --- Water Flow Glazing --- mean radiant temperature --- final energy consumption --- Artificial Neural Network (ANN) --- Global Data Assimilation System (GDAS) --- Numerical Weather Prediction (NWP) --- photovoltaic power --- weather data --- facility management --- construction materials --- “smelly buildings” --- Belgrade --- Serbia --- Mexico --- energy simulation --- building energy model --- Open Studio --- SGSAVE --- NOM-020-ENER-2011 --- climate zoning --- traditional construction systems --- social housing --- verification method --- climate change --- global warming --- carbon footprint --- GHG emissions --- climate emergency --- hydrogen --- PEM fuel cells --- cogeneration --- building sustainability --- energy saving --- hygrothermal comfort --- indoor green --- vertical greenery --- cost-benefit-ratio --- sick leave --- absenteeism --- alternative quantification method
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This Special Issue addresses a topic of great contemporary relevance; in developed countries, most of peoples’ time is spent indoors and, depending on each person, the presence in the home ranges from 60% to 90% of the day, and 30% of that time is spent sleeping. Taking into account these data, indoor residential environments have a direct influence on human health. In addition to this, in developing countries, significant levels of indoor pollution make housing unsafe, with a detrimental impact on the health of inhabitants. Housing is therefore a key health factor for people all over the world, and various parameters such as air quality, ventilation, hygrothermal comfort, lighting, physical environment, and building efficiency, among others, can contribute to healthy architecture, and the conditions that can result from the poor application of these parameters.
vernacular architecture --- sustainability --- energy efficiency --- history --- statistics --- society --- acoustics --- environmental quality --- learning space --- occupant comfort --- sustainable architecture --- sustainable building --- visual comfort --- thermal comfort --- ventilation comfort --- VOCs --- polymer-based items --- indoor air quality --- test emission chamber --- exposure scenario --- natural lighting --- artificial lighting --- indoor lighting design --- chronodisruption --- circadian rhythms --- daylighting --- sustainable lighting design --- LED luminaires --- indoor environment quality --- classroom lighting --- sustainable development --- desalination --- reverse osmosis --- renewable energies --- environmental impacts --- decision support systems --- types of contract --- in-vehicle air quality --- pollution model --- thermal environment --- solar radiation --- VOCs exposure --- CFD --- environmental health --- building energy simulation --- water flow glazing --- experimental validation --- schools --- heat perception --- user’s perception --- qualitative technique --- POE --- weather file management --- weather datasets --- weather stations --- sensitivity analysis of weather parameters --- thermal zone temperature --- building energy management --- unitized facade --- Water Flow Glazing --- mean radiant temperature --- final energy consumption --- Artificial Neural Network (ANN) --- Global Data Assimilation System (GDAS) --- Numerical Weather Prediction (NWP) --- photovoltaic power --- weather data --- facility management --- construction materials --- “smelly buildings” --- Belgrade --- Serbia --- Mexico --- energy simulation --- building energy model --- Open Studio --- SGSAVE --- NOM-020-ENER-2011 --- climate zoning --- traditional construction systems --- social housing --- verification method --- climate change --- global warming --- carbon footprint --- GHG emissions --- climate emergency --- hydrogen --- PEM fuel cells --- cogeneration --- building sustainability --- energy saving --- hygrothermal comfort --- indoor green --- vertical greenery --- cost-benefit-ratio --- sick leave --- absenteeism --- alternative quantification method
Choose an application
This Special Issue addresses a topic of great contemporary relevance; in developed countries, most of peoples’ time is spent indoors and, depending on each person, the presence in the home ranges from 60% to 90% of the day, and 30% of that time is spent sleeping. Taking into account these data, indoor residential environments have a direct influence on human health. In addition to this, in developing countries, significant levels of indoor pollution make housing unsafe, with a detrimental impact on the health of inhabitants. Housing is therefore a key health factor for people all over the world, and various parameters such as air quality, ventilation, hygrothermal comfort, lighting, physical environment, and building efficiency, among others, can contribute to healthy architecture, and the conditions that can result from the poor application of these parameters.
Technology: general issues --- vernacular architecture --- sustainability --- energy efficiency --- history --- statistics --- society --- acoustics --- environmental quality --- learning space --- occupant comfort --- sustainable architecture --- sustainable building --- visual comfort --- thermal comfort --- ventilation comfort --- VOCs --- polymer-based items --- indoor air quality --- test emission chamber --- exposure scenario --- natural lighting --- artificial lighting --- indoor lighting design --- chronodisruption --- circadian rhythms --- daylighting --- sustainable lighting design --- LED luminaires --- indoor environment quality --- classroom lighting --- sustainable development --- desalination --- reverse osmosis --- renewable energies --- environmental impacts --- decision support systems --- types of contract --- in-vehicle air quality --- pollution model --- thermal environment --- solar radiation --- VOCs exposure --- CFD --- environmental health --- building energy simulation --- water flow glazing --- experimental validation --- schools --- heat perception --- user’s perception --- qualitative technique --- POE --- weather file management --- weather datasets --- weather stations --- sensitivity analysis of weather parameters --- thermal zone temperature --- building energy management --- unitized facade --- Water Flow Glazing --- mean radiant temperature --- final energy consumption --- Artificial Neural Network (ANN) --- Global Data Assimilation System (GDAS) --- Numerical Weather Prediction (NWP) --- photovoltaic power --- weather data --- facility management --- construction materials --- “smelly buildings” --- Belgrade --- Serbia --- Mexico --- energy simulation --- building energy model --- Open Studio --- SGSAVE --- NOM-020-ENER-2011 --- climate zoning --- traditional construction systems --- social housing --- verification method --- climate change --- global warming --- carbon footprint --- GHG emissions --- climate emergency --- hydrogen --- PEM fuel cells --- cogeneration --- building sustainability --- energy saving --- hygrothermal comfort --- indoor green --- vertical greenery --- cost-benefit-ratio --- sick leave --- absenteeism --- alternative quantification method
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