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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- mitral regurgitation --- trans-catheter mitral valve repair --- heart failure --- structural heart intervention --- mitral --- mitral regurgitation --- trans-catheter mitral valve repair --- heart failure --- structural heart intervention --- mitral

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

mitral regurgitation --- trans-catheter mitral valve repair --- heart failure --- structural heart intervention --- mitral

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The present special issue will lead you to discover the association between cerebrovascular events, cognitive impairment and atrial fibrillation, through update reviews and original articles exploring the pathophysiological mechanisms underpinning this association and describing the latest results in term of stroke prevention in AF. An interesting scientific journey that reflects the recent advances in pharmacological treatments and interventional procedures involving both mind and heart.

memory loss --- antioxidant --- neuroprotective --- acetylcholinesterase inhibitor --- molecular docking --- atrial --- fibrillation --- venous --- thrombosis --- anticoagulation --- perception --- chronic obstructive pulmonary disease --- atrial fibrillation --- cardiovascular risk --- outcome --- prognosis --- novel oral anticoagulants --- prosthetic valve replacement --- subclinical atrial fibrillation --- stroke --- ischemic cerebral events --- catheter ablation --- screening --- cognitive impairment --- atrial fibrillation ablation --- iatrogenic interatrial septum defect --- paradoxical embolism --- anticoagulant interruption --- cardioversion --- oral anticoagulation therapy --- left atrial appendage thrombosis --- transesophageal echocardiography --- IL1B --- IL1RN --- polymorphism --- inflammation --- cognitive decline --- rhythm control --- microbleeds --- cerebral ischemia --- diabetes mellitus --- metformin --- thiazolidinediones --- GLP-1 receptor agonists --- SGLT-2 inhibitors --- atrial high rate episodes --- NOACs --- non vitamin K oral anticoagulants --- oral anticoagulation --- intracerebral hemorrhage --- cerebral small vessel disease --- brain MRI --- circulating biomarkers --- direct oral anticoagulants (DOACs) --- atrial fibrillation (AF) --- electrical cardioversion (EC) --- surgical cryoablation --- left atrial function --- minimally invasive mitral valve repair --- echocardiography --- aneurysmal subarachnoid hemorrhage --- interdisciplinary setting --- metabolic syndrome --- obesity --- dementia --- n/a

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Advanced experimental and computational biomechanics have become essential components to better understand the physiological and pathological conditions of biological tissues in the human body. Recent advances in medical imaging modalities, image segmentation, tissue characterization experiments, and predictive computer simulations have made major contributions to transforming current therapeutic paradigms, towards the facilitation of patient-specific diagnostics and individualized surgery planning. This Special Issue of Bioengineering on Advances in Biological Tissue Biomechanics, therefore, focuses on research dealing with cutting-edge experimental and computational methodologies for biomechanical investigations of tissues in the human body system across multiple spatial and temporal scales.

Research & information: general --- Biology, life sciences --- computational fluid dynamics --- bileaflet mechanical heart valve --- adverse hemodynamics --- transvalvular pressure gradients --- turbulent shear stresses --- blood damage --- platelet activation --- aortic valve --- calcification --- elastin degradation --- leaflet --- curvature --- biomarker --- early detection --- porcine brain --- mechanical behavior --- hydration effects --- Split-Hopkinson pressure bar --- micromechanics --- finite element analysis --- collagen crimp --- elastin --- microstructures --- force-controlled mechanical testing --- the tricuspid valve --- functional tricuspid regurgitation --- cardiovascular imaging --- mechanical characterization --- in-vitro experiments --- constitutive modeling --- geometrical modeling --- finite element modeling --- isogeometric analysis (IGA) --- biaxial mechanical characterization --- fluid-structure interactions --- material anisotropy --- sub-valvular components --- soft tissue --- liver --- high-rate compression --- polymeric split-Hopkinson pressure bar --- pentagalloyl glucose --- aneurysm --- enzyme --- biomechanics --- aorta --- biaxial mechanical testing --- cardiac valves --- osmotic swelling --- parameter estimation --- nonlinear preconditioning --- gradient-based minimization --- cirrus --- myocardium --- stiffness --- viscoelastic property --- anisotropy --- fibrosis --- the mitral valve --- collagen fiber architecture --- glycosaminoglycan --- uniaxial mechanical testing --- in-vitro flow loops --- polarized spatial frequency domain imaging --- tricuspid regurgitation --- spatial alignment --- collagen fiber reorientation --- in vivo stress/strain quantification --- constitutive models --- soft tissues --- growth and remodeling (G & R) --- multiscale biomechanics --- patient-specific modeling --- computational fluid dynamics --- bileaflet mechanical heart valve --- adverse hemodynamics --- transvalvular pressure gradients --- turbulent shear stresses --- blood damage --- platelet activation --- aortic valve --- calcification --- elastin degradation --- leaflet --- curvature --- biomarker --- early detection --- porcine brain --- mechanical behavior --- hydration effects --- Split-Hopkinson pressure bar --- micromechanics --- finite element analysis --- collagen crimp --- elastin --- microstructures --- force-controlled mechanical testing --- the tricuspid valve --- functional tricuspid regurgitation --- cardiovascular imaging --- mechanical characterization --- in-vitro experiments --- constitutive modeling --- geometrical modeling --- finite element modeling --- isogeometric analysis (IGA) --- biaxial mechanical characterization --- fluid-structure interactions --- material anisotropy --- sub-valvular components --- soft tissue --- liver --- high-rate compression --- polymeric split-Hopkinson pressure bar --- pentagalloyl glucose --- aneurysm --- enzyme --- biomechanics --- aorta --- biaxial mechanical testing --- cardiac valves --- osmotic swelling --- parameter estimation --- nonlinear preconditioning --- gradient-based minimization --- cirrus --- myocardium --- stiffness --- viscoelastic property --- anisotropy --- fibrosis --- the mitral valve --- collagen fiber architecture --- glycosaminoglycan --- uniaxial mechanical testing --- in-vitro flow loops --- polarized spatial frequency domain imaging --- tricuspid regurgitation --- spatial alignment --- collagen fiber reorientation --- in vivo stress/strain quantification --- constitutive models --- soft tissues --- growth and remodeling (G & R) --- multiscale biomechanics --- patient-specific modeling

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• Reference Manager
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Advanced experimental and computational biomechanics have become essential components to better understand the physiological and pathological conditions of biological tissues in the human body. Recent advances in medical imaging modalities, image segmentation, tissue characterization experiments, and predictive computer simulations have made major contributions to transforming current therapeutic paradigms, towards the facilitation of patient-specific diagnostics and individualized surgery planning. This Special Issue of Bioengineering on Advances in Biological Tissue Biomechanics, therefore, focuses on research dealing with cutting-edge experimental and computational methodologies for biomechanical investigations of tissues in the human body system across multiple spatial and temporal scales.

computational fluid dynamics --- bileaflet mechanical heart valve --- adverse hemodynamics --- transvalvular pressure gradients --- turbulent shear stresses --- blood damage --- platelet activation --- aortic valve --- calcification --- elastin degradation --- leaflet --- curvature --- biomarker --- early detection --- porcine brain --- mechanical behavior --- hydration effects --- Split-Hopkinson pressure bar --- micromechanics --- finite element analysis --- collagen crimp --- elastin --- microstructures --- force-controlled mechanical testing --- the tricuspid valve --- functional tricuspid regurgitation --- cardiovascular imaging --- mechanical characterization --- in-vitro experiments --- constitutive modeling --- geometrical modeling --- finite element modeling --- isogeometric analysis (IGA) --- biaxial mechanical characterization --- fluid-structure interactions --- material anisotropy --- sub-valvular components --- soft tissue --- liver --- high-rate compression --- polymeric split-Hopkinson pressure bar --- pentagalloyl glucose --- aneurysm --- enzyme --- biomechanics --- aorta --- biaxial mechanical testing --- cardiac valves --- osmotic swelling --- parameter estimation --- nonlinear preconditioning --- gradient-based minimization --- cirrus --- myocardium --- stiffness --- viscoelastic property --- anisotropy --- fibrosis --- the mitral valve --- collagen fiber architecture --- glycosaminoglycan --- uniaxial mechanical testing --- in-vitro flow loops --- polarized spatial frequency domain imaging --- tricuspid regurgitation --- spatial alignment --- collagen fiber reorientation --- in vivo stress/strain quantification --- constitutive models --- soft tissues --- growth and remodeling (G & R) --- multiscale biomechanics --- patient-specific modeling