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Regeneration (Biology) --- Biomedical engineering --- Wound healing --- Biomedical materials. --- Tissue scaffolds. --- Tissue Engineering --- Regenerative Medicine --- Biomedical Engineering --- Régénération (Biologie) --- Génie biomédical --- Cicatrisation --- Biomatériaux. --- Structures d'échafaudage tissulaires. --- methods --- Régénération (Biologie) --- Génie biomédical --- Biomatériaux. --- Structures d'échafaudage tissulaires.

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Electrospinning is a versatile and effective technique widely used to manufacture nanofibrous structures from a diversity of materials (synthetic, natural or inorganic). The electrospun nanofibrous meshes’ composition, morphology, porosity, and surface functionality support the development of advanced solutions for many biomedical applications. The Special Issue on “Electrospun Nanofibers for Biomedical Applications” assembles a set of original and highly-innovative contributions showcasing advanced devices and therapies based on or involving electrospun meshes. It comprises 13 original research papers covering topics that span from biomaterial scaffolds’ structure and functionalization, nanocomposites, antibacterial nanofibrous systems, wound dressings, monitoring devices, electrical stimulation, bone tissue engineering to first-in-human clinical trials. This publication also includes four review papers focused on drug delivery and tissue engineering applications.

History of engineering & technology --- sol-gel --- electrospinning --- hydroxyapatite --- nanofiber --- antibacterial --- titanium --- antibacterial coatings --- nanocomposite coatings --- TiO2 photocatalytic --- orthopedic infections --- 3D printing --- nanofibers --- encapsulation --- protein diffusion --- in vivo tissue engineering --- immuno-isolation --- transplantation --- sputtering --- drug delivery --- wound dressing --- biocompatibility --- tissue engineering --- biomimetic scaffolds --- gelatin --- micromolding --- biomaterials --- poly(lactic acid) (PLLA) --- bioactive glass --- scaffolds --- composite fibres --- bone regeneration --- poly(vinylidene fluoride) --- composite nanofiber --- piezoelectricity --- antioxidant activity --- well-aligned nanofibers --- P(VDF-TrFE) --- piezoelectric nanogenerator --- preosteoblasts electrospinning --- silicone modified polyurethane nanofibers --- physical properties --- cell attachment --- cell proliferation --- cytotoxicity --- biopolymers --- packaging --- pharmaceutical --- biomedical --- alginate --- gelatin fibers --- ZnO particles --- antibacterial activity --- fabrication --- therapeutics --- biomedical applications --- antibody immobilization --- electrospun nanofibers --- TNF-α capture --- human articular chondrocytes --- rheumatoid arthritis --- microfluidic chip --- live assay --- hepatocellular carcinoma cells --- PLA95 --- guided tissue regeneration (GTR) --- electrospun fiber mats --- mechanobiology --- glioblastoma --- finite element modeling --- cancer treatment --- drug release --- nanomedicine --- biocompatible polymers --- hyperthermia

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The sustainable exploitation of marine biodiversity is one structural column of the “blue economy”, and the discovery of new compounds and materials to be used in biomedicine is considered one of the most strategic activities, within an economic context. An exhaustive selection of the different typologies of approaches used by marine biotechnologists to develop research on these topics are demonstrated in the eight original articles and two reviews comprising this Special Issue. The reported scientific publications describe the discovery of new compounds for cancer therapy or for the control of bacterial virulence. Different new uses of marine chitin or chitosan-based materials are also shown for the first time, as well as novel green techniques for the extraction of compounds from marine algae or from fishery waste, which are described in the two reviews.

Extracellular Polymeric Substances --- hydrogel --- mesenchymal stem cells --- biomaterials --- enzyme --- omega 3 --- PUFA --- Trichormus variabilis --- Cyanobacteria --- mechanochemical synthesis --- chitosan --- laser stereolithography --- long-term stability --- scaffold --- tissue reaction --- chitin --- scaffolds --- biological materials --- demosponges --- Pseudoceratina arabica --- microalgae --- biodiversity --- bioactive compounds --- green extractions --- pharmaceutical --- secondary metabolites --- biofuels --- antibiofilm --- fucoidan --- motility --- nanoparticles --- Pseudomonas aeruginosa --- virulence factors --- n-3 fatty acids --- brain --- α-Chitin --- prodigiosin --- anti-tumors --- Serratia marcescens --- bioprocessing --- echinochrome A --- estradiol --- extracellular matrix --- vocal fold --- ovariectomy --- marine polymers --- ionic liquids --- tissue engineering --- membranes --- hydrogels --- sponges --- Chondrosin --- Chondrosia reniformis --- marine toxin --- cytotoxic protein --- Porifera --- marine --- microbes --- cancer --- prevention --- therapy --- in vitro --- in vivo --- clinical studies

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The sustainable exploitation of marine biodiversity is one structural column of the “blue economy”, and the discovery of new compounds and materials to be used in biomedicine is considered one of the most strategic activities, within an economic context. An exhaustive selection of the different typologies of approaches used by marine biotechnologists to develop research on these topics are demonstrated in the eight original articles and two reviews comprising this Special Issue. The reported scientific publications describe the discovery of new compounds for cancer therapy or for the control of bacterial virulence. Different new uses of marine chitin or chitosan-based materials are also shown for the first time, as well as novel green techniques for the extraction of compounds from marine algae or from fishery waste, which are described in the two reviews.

Technology: general issues --- Extracellular Polymeric Substances --- hydrogel --- mesenchymal stem cells --- biomaterials --- enzyme --- omega 3 --- PUFA --- Trichormus variabilis --- Cyanobacteria --- mechanochemical synthesis --- chitosan --- laser stereolithography --- long-term stability --- scaffold --- tissue reaction --- chitin --- scaffolds --- biological materials --- demosponges --- Pseudoceratina arabica --- microalgae --- biodiversity --- bioactive compounds --- green extractions --- pharmaceutical --- secondary metabolites --- biofuels --- antibiofilm --- fucoidan --- motility --- nanoparticles --- Pseudomonas aeruginosa --- virulence factors --- n-3 fatty acids --- brain --- α-Chitin --- prodigiosin --- anti-tumors --- Serratia marcescens --- bioprocessing --- echinochrome A --- estradiol --- extracellular matrix --- vocal fold --- ovariectomy --- marine polymers --- ionic liquids --- tissue engineering --- membranes --- hydrogels --- sponges --- Chondrosin --- Chondrosia reniformis --- marine toxin --- cytotoxic protein --- Porifera --- marine --- microbes --- cancer --- prevention --- therapy --- in vitro --- in vivo --- clinical studies

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Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.

Technology: general issues --- polyurethane --- injectable hydrogels --- ion/drug delivery --- mesoporous bioactive glasses --- tissue regeneration --- mesoporous silica --- therapeutic biomolecules --- proteins --- peptides --- nucleic acids --- glycans --- nanoporous silicon --- gold nanoparticles --- drug delivery --- cancer cells --- theranostics --- mesoporous silica nanoparticles --- core-shell --- surface functionalization --- cell targeting --- size-dependent delivery --- antitumoral microRNA (miRNA) --- confocal microscopy --- tumor targeting --- stimuli responsive --- multimodal decorations --- targeted and controlled cargo release --- cancer therapy and diagnosis --- alginate–poloxamer copolymer --- silk fibroin --- dual network hydrogel --- mesoporous bioactive glass --- insulin-like growth factor-1 --- electrostatic gating --- nanofluidic diffusion --- controlled drug release --- silicon membrane --- smart drug delivery --- three-dimensional porous scaffolds --- electron beam melting --- selective laser sintering --- stereolithography --- electrospinning --- two-photon polymerization --- osteogenesis --- antibiotics --- anti-inflammatory --- n/a --- alginate-poloxamer copolymer