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Cardiovascular Diseases --- Integrative Medicine --- Patient-Specific Modeling --- Precision Medicine --- methods --- methods

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Hygiene. Public health. Protection --- Semiology. Diagnosis. Symptomatology --- Information systems --- Artificial intelligence. Robotics. Simulation. Graphics --- Artificial intelligence --- Precision Medicine --- Artificial Intelligence --- Medical applications. --- Computational Intelligence --- AI (Artificial Intelligence) --- Computer Reasoning --- Computer Vision Systems --- Knowledge Acquisition (Computer) --- Knowledge Representation (Computer) --- Machine Intelligence --- Acquisition, Knowledge (Computer) --- Computer Vision System --- Intelligence, Artificial --- Intelligence, Computational --- Intelligence, Machine --- Knowledge Representations (Computer) --- Reasoning, Computer --- Representation, Knowledge (Computer) --- System, Computer Vision --- Systems, Computer Vision --- Vision System, Computer --- Vision Systems, Computer --- Heuristics --- P Health --- P-Health --- Personalized Medicine --- Theranostics --- Individualized Medicine --- Predictive Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- Medicine, Predictive --- Theranostic --- Pharmacogenomic Variants --- Pharmacogenetics --- Patient-Specific Modeling --- Medicine --- Data processing

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Advanced experimental and computational biomechanics have become essential components to better understand the physiological and pathological conditions of biological tissues in the human body. Recent advances in medical imaging modalities, image segmentation, tissue characterization experiments, and predictive computer simulations have made major contributions to transforming current therapeutic paradigms, towards the facilitation of patient-specific diagnostics and individualized surgery planning. This Special Issue of Bioengineering on Advances in Biological Tissue Biomechanics, therefore, focuses on research dealing with cutting-edge experimental and computational methodologies for biomechanical investigations of tissues in the human body system across multiple spatial and temporal scales.

Research & information: general --- Biology, life sciences --- computational fluid dynamics --- bileaflet mechanical heart valve --- adverse hemodynamics --- transvalvular pressure gradients --- turbulent shear stresses --- blood damage --- platelet activation --- aortic valve --- calcification --- elastin degradation --- leaflet --- curvature --- biomarker --- early detection --- porcine brain --- mechanical behavior --- hydration effects --- Split-Hopkinson pressure bar --- micromechanics --- finite element analysis --- collagen crimp --- elastin --- microstructures --- force-controlled mechanical testing --- the tricuspid valve --- functional tricuspid regurgitation --- cardiovascular imaging --- mechanical characterization --- in-vitro experiments --- constitutive modeling --- geometrical modeling --- finite element modeling --- isogeometric analysis (IGA) --- biaxial mechanical characterization --- fluid-structure interactions --- material anisotropy --- sub-valvular components --- soft tissue --- liver --- high-rate compression --- polymeric split-Hopkinson pressure bar --- pentagalloyl glucose --- aneurysm --- enzyme --- biomechanics --- aorta --- biaxial mechanical testing --- cardiac valves --- osmotic swelling --- parameter estimation --- nonlinear preconditioning --- gradient-based minimization --- cirrus --- myocardium --- stiffness --- viscoelastic property --- anisotropy --- fibrosis --- the mitral valve --- collagen fiber architecture --- glycosaminoglycan --- uniaxial mechanical testing --- in-vitro flow loops --- polarized spatial frequency domain imaging --- tricuspid regurgitation --- spatial alignment --- collagen fiber reorientation --- in vivo stress/strain quantification --- constitutive models --- soft tissues --- growth and remodeling (G & R) --- multiscale biomechanics --- patient-specific modeling --- computational fluid dynamics --- bileaflet mechanical heart valve --- adverse hemodynamics --- transvalvular pressure gradients --- turbulent shear stresses --- blood damage --- platelet activation --- aortic valve --- calcification --- elastin degradation --- leaflet --- curvature --- biomarker --- early detection --- porcine brain --- mechanical behavior --- hydration effects --- Split-Hopkinson pressure bar --- micromechanics --- finite element analysis --- collagen crimp --- elastin --- microstructures --- force-controlled mechanical testing --- the tricuspid valve --- functional tricuspid regurgitation --- cardiovascular imaging --- mechanical characterization --- in-vitro experiments --- constitutive modeling --- geometrical modeling --- finite element modeling --- isogeometric analysis (IGA) --- biaxial mechanical characterization --- fluid-structure interactions --- material anisotropy --- sub-valvular components --- soft tissue --- liver --- high-rate compression --- polymeric split-Hopkinson pressure bar --- pentagalloyl glucose --- aneurysm --- enzyme --- biomechanics --- aorta --- biaxial mechanical testing --- cardiac valves --- osmotic swelling --- parameter estimation --- nonlinear preconditioning --- gradient-based minimization --- cirrus --- myocardium --- stiffness --- viscoelastic property --- anisotropy --- fibrosis --- the mitral valve --- collagen fiber architecture --- glycosaminoglycan --- uniaxial mechanical testing --- in-vitro flow loops --- polarized spatial frequency domain imaging --- tricuspid regurgitation --- spatial alignment --- collagen fiber reorientation --- in vivo stress/strain quantification --- constitutive models --- soft tissues --- growth and remodeling (G & R) --- multiscale biomechanics --- patient-specific modeling

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This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Cancer research. --- Oncology  . --- Human genetics. --- Bioinformatics. --- Nanotechnology. --- Cancer Research. --- Oncology. --- Human Genetics. --- Nanotechnology and Microengineering. --- Molecular technology --- Nanoscale technology --- High technology --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Tumors --- Cancer research --- Data processing --- Cancer --- Genetic aspects. --- Precision Medicine. --- Neoplasms --- genetics. --- Cancer genetics --- Cancer genes --- P Health --- P-Health --- Personalized Medicine --- Individualized Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- P-Healths --- Pharmacogenomic Variants --- Pharmacogenetics --- Patient-Specific Modeling --- Theranostics --- Predictive Medicine --- Medicine, Predictive --- Theranostic --- Genètica humana --- Càncer --- Oncologia --- Bioinformàtica --- Nanotecnologia --- Informàtica biològica --- Ciències de la informació --- Biologia computacional --- Medicina --- Oncologia geriàtrica --- Oncologia pediàtrica --- Oncologia veterinària --- Infermeria oncològica --- Carcinoma --- Carcinosi --- Càncer d'ossos --- Càncer de cap --- Càncer de coll --- Càncer de bufeta --- Càncer de fetge --- Càncer de laringe --- Càncer de mama --- Càncer de pàncrees --- Càncer de pell --- Càncer de pròstata --- Càncer de pulmó --- Càncer de ronyó --- Càncer de tiroide --- Càncer d'ovari --- Càncer gastrointestinal --- Càncer ginecològic --- Càncer en els adolescents --- Càncer en els infants --- Medicaments antineoplàstics --- Melanoma --- Leucèmia --- Sarcoma --- Carcinògens --- Cèl·lules canceroses --- Cirurgia oncològica --- Malalts de càncer --- Metàstasi --- Enginyeria molecular --- Tecnologia molecular --- Alta tecnologia --- Electrònica molecular --- Espintrònica --- Materials nanoestructurats --- Nanoelectrònica --- Nanolitografia --- Nanomedicina --- Nanoquímica --- Antropologia física --- Biologia humana --- Genètica --- Herència humana --- Citogenètica humana --- Cromosomes humans --- Genètica de poblacions humanes --- Genètica mèdica --- Genètica molecular humana --- Psicologia genètica --- Genoma humà

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Advanced experimental and computational biomechanics have become essential components to better understand the physiological and pathological conditions of biological tissues in the human body. Recent advances in medical imaging modalities, image segmentation, tissue characterization experiments, and predictive computer simulations have made major contributions to transforming current therapeutic paradigms, towards the facilitation of patient-specific diagnostics and individualized surgery planning. This Special Issue of Bioengineering on Advances in Biological Tissue Biomechanics, therefore, focuses on research dealing with cutting-edge experimental and computational methodologies for biomechanical investigations of tissues in the human body system across multiple spatial and temporal scales.

computational fluid dynamics --- bileaflet mechanical heart valve --- adverse hemodynamics --- transvalvular pressure gradients --- turbulent shear stresses --- blood damage --- platelet activation --- aortic valve --- calcification --- elastin degradation --- leaflet --- curvature --- biomarker --- early detection --- porcine brain --- mechanical behavior --- hydration effects --- Split-Hopkinson pressure bar --- micromechanics --- finite element analysis --- collagen crimp --- elastin --- microstructures --- force-controlled mechanical testing --- the tricuspid valve --- functional tricuspid regurgitation --- cardiovascular imaging --- mechanical characterization --- in-vitro experiments --- constitutive modeling --- geometrical modeling --- finite element modeling --- isogeometric analysis (IGA) --- biaxial mechanical characterization --- fluid-structure interactions --- material anisotropy --- sub-valvular components --- soft tissue --- liver --- high-rate compression --- polymeric split-Hopkinson pressure bar --- pentagalloyl glucose --- aneurysm --- enzyme --- biomechanics --- aorta --- biaxial mechanical testing --- cardiac valves --- osmotic swelling --- parameter estimation --- nonlinear preconditioning --- gradient-based minimization --- cirrus --- myocardium --- stiffness --- viscoelastic property --- anisotropy --- fibrosis --- the mitral valve --- collagen fiber architecture --- glycosaminoglycan --- uniaxial mechanical testing --- in-vitro flow loops --- polarized spatial frequency domain imaging --- tricuspid regurgitation --- spatial alignment --- collagen fiber reorientation --- in vivo stress/strain quantification --- constitutive models --- soft tissues --- growth and remodeling (G & R) --- multiscale biomechanics --- patient-specific modeling