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This book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics. Starting with a basic introduction to protein purification, estimation, storage, and its effect on the protein structure, function, and dynamics, it also discusses various experimental and computational structure determination approaches; the importance of molecular interactions and water in protein stability, folding and dynamics; kinetic and thermodynamic parameters associated with protein-ligand binding; single molecule techniques and their applications in studying protein folding and aggregation; protein quality control; the role of amino acid sequence in protein aggregation; muscarinic acetylcholine receptors, antimuscarinic drugs, and their clinical significances. Further, the book explains the current understanding on the therapeutic importance of the enzyme dopamine beta hydroxylase; structural dynamics and motions in molecular motors; role of cathepsins in controlling degradation of extracellular matrix during disease states; and the important structure-function relationship of iron-binding proteins, ferritins. Overall, the book is an important guide and a comprehensive resource for understanding protein structure, function, dynamics, and interaction.

Proteins . --- Enzymology. --- Medical genetics. --- Bioinformatics. --- Protein Science. --- Protein Structure. --- Gene Function. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Biochemistry --- Enzymes --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Data processing --- Genetic aspects --- Protein Conformation. --- Protein Folding. --- Proteins. --- Enzymes. --- Biocatalysts --- Molecular Mechanisms of Pharmacological Action --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Proteostasis --- Protein Multimerization --- Intrinsically Disordered Proteins --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Proteins --- Protein Folding --- (Produktform)Electronic book text. --- Proteïnes --- Bioinformàtica --- Informàtica biològica --- Ciències de la informació --- Biologia computacional --- Biomolècules --- Albúmines --- Apoproteïnes --- Conformació de proteïnes --- Enzims --- Factors de transcripció --- Glicoproteïnes --- Lipoproteïnes --- Nucleoproteïnes --- Pèptids --- Prions --- Protamines --- Proteïnes citosquelètiques --- Proteïnes de membrana --- Proteïnes de la sang --- Proteïnes recombinants --- Proteïnes supressores de tumors --- Receptors cel·lulars --- Ubiqüitina --- Xaperones moleculars --- Proteòmica

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This book summarizes the efforts of ten papers collected by the Special Issue "Condensed-Matter-Principia Based Information & Statistical Measures: From Classical to Quantum". It calls for papers which deal with condensed-matter systems, or their interdisciplinary analogs, for which well-defined classical–statistical vs. quantum information measures can be inferred while based on the entropy concept. The contents have mainly been rested upon objectives addressed by an international colloquium held on October 2019, in UTP Bydgoszcz, Poland (see http://zmpf.imif.utp.edu.pl/rci-jcs/rci-jcs-4/), with an emphasis placed on the achievements of Professor Gerard Czajkowski, who commenced his research activity with open diffusion–reaction systems under the supervision of Roman S. Ingarden (Toruń), a father of Polish synergetics, and original thermodynamic approaches to self-organization. The active cooperation of Professor Czajkowski, mainly with German physicists (Friedrich Schloegl, Aachen; Werner Ebeling, Berlin), ought to be highlighted. In light of this, a development of his research, as it has moved from statistical thermodynamics to solid state theory, pursued in terms of nonlinear solid-state optics (Franco Bassani, Pisa), and culminated very recently with large quasiparticles termed Rydberg excitons, and their coherent interactions with light, is worth delineating.

entropy --- second law --- thermodynamics --- Shannon measure of information --- information theory --- surface plasmons --- fractals --- quantum plasmonics --- beyond dipole --- entanglement --- electromagnetically induced transparency --- cross-Kerr nonlinearity --- Gazeau–Klauder coherent states --- Helstrom bound --- chemical computing --- oscillatory reaction --- genetic optimization --- classification problem --- interacting oscillators --- Flory–De Gennes exponent --- conformation of protein --- albumin --- non-gaussian chain --- non-isothermal characteristics --- Fisher’s test --- Kullback–Leibler divergence --- network --- flow --- channel --- probability distribution --- Shannon information measure --- cross-entropy --- drones --- swarms --- robustness --- information --- classical vs. quantum system --- condensed matter --- soft matter --- complex systems

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This eBook focuses on current progress in understanding the role of chromatin structure, its modifications and remodeling in developmental and physiological processes. Eukaryotic genomes are packed into the supramolecular nucleoprotein structure of chromatin. Therefore, our understanding of processes such as DNA replication and repair, transcription, and cell differentiation requires an understanding of the structure and function of chromatin. While the nucleotide sequence of the DNA component of chromatin constitutes the genetic material of the cell, the other chromatin components (and also modifications of bases in the DNA itself) participate in so-called epigenetic processes. These processes are essential, e.g., in ontogenesis or adaptation to environmental changes. Therefore, epigenetics is particularly important (and elaborated) in plants that show a high developmental plasticity and, as sessile organisms, display an enormous capacity to cope with environmental stress. In these processes, epigenetic mechanisms show a crosstalk with plant signaling pathways mediated by phytohormones and redox components. You are welcome to read examples of current research and review articles in this hot research topic.

Research & information: general --- Biology, life sciences --- auxin --- chromatin remodeling factor --- cuticular wax --- drought tolerance --- epigenetic regulation --- leaf width --- histone modification --- narrow leaf --- OsCHR4 --- rice --- 3D-FISH --- barley --- chromatin --- hybrid --- introgression --- nucleus --- rye --- wheat --- chromatin remodeling --- INO80/SWR1 complexes --- NuA4 complex --- histone variant H2A.Z --- gene regulation --- plant development --- Arabidopsis thaliana --- epigenetics --- histone --- mass spectrometry --- post-translational modifications --- sodium butyrate --- trichostatin A --- Swi3-like proteins --- gene expression --- protein interaction --- leaf development --- tomato --- Arabidopsis --- KNL2 --- kinetochores --- RNA-seq --- centromere --- SWI3C --- SWI/SNF --- cold response --- ATP-dependent chromatin remodeling --- transcriptional control of gene expression --- circRNAs --- jasmonic acid --- GO enrichment --- miRNA decoys --- epigenetic modifications --- DNA methylation --- redox regulation --- reactive oxygen species --- nitric oxide --- antioxidants --- circular chromosome conformation capture --- genome architecture --- T-DNA --- transgenic --- chromosomal rearrangements --- synthetic biology --- auxin --- chromatin remodeling factor --- cuticular wax --- drought tolerance --- epigenetic regulation --- leaf width --- histone modification --- narrow leaf --- OsCHR4 --- rice --- 3D-FISH --- barley --- chromatin --- hybrid --- introgression --- nucleus --- rye --- wheat --- chromatin remodeling --- INO80/SWR1 complexes --- NuA4 complex --- histone variant H2A.Z --- gene regulation --- plant development --- Arabidopsis thaliana --- epigenetics --- histone --- mass spectrometry --- post-translational modifications --- sodium butyrate --- trichostatin A --- Swi3-like proteins --- gene expression --- protein interaction --- leaf development --- tomato --- Arabidopsis --- KNL2 --- kinetochores --- RNA-seq --- centromere --- SWI3C --- SWI/SNF --- cold response --- ATP-dependent chromatin remodeling --- transcriptional control of gene expression --- circRNAs --- jasmonic acid --- GO enrichment --- miRNA decoys --- epigenetic modifications --- DNA methylation --- redox regulation --- reactive oxygen species --- nitric oxide --- antioxidants --- circular chromosome conformation capture --- genome architecture --- T-DNA --- transgenic --- chromosomal rearrangements --- synthetic biology

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This eBook focuses on current progress in understanding the role of chromatin structure, its modifications and remodeling in developmental and physiological processes. Eukaryotic genomes are packed into the supramolecular nucleoprotein structure of chromatin. Therefore, our understanding of processes such as DNA replication and repair, transcription, and cell differentiation requires an understanding of the structure and function of chromatin. While the nucleotide sequence of the DNA component of chromatin constitutes the genetic material of the cell, the other chromatin components (and also modifications of bases in the DNA itself) participate in so-called epigenetic processes. These processes are essential, e.g., in ontogenesis or adaptation to environmental changes. Therefore, epigenetics is particularly important (and elaborated) in plants that show a high developmental plasticity and, as sessile organisms, display an enormous capacity to cope with environmental stress. In these processes, epigenetic mechanisms show a crosstalk with plant signaling pathways mediated by phytohormones and redox components. You are welcome to read examples of current research and review articles in this hot research topic.

auxin --- chromatin remodeling factor --- cuticular wax --- drought tolerance --- epigenetic regulation --- leaf width --- histone modification --- narrow leaf --- OsCHR4 --- rice --- 3D-FISH --- barley --- chromatin --- hybrid --- introgression --- nucleus --- rye --- wheat --- chromatin remodeling --- INO80/SWR1 complexes --- NuA4 complex --- histone variant H2A.Z --- gene regulation --- plant development --- Arabidopsis thaliana --- epigenetics --- histone --- mass spectrometry --- post-translational modifications --- sodium butyrate --- trichostatin A --- Swi3-like proteins --- gene expression --- protein interaction --- leaf development --- tomato --- Arabidopsis --- KNL2 --- kinetochores --- RNA-seq --- centromere --- SWI3C --- SWI/SNF --- cold response --- ATP-dependent chromatin remodeling --- transcriptional control of gene expression --- circRNAs --- jasmonic acid --- GO enrichment --- miRNA decoys --- epigenetic modifications --- DNA methylation --- redox regulation --- reactive oxygen species --- nitric oxide --- antioxidants --- circular chromosome conformation capture --- genome architecture --- T-DNA --- transgenic --- chromosomal rearrangements --- synthetic biology --- n/a

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The search for bioactive marine natural products calls for the need of efficient chemical profiling strategies, together with the need to make advances in separation and characterization methodologies, in order to expedite their discovery. This Special Issue of Marine Drugs aims to highlight advances in extraction, isolation, purification and dereplication methodologies in the quest for bioactive marine natural products.

Research & information: general --- Chaceon quinquedens --- cold water species --- red deep-sea crab --- insulin-like androgenic gland hormone (IAG) --- androgenic gland --- bioguided-discovery --- dereplication --- cytotoxicity --- antifungal --- MS/HRMS --- marine-derived --- pimarane-type diterpenoids --- ilicicolin H --- trichothecene mycotoxins --- roridin --- verrucarin --- high-speed countercurrent chromatography --- preparative separation --- stepwise elution --- Eustigmatos cf. polyphem --- violaxanthin --- culture conditions --- purification --- antioxidant activity --- Mosher --- retroflexanone --- phloroglucinol --- HPLC-NMR --- secondary alcohol --- cephalimysins --- Aspergillus fumigatus --- marine microorganism --- Mugil cephalus --- spiro-heterocyclic γ-lactam --- circular dichroism spectroscopy --- hydroxypropyltrimethyl ammonium chloride chitosan --- halogenated acetate --- antifungal activity --- electronegativity --- microalgae --- Haematococcus pluvialis --- astaxanthin --- lutein --- fatty acids --- supercritical fluid extraction --- natural medicines --- chondroitin sulfate production --- cartilage Galeus melastomus by-products --- sulfation patterns --- process optimization --- molecular weight glycosaminoglycans determination --- bycatch waste management --- electronic circular dichroism --- absolute configuration --- molecular conformation --- electric transition dipole moment --- exciton coupling --- TDDFT calculations --- Chaceon quinquedens --- cold water species --- red deep-sea crab --- insulin-like androgenic gland hormone (IAG) --- androgenic gland --- bioguided-discovery --- dereplication --- cytotoxicity --- antifungal --- MS/HRMS --- marine-derived --- pimarane-type diterpenoids --- ilicicolin H --- trichothecene mycotoxins --- roridin --- verrucarin --- high-speed countercurrent chromatography --- preparative separation --- stepwise elution --- Eustigmatos cf. polyphem --- violaxanthin --- culture conditions --- purification --- antioxidant activity --- Mosher --- retroflexanone --- phloroglucinol --- HPLC-NMR --- secondary alcohol --- cephalimysins --- Aspergillus fumigatus --- marine microorganism --- Mugil cephalus --- spiro-heterocyclic γ-lactam --- circular dichroism spectroscopy --- hydroxypropyltrimethyl ammonium chloride chitosan --- halogenated acetate --- antifungal activity --- electronegativity --- microalgae --- Haematococcus pluvialis --- astaxanthin --- lutein --- fatty acids --- supercritical fluid extraction --- natural medicines --- chondroitin sulfate production --- cartilage Galeus melastomus by-products --- sulfation patterns --- process optimization --- molecular weight glycosaminoglycans determination --- bycatch waste management --- electronic circular dichroism --- absolute configuration --- molecular conformation --- electric transition dipole moment --- exciton coupling --- TDDFT calculations