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book (4)


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2020 (4)

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Book
Toxicological Effects of Mycotoxins on Target Cells
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Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Mycotoxins are a Public Health concern that in last year have reached the top 10 food and product hazard categories in the Rapid Alert System for Food and Feed (RASFF), with almost six hundred notifications. The toxicological effects of mycotoxins are evaluated through the extrapolation of results from in vivo and in vitro assays. Studies of mycotoxins’ effects at the cellular level precede those in organs and systems. All these studies are key steps for risk assessment and following legislation for mycotoxins. This Special Issue of Toxins comprises 10 original contributions and two reviews. The Issue reports new findings regarding toxic mechanisms, the use of innovative techniques to study the potential toxicity of mycotoxins not only individually but in combination, reflecting a real scenario according to current studies of mycotoxins.


Book
Toxicological Effects of Mycotoxins on Target Cells
Author:
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Mycotoxins are a Public Health concern that in last year have reached the top 10 food and product hazard categories in the Rapid Alert System for Food and Feed (RASFF), with almost six hundred notifications. The toxicological effects of mycotoxins are evaluated through the extrapolation of results from in vivo and in vitro assays. Studies of mycotoxins’ effects at the cellular level precede those in organs and systems. All these studies are key steps for risk assessment and following legislation for mycotoxins. This Special Issue of Toxins comprises 10 original contributions and two reviews. The Issue reports new findings regarding toxic mechanisms, the use of innovative techniques to study the potential toxicity of mycotoxins not only individually but in combination, reflecting a real scenario according to current studies of mycotoxins.


Book
Toxicological Effects of Mycotoxins on Target Cells
Author:
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

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Bookmark

Abstract

Mycotoxins are a Public Health concern that in last year have reached the top 10 food and product hazard categories in the Rapid Alert System for Food and Feed (RASFF), with almost six hundred notifications. The toxicological effects of mycotoxins are evaluated through the extrapolation of results from in vivo and in vitro assays. Studies of mycotoxins’ effects at the cellular level precede those in organs and systems. All these studies are key steps for risk assessment and following legislation for mycotoxins. This Special Issue of Toxins comprises 10 original contributions and two reviews. The Issue reports new findings regarding toxic mechanisms, the use of innovative techniques to study the potential toxicity of mycotoxins not only individually but in combination, reflecting a real scenario according to current studies of mycotoxins.

Keywords

Medicine. --- Destruxin A --- Bombyx mori --- binding protein --- BmTudor-sn --- Bm12 cell --- Ochratoxin A (OTA) --- human Stem Cells --- mycotoxins --- cells --- cytotoxicity --- cell culture --- T-2 toxin --- HT-2 toxin --- apoptosis --- autophagy --- endophyte --- fungi --- neurotoxin --- lolitrems --- ochratoxin A --- beauvericin --- mixtures --- HepG2 cells --- genotoxicity --- cell cycle --- Fusarium --- Aspergillus --- Penicillium --- Alternaria --- emerging mycotoxin --- in vitro --- IPEC-J2 --- occurrence data --- trichothecene --- biosynthetic pathway --- acetyltransferase --- deacetylase --- deoxynivalenol --- 3-acetyldeoxynivalenol --- isotrichodermol --- isotrichodermin --- differentiated Caco-2 cells --- cell apoptosis --- transcriptome analysis --- hepatocyte --- chicken --- acute toxicity --- combined toxicity --- cell protection --- silibinin --- in silico prediction --- co-culture models --- mycotoxin interaction --- Loewe additivity --- combination index --- isobologram --- Chou-Talalay method --- MixLow --- IPEC-J2 cells --- RNA-seq --- inflammation --- MAPKs --- Destruxin A --- Bombyx mori --- binding protein --- BmTudor-sn --- Bm12 cell --- Ochratoxin A (OTA) --- human Stem Cells --- mycotoxins --- cells --- cytotoxicity --- cell culture --- T-2 toxin --- HT-2 toxin --- apoptosis --- autophagy --- endophyte --- fungi --- neurotoxin --- lolitrems --- ochratoxin A --- beauvericin --- mixtures --- HepG2 cells --- genotoxicity --- cell cycle --- Fusarium --- Aspergillus --- Penicillium --- Alternaria --- emerging mycotoxin --- in vitro --- IPEC-J2 --- occurrence data --- trichothecene --- biosynthetic pathway --- acetyltransferase --- deacetylase --- deoxynivalenol --- 3-acetyldeoxynivalenol --- isotrichodermol --- isotrichodermin --- differentiated Caco-2 cells --- cell apoptosis --- transcriptome analysis --- hepatocyte --- chicken --- acute toxicity --- combined toxicity --- cell protection --- silibinin --- in silico prediction --- co-culture models --- mycotoxin interaction --- Loewe additivity --- combination index --- isobologram --- Chou-Talalay method --- MixLow --- IPEC-J2 cells --- RNA-seq --- inflammation --- MAPKs


Book
New Insights into Parvovirus Research
Author:
ISBN: 3039283111 3039283103 Year: 2020 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Viruses in the Parvoviridae family constitute one of the most diverse and intriguing fields of research. While they all share an ssDNA genome and a small capsid, they can differ widely in structure, genome organization and expression, virus–cell interaction, and impact on the host. Exploring such diversity and unraveling the inherent complexity in these apparently simple viruses is an ongoing endeavor and commitment for the scientific community. The translational implications of research on parvoviruses are relevant. Within the family, some viruses are important human and veterinary pathogens, in need of diagnostic methods and antiviral strategies; other viruses have long been studied and engineered as tools for oncolytic therapy, or as sophisticated gene delivery vectors, and can now display their wide and expanding applicative potential. This Special Issue of Viruses collects recent contributions in the field of parvovirus research, with a focus on new insights and research on unresolved issues, as well as new approaches exploiting systemic methodologies. Evolution, structural biology, viral replication, virus–host interaction, pathogenesis and immunity, and viral oncotherapy are a selection of the topics addressed in the issue that can be of relevance to the community involved in parvovirus research and of interest to a wider audience.

Keywords

antivirals --- Bombyx mori bidensovirus --- Bocaparvovirus --- human bocavirus 1 --- equine parvovirus-hepatitis --- NS2 --- NS1 --- X-ray crystallography --- BIRC3 (cIAP-2) --- glycans --- children --- antibody interactions --- new viruses --- alpaca --- cidofovir --- rodent protoparvoviruses --- clinical trials --- structural biology --- DNA virus --- human bocavirus --- caspase-3 --- viral communities --- uncoating --- PLA2 --- phospholipase-A2 --- oncolytic virus immune therapy --- Parvoviridae --- viral ecology --- Cryo-EM --- AAV --- metagenomics --- phylogeny --- oncolytic viruses --- mite --- parvovirus evolution --- Carnivore protoparvovirus 1 --- adeno-associated virus --- telbivudine --- capsid stability --- virus --- homology modeling --- human airway epithelia --- sequence analysis --- acute gastroenteritis --- bisulfite PCR --- next-generation sequencing --- single stranded DNA virus --- overlapping promoters --- virus diversity --- prognosis --- oncolytic activity --- genome --- hydroxyurea --- Lepidoptera --- genome externalization --- antiviral compounds --- circulating angiogenic cells --- tumor microenvironment --- coumarin derivatives --- nuclear targeting --- densovirus --- receptor interactions --- cell cycle arrest --- transcription profile --- brincidofovir --- canine parvovirus --- endogenous viral elements --- inflammatory cardiomyopathy --- erythroid progenitor cells --- RNA-seq --- insect --- chapparvovirus --- RT-qPCR --- trafficking --- AAV2 --- agricultural pests --- Adeno-associated virus --- myocarditis --- diagnosis --- parvovirus --- feline panleukopenia virus --- chitin --- B19V --- transcription mapping --- flavonoids --- immunomodulation --- erythrovirus --- apoptosis --- adenoviral vector --- anti-cancer --- divalent cations --- protease --- genetics --- preclinical --- arthropod --- peritrophins --- biocontrol --- dilated cardiomyopathy --- insect parvovirus --- combination therapies --- intravenous immunoglobulin (IVIG) --- virus phylogeny --- evolution --- second generation parvovirus treatments --- commercial horse serum --- parvovirus B19 --- canine chapparvovirus --- CpG methylation --- RACE --- H-1PV --- viral metagenomics --- horses

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