Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The purpose of this book is to provide a broad scope of substance use disorder research and how these findings can impact treatment outcomes. The research and outcomes described in this book represent important principles related to identifying and understanding factors related to substance use disorders. The first section is dedicated to methodology including population-based surveys, basic neuroanatomy, chemistry, molecular biology, behavioral models and brain imaging. The second section utilizes this methodology in research related to opioids, cocaine, marijuana, alcohol and nicotine. The book is aimed at both professionals (academics, clinicians, practitioners) and students or trainees.

Substance abuse --- Etiology. --- Pharmacology. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Malalties mentals --- Farmacologia --- Drogues --- Dopatge en els esports --- Drogoaddicció --- Drogues de disseny --- Drogues i escoles --- Heroïna --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Toxicologia --- Medicaments --- Quimioteràpia --- Bogeria --- Malaltia mental --- Psicopatia --- Discapacitat física --- Psicopatologia --- Psiquiatria --- Deficiència mental --- Geni i malalties mentals --- Salut mental --- Fotofarmacologia --- Malalties mentals.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This is the second edition of a well-received book in the series “Drug Discovery and Evaluation” The completely revised new edition of the volume reflects the current state of the art in Clinical Pharmacology. Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology". For the 2nd edition of this volume, the chapters have been revised and completely updated. A large number of assays were added. New chapters were included, such as pain, addiction, gene therapy, orphan diseases.

Pharmacology. --- Medical biochemistry. --- Pharmacotherapy. --- Pharmacology/Toxicology. --- Medical Biochemistry. --- Drug therapy --- Pharmacotherapy --- Therapeutics --- Drugs --- Pharmacology --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Pharmacy --- Physiological effect --- Drug development. --- Development of drugs --- New drug development --- Development --- Farmacologia --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Toxicologia --- Medicaments --- Quimioteràpia --- Fotofarmacologia --- Clinical biochemistry. --- Chemotherapy. --- Farmacologia.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.

Pharmacology. --- Systems biology. --- Oncology  . --- Medicine—Philosophy. --- Pharmacology/Toxicology. --- Systems Biology. --- Oncology. --- Philosophy of Medicine. --- Tumors --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Drug development. --- Development of drugs --- New drug development --- Pharmacology --- Development --- Farmacologia --- Ciències de la salut --- Biomedicina --- Ciències biomèdiques --- Ciències mèdiques --- Ciències de la vida --- Fisiologia humana --- Microbiologia mèdica --- Neurociències --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Toxicologia --- Medicaments --- Quimioteràpia --- Fotofarmacologia

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers, etc. The most important aspect of the book covers various types of nanoformulations and their applications in the treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, cancer, arthritis and tuberculosis.

Pharmacology. --- Pharmacotherapy. --- Pharmacology/Toxicology. --- Drug therapy --- Pharmacotherapy --- Therapeutics --- Drugs --- Pharmacology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Pharmacy --- Physiological effect --- Nanomedicine. --- Drug delivery systems. --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Pharmaceutical technology --- Medicine --- Nanotechnology --- Delivery systems --- Nanotecnologia --- Farmacologia --- Salut --- Fisiologia --- Medicina --- Condició física --- Descans --- Dieta --- Educació sanitària --- Exercici --- Hàbits sanitaris --- Longevitat --- Nutrició --- Salut pública --- Tècnica Alexander --- Medicina holística --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Toxicologia --- Medicaments --- Quimioteràpia --- Enginyeria molecular --- Tecnologia molecular --- Alta tecnologia --- Electrònica molecular --- Espintrònica --- Materials nanoestructurats --- Nanoelectrònica --- Nanolitografia --- Nanomedicina --- Nanoquímica --- Fotofarmacologia --- Chemotherapy.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.

Cancer research. --- Radiotherapy. --- Pharmacology. --- Cancer Research. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Cancer research --- Physiological effect --- Radiological services --- Radiation-sensitizing agents. --- Radiation --- Radiosensitizing agents --- Sensitizing agents --- Farmacologia --- Investigació farmacèutica --- Oncologia --- Radiologia mèdica --- Radiologia clínica --- Radiologia (Medicina) --- Física mèdica --- Medicina nuclear --- Radiofàrmacs --- Radiografia mèdica --- Radiologia dental --- Radiologia intervencionista --- Radiologia pediàtrica --- Radiologia veterinària --- Radioteràpia --- Diagnòstic radiològic --- Medicina --- Oncologia geriàtrica --- Oncologia pediàtrica --- Oncologia veterinària --- Càncer --- Infermeria oncològica --- Tumors --- Investigació farmacològica --- Investigació de medicaments --- Recerca de medicaments --- Investigació mèdica --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Resistència als medicaments --- Toxicologia --- Medicaments --- Quimioteràpia --- Fotofarmacologia --- Cancer --- Research.