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The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. This book entitled “Pharmaceutical Crystals"" focuses on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts, and hydrates, and polymorph crystals are reported. Such crystal structures were investigated in the latest studies that combined morphology, spectroscopic, theoretical calculation, and thermal analysis with crystallographic study. This book highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure–property study of pharmaceutical crystals. The Guest Editors of this book hope the readers enjoy a wide variety of recent studies on Pharmaceutical Crystals.

crystal structure analysis --- n/a --- famotidine --- solution crystallization --- salt optimization --- structure determination from powder diffraction data --- Hirshfeld surface analysis --- DFT --- molecular docking study --- melting diagram --- dehydration --- hygroscopicity --- HBV --- Benzodioxole --- pharmaceutical crystals --- 4-b]indol-4-one --- pyrimidin-4(3H)-one --- liquid assisted grinding --- HOMO-LUMO --- dissolution --- cocrystal formation --- Raman spectroscopy --- carbamazepine --- hydrogen bonding --- 3 --- ondansetron --- physicochemical properties --- solubility --- succinic acid --- cocrystal --- adefovir dipivoxil --- hepatitis B --- polymorphs --- hydrogen-bond-acceptance ability --- DFT study --- Nitrofurantoin–4-dimethylaminopyridine (NF-DMAP) salt --- photostability --- on-line monitoring --- 5-dihydro-4H-pyrimido[5 --- Imidazole --- Semicarbazone --- crystal habit --- Crystal structure --- solvent-mediated polymorphic transformation --- ticagrelor --- hydrate --- pharmaceutical cocrystal --- malonic acid --- 1H-indole --- reactivity descriptors --- famoxadone --- crystal structure --- dicarboxylic acid --- hydrogen bond --- saccharin --- Nitrofurantoin-4-dimethylaminopyridine (NF-DMAP) salt

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This book summarizes and records the recent notable advances in diverse topics in organic crystal chemistry, which has made substantial progress along with the rapid development of a variety of analysis and measurement techniques for solid organic materials. This review book is one of the volumes that are published periodically on this theme. The previous volume, published in 2015, systematically summarized the remarkable progress in assorted topics of organic crystal chemistry using organic solids and organic–inorganic hybrid materials during the previous 5 years, and it has been widely read. The present volume also shows the progress of organic solid chemistry in the last 5 years, with contributions mainly by invited members of the Division of Organic Crystal Chemistry of the Chemical Society of Japan (CSJ), together with prominent invited authors from countries other than Japan.

Inorganic chemistry --- Organic chemistry --- Chemical and physical crystallography --- Electrical engineering --- kristallografie --- organische chemie --- nanotechniek --- anorganische chemie