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Tackling socially determined inequalities in health, both between and within European Union (EU) Member States, is still a major challenge. This analysis describes the main concepts and gives examples for health inequalities across the EU. It then presents an overview of the work accomplished at international and EU levels. It shows, in particular, how the EU institutions, bodies and agencies have contributed to reducing health inequalities, notwithstanding that Member States have the main responsibility for health policy. The analysis then goes on to depict stakeholder views, before closing with an outlook on avenues for further action.