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This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide. The book first describes the total and formal synthesis of dictyodendrins A–F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine. These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compounds.

Organic chemistry. --- Catalysis. --- Inorganic chemistry. --- Chemistry. --- Medicinal chemistry. --- Pharmaceutical technology. --- Organic Chemistry. --- Inorganic Chemistry. --- Chemistry/Food Science, general. --- Medicinal Chemistry. --- Pharmaceutical Sciences/Technology. --- Physical sciences --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Inorganic chemistry --- Inorganic compounds --- Activation (Chemistry) --- Chemistry, Physical and theoretical --- Surface chemistry --- Organic chemistry --- Indole --- Chemistry, Inorganic. --- Synthesis.

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Op 16 november 2019 zou Jozef Van Hove, die de stripgeschiedenis inging onder het pseudoniem POM, honderd jaar zijn geworden. Om dat eeuwfeest luister bij te zetten lanceert Standaard Uitgeverij een integrale uitgave in elf delen van Piet Pienter en Bert Bibber, de stripreeks waar zijn naam voor altijd onlosmakelijk mee verbonden zal blijven. De reeks liep van 1951 tot 1995 op de pagina’s van Het Handelsblad en Gazet van Antwerpen. Toen de verhalen later in albums werden gebundeld, bouwden ze in heel Vlaanderen een trouwe schare fans op. Welkom in de wereld van Piet en Bert, professor Kumulus, de Amerikaanse miljardaire Susan, de zingende politieagent én POM’s alter ego, de persmuskiet Theo Flitser!

Dutch literature

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Op 16 november 2019 zou Jozef Van Hove, die de stripgeschiedenis inging onder het pseudoniem Pom, honderd jaar zijn geworden. Om dat eeuwfeest luister bij te zetten lanceert Standaard Uitgeverij een integrale uitgave in elf delen van Piet Pienter en Bert Bibber, de stripreeks waar zijn naam voor altijd onlosmakelijk mee verbonden zal blijven. De reeks liep van 1951 tot 1995 op de pagina’s van Het Handelsblad en Gazet van Antwerpen. Toen de verhalen later in albums werden gebundeld, bouwden ze in heel Vlaanderen een trouwe schare fans op. Welkom in de wereld van Piet en Bert, professor Kumulus, de Amerikaanse miljardaire Susan, de zingende politieagent én POM’s alter ego, de persmuskiet Theo Flitser!

Dutch literature --- Comic books, strips, etc.

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Fiscal vulnerabilities depend on both the level and composition of government debt. This study examines the role of debt thresholds and debt composition in driving the non-linear behavior of long-term interest rates through a novel approach, a panel smooth transition regression with a general logistic model. The main findings are threefold. First, the impact of the expected public debt level on interest rates rises exponentially when the share of foreign private holdings exceeds approximately 20 percent of government debt denominated in local currency. Second, when the share of foreign private investors is 30 percent, an increase in the share of foreign private holdings of government debt could raise long-term interest rates once the public debt-to-GDP ratio exceeds 60 percent of GDP, offsetting the downward pressure on long-term interest rates from higher market liquidity. Third, out-of-sample forecasts of this novel non-linear model are more accurate than those of previous methods.

Debt Composition --- Debt Markets --- Debt Ratio --- Debt Service Burden --- Finance and Financial Sector Development --- Generalized Panel Smooth Transition Regression --- Long-Term Interest Rate --- Private Investment --- Public and Municipal Finance --- Public Debt --- Public Sector Development

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Japanese culture is deeply rooted in nature—from literature to the visual arts, and from religious practice to daily life. How, when, and why this close association with nature developed is explored in this book by bestselling author Matsuoka Seigow. Using ten key motifs—mountains, paths, deities, wind, birds, flowers, buddhas, time, dreams, and moon—each of which serves as a lens on different aspects of Japanese culture, Matsuoka ranges from history and ethnology to the arts. He also explores the insights that emerge when traditional sensibilities are examined from the perspective of modern science. Japanese concepts of time, interval, and otherness, though arrived at intuitively, overlap with how contemporary fields such as quantum physics and relativity theory grapple with issues of uncertainty, indeterminacy, and ambiguity. Matsuoka proposes that throughout history, the phenomena of nature and the kaleidoscope of seasonal change have functioned as a system of recombinant codes for the expression of the Japanese sensibility. This unique multimedia system for the cultural construction of nature has generated the essential creative motifs of Japanese literature, fine arts, and craft, which in turn have shaped every aspect of Japanese life and thought.

Nature and nurture --- Japan --- Civilization --- J7510 --- J4150.10 --- Environment --- Genetics and environment --- Heredity and environment --- Nature --- Nature versus nurture --- Nurture and nature --- Genetics --- Heredity --- Human beings --- Japan: Science and technology -- biology -- ecology (general) --- Japan: Sociology and anthropology -- cultural history -- Kodai, prehistoric and ancient, premodern --- Nurture --- Effect of environment on --- Civilization. --- Environment and genetics --- Environment and heredity --- Nature and nurture. --- Japan - Civilization