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Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.
database --- Integrative strategies --- molecular docking --- polypharmacology --- multi-omics --- computational analysis --- Drug Repositioning --- data sharing --- Patenting
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Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.
database --- Integrative strategies --- molecular docking --- polypharmacology --- multi-omics --- computational analysis --- Drug Repositioning --- data sharing --- Patenting
Choose an application
Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.
database --- Integrative strategies --- molecular docking --- polypharmacology --- multi-omics --- computational analysis --- Drug Repositioning --- data sharing --- Patenting --- database --- Integrative strategies --- molecular docking --- polypharmacology --- multi-omics --- computational analysis --- Drug Repositioning --- data sharing --- Patenting
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China plays a variety of status games, sometimes emphasizing its status as an emerging great power and other times highlighting its status as a fragile developing country. The reasons for this are unclear. Drawing on original Chinese sources, social psychological theories, and international relations theories, this text provides a theoretically informed analysis of China's global rebranding and repositioning in the twenty-first century.
Diplomatic relations. --- China --- Foreign relations --- S09/0264 --- China: Foreign relations and world politics--General works: since 1989 --- China. --- audience. --- diplomacy. --- foreign policy. --- image. --- international relations theory. --- rebranding. --- repositioning. --- status signaling. --- status.
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