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L'utilisation des cellules souches mésenchymateuses gagne du terrain en médecine vétérinaire dans le domaine de la médecine régénérative, notamment chez le chien et le cheval pour le traitement de pathologies articulaires inflammatoires dégénératives, comme l'ostéoarthrose, pour lesquelles le vétérinaire ne dispose pas actuellement de solution curative efficace dans son arsenal thérapeutique. Cependant le manque de recul sur l'efficacité de l'injection de ces cellules dans un micro-environnement soumis à l'inflammation pourrait mener à leur emploi inutile, voire délétère. Nous nous sommes donc demandé quel était l'état des lieux des connaissances sur le comportement des cellules souches mésenchymateuses dans un milieu articulaire soumis à l'inflammation. Si in-vitro l'exposition aux cytokines inflammatoires du liquide synovial module leurs sécrétions paracrines et l'expression des marqueurs membranaires, l'injection intra-articulaire sur des modèles d'ostéoarthrite démontre leur action anti-inflammatoire et immunomodulatrice sur les cellules résidentes, leur effet chondroprotecteur, mais aussi leur faible persistance dans le milieu intra-articulaire inflammé. Au niveau des résultats cliniques, si les cellules souches mésenchymateuses en intra-articulaire sont sûres et efficaces pour réduire en partie les signes cliniques de l'ostéoarthrose, les nombreuses variations de nature et de qualité des produits cellulaires utilisés empêche actuellement une évaluation objective de l'impact réel de ce traitement.

Mesenchymal stem cells --- joint inflammation --- intra-articular injection --- osteoarthritis --- anti-inflammatory properties --- immunomodulation --- paracrine effect --- chondroprotection --- Sciences du vivant > Médecine vétérinaire & santé animale

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This book presents exclusive and comprehensive insight into the detailed molecular mechanisms of osteoarthritis (OA) initiation, progression and current advancements in the field. Inputs from clinician scientists, research and expertise offer a complete explanation of the current understanding of the pathogenesis of OA and practice in imaging and treatments strategies. Contributions from leading scientists provide a detailed introduction in the use of biomarkers in clinical research as well as in clinical practice and OA diagnosis. This book further discusses the potential of regenerative therapies and recent advances in cardiovascular and functional capacity on patients with OA.

Microbiology. --- Osteoarthritis --- Biochemical markers. --- Treatment. --- Biologic markers --- Biological markers --- Biomarkers --- Markers, Biochemical --- Biochemistry --- Indicators (Biology) --- Degenerative arthritis --- Degenerative joint disease --- Joint disease, Degenerative --- OA (Disease) --- Old age arthritis --- Osteoarthrosis --- Wear and tear arthritis --- Arthritis --- Microbial biology --- Biology --- Microorganisms --- Medicine --- Immunology --- Osteoimmunology --- Allergology and Rheumatology --- Health Sciences

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This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.

n/a --- biomaterial --- redifferentiation --- regenerative medicine --- skeletal muscle regeneration --- furcation defects --- Platelet-Rich Plasma (PRP) --- PRP --- fracture --- fibrin sealant --- periodontal surgery --- bone regeneration --- serum derived from plasma rich in growth factors (s-PRGF) --- cartilage repair --- myofibroblasts --- autologous platelet concentrates --- burns --- satellite cells --- articular cartilage --- stem cell niche --- wound healing --- quantification --- growth factors --- biologics --- platelet rich plasma --- meniscus --- adipose tissue --- Carprofen --- platelet-rich fibrin --- platelets --- hyperacute serum --- bone defects --- serum eye drops --- corneal epithelial defect --- fibrosis --- dog --- myoblasts --- differentiation --- chronic meniscal lesion --- horizontal meniscal tear --- PRGF --- collagen hydrogels --- periodontal defects --- bone grafting material --- composition --- cell therapy --- bone healing --- tissue healing --- trephination --- plasma rich plasma (PRP) --- bone repair --- plasma rich in growth factors --- knee arthrosis --- meniscus tear --- cornea regeneration --- wrist osteoarthritis --- periosteal sheet --- Platelet-Poor Plasma (PPP) --- platelet-rich plasma --- microfat --- bone grafting --- hyaluronic acid (NaHA) --- periodontal regeneration --- meniscus repair --- photobiomodulation therapy --- growth --- myogenesis --- blood derived products --- low-level laser therapy