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The toxicity and fate of pharmaceuticals and other emerging micro-organic contaminants in the natural and built environments have been the focus of much research over the last twenty years. Particular focus has recently centred on the fate of antimicrobial chemicals, including antibiotics and antifungals. The occurrence of such chemicals in the environment is thought to contribute to the selection of resistance in exposed microorganisms.This Special Issue (SI) brings together a broad range of recent advances in the field of emerging micro-organic contaminants, ranging from medicinal contaminants to industrial chemicals in the environment. Notably, these range from chemical extraction and large-scale analysis to adverse effects on non-target aquatic organisms and potential risk to humans via contaminated foodstuffs. Additionally, this Special Issue also presents novel contaminant treatment/degradation methods of both physical and biological nature.

chitosan --- risk assessment --- n/a --- di(2-ethylhexyl) phthalate (DEHP) --- Escherichia coli --- picolinic acid --- degradation --- 6-hydroxypicolinic acid --- biosorption --- coagulation --- qPCR --- global monitoring --- Pseudomonas putida --- basic buffer --- validation --- ethyl tert-butyl ether --- wastewater --- sewage treatment --- crustacean --- ETBE biodegradation --- ethB gene --- veterinary drug --- water quality --- tetracyclines --- micropollutants --- bacterial community --- antibiotics --- Membrane Bioreactor --- UPLC MS/MS --- bisphenol A (BPA) --- GAC-biofilter --- shrimp --- vitellogenin (VTG) --- hormones --- polluted aquifer --- biodegradation --- Rhodococcus --- sewage sludge --- ion suppression --- ozone --- pharmaceutical residues --- beta-lactams --- espresso coffee machine extraction --- mass spectrometry --- dye decolorization --- chlorination --- pressurized hot water extraction --- immobilization --- ARGs --- pharmaceuticals --- organic pollutants --- residue --- perfluorinated compounds --- liquid chromatography tandem mass spectrometry --- activated carbon --- irgarol --- fuel oxygenates

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Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.

human liver microsomes --- alcohol addiction --- UGT --- ultra-high-pressure liquid chromatography --- adalimumab --- procainamide --- LC-MS/MS --- DA-9805 --- paeonol --- LC-QTOF-MS/MS --- YRA-1909 --- chlorogenic acid --- immunoprecipitation --- Eurycoma longifolia --- CYP --- caffeic acid --- rat --- pharmaceutical excipient --- Korean red ginseng extract --- Stauntonia hexaphylla leaf extract --- bioanalysis --- HPLC-MS/MS --- B6 --- eurycomanone --- bioavailability --- drying technology --- GB3 --- diclofenac --- 129-Glatm1Kul/J --- aglycone --- caffeic acid O-glucuronides --- organic anion transporting polypeptide --- protein precipitation --- metabolic stability --- Fabry disease --- biopharmaceuticals --- imperatorin --- neochlorogenic acid --- gastric ulcer --- saikosaponin a --- hair --- anthraquinone --- acetyl tributyl citrate --- pharmacokinetics --- brain distribution --- mematine --- ethyl glucuronide --- pharmacokinetic --- loxoprofen --- liquid chromatography-quadrupole TOF MS --- glucuronidation --- esomeprazole --- metformin --- cytochrome P450 --- glycoside --- AUDIT score --- protein stability --- efficacy --- LC-HR/MS --- cryptochlorogenic acid --- aceclofenac --- drug interaction --- liquid chromatography-tandem mass spectrometry --- Osthenol --- plasma --- N-acetylprocainamide --- diabetes --- Drugs --- Metabolism. --- Drug metabolism --- Pharmacokinetics

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This book will provide the most recent knowledge and advances in Sample Preparation Techniques for Separation Science. Everyone working in a laboratory must be familiar with the basis of these technologies, and they often involve elaborate and time-consuming procedures that can take up to 80% of the total analysis time. Sample preparation is an essential step in most of the analytical methods for environmental and biomedical analysis, since the target analytes are often not detected in their in-situ forms, or the results are distorted by interfering species. In the past decade, modern sample preparation techniques have aimed to comply with green analytical chemistry principles, leading to simplification, miniaturization, easy manipulation of the analytical devices, low costs, strong reduction or absence of toxic organic solvents, as well as low sample volume requirements.Modern Sample Preparation Approaches for Separation Science also provides an invaluable reference tool for analytical chemists in the chemical, biological, pharmaceutical, environmental, and forensic sciences.

caffeine and acetaminophen tracers --- solvent delivery with a moving pipette --- determination --- China herbal tea --- enrichment --- review --- on-line --- pectin --- nanocomposite --- Cassiae Semen --- environmental analysis --- pathogenic --- preconcentration --- nail --- liver --- extraction --- sample preparation --- hydrogel --- solid-phase extraction --- geological samples --- ionic liquids --- rice grains --- subzero-temperature assisted liquid–liquid extraction --- sugaring-out assisted liquid–liquid extraction --- poly (OMA-co-TRIM) monolithic column --- hormones --- vortex-synchronized matrix solid-phase dispersion --- trace analysis --- gas chromatography --- LC–MS/MS --- membrane-based microextraction --- gold --- antipsychotics --- in-line filter --- HPLC --- space instrumentation --- liquid chromatography --- biological samples --- vitamins --- polyvinyl alcohol --- in-tube SPME --- high-frequency heating --- UPLC-MS/MS --- oxylipins --- nucleic acid isolation --- non-anthocyanin polyphenol --- large volume --- barbiturates --- solvent front position extraction --- oligopeptides --- urine --- SPE --- whole blood --- anthraquinones --- flow rate --- chlorophenoxy acid herbicides --- amlodipine --- schizophrenic’ patients --- salting-out assisted liquid–liquid extraction --- automation --- sorbent --- whole water --- blueberry --- hydrophobic-solvent assisted liquid–liquid extraction --- crab shells --- miniaturization --- curie temperature --- sand --- UHPLC-MS/MS --- multi-spheres adsorptive micro-extraction (MSA?E) --- floating sampling technology --- protein precipitation --- pesticides residue --- sample preparation with TLC/HPTLC --- phenolic compounds --- response surface methodology --- vortex-assisted dispersive liquid-liquid microextraction --- trapping system --- caffeine --- aflatoxins --- liquid chromatography–tandem mass spectrometry --- pesticides --- organic-based monoliths --- matrix solid phase dispersion --- simultaneous determination --- pharmaceuticals --- sorbent-based techniques --- desirability function approach --- plasma samples --- environmental water matrices --- hydrophobic in-tube solid-phase microextraction --- liquid–liquid extraction