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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Infectious & contagious diseases --- Plasmodis --- Toxoplasma --- Toxoplasmosis --- Malaria --- Trypanosoma --- Giardia --- artemisin --- protozoa --- protozoan --- Vaccines --- chimioinformatics --- reverse vaccines --- Immunomodulation --- Toxoplasma --- Toxoplasmosis --- Malaria --- Trypanosoma --- Giardia --- artemisin --- protozoa --- protozoan --- Vaccines --- chimioinformatics --- reverse vaccines --- Immunomodulation

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Major depression and obsessive–compulsive disorder (OCD) are now recognized among the most frequent psychiatric disorders, affecting 16–17% and 2–3% of the general population, respectively. They are commonly characterized by: i) a high level of psychiatric and somatic comorbidities; ii) a recurrence or chronic profile; and iii) a negative impact on daily functions, thereby leading to a profound impairment of quality of life. Despite significant advances in pharmacological and psychological therapies over the last decades, unsuccessful responses to standard treatment strategies are classically observed in approximately 20–30% of cases. Therefore, there is a significant need for improving the pathophysiological knowledge through a better identification of environmental, clinical, psychological, genetic, anatomical, and biological determinants, specifically implied in the development, the phenotypic expression, and the relapsing course and/or contributing to the therapeutic failure in major depression and OCD. We are convinced that this research approach is particularly relevant providing critical support for the promotion of innovative treatment alternatives potentially useful for the management of resistant forms of major depression and OCD.

n/a --- i-health --- olfaction --- psychiatry --- obsession --- obsessive–compulsive disorder --- transcranial direct current stimulation --- ecological momentary assessment --- Streptococcus pyogenes --- cytokines --- immunology --- compulsion --- cognition --- nosography --- pediatric autoimmune neuropsychological disorders associated with streptococcal infection (PANDAS) --- symptoms networks --- brain stimulation --- neuromodulation --- OCD --- m-health --- categorizations --- ecological momentary intervention --- fictional case study --- pediatric acute-onset neuropsychiatric syndrome (PANS) --- Toxoplasma gondii --- tDCS --- therapeutic tool --- depression --- markers --- quality of life --- Tourette syndrome --- Obsessive-compulsive disorder. --- Depression, Mental. --- Dejection --- Depression, Unipolar --- Depressive disorder --- Depressive psychoses --- Melancholia --- Mental depression --- Unipolar depression --- Affective disorders --- Neurasthenia --- Neuroses --- Manic-depressive illness --- Melancholy --- Sadness --- Compulsive disorder --- Fixed ideas --- Obsession (Psychology) --- Obsessive-compulsive neuroses --- Obsessive-compulsive neurosis --- OCD (Disease) --- Compulsive behavior --- Bipolar disorder --- obsessive-compulsive disorder