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Particularly in healthcare fields, there is growing movement away from traditional lecture style course towards active learning and team-based activities to improve learning and build higher level thinking through application of complex problems with a strong foundation of facts and data. Essential Pharmaceutics is suited to this modern teaching style, and is the first book of its kind to provide the resources and skills needed for successful implementation of an active learning pharmaceutics course.This text offers a format that is specifically suited for integration in an active learning, team-based classroom setting. It is ideal for self-learning for the beginning pharmaceutics student, based upon the extensive utilization of figures, tables, and its overview of essential topics in pharmaceutics. Also unique to this text is the integration of case studies based upon modern pharmaceutical products which are designed to reinforce importance pharmaceutical concepts and teach essential skills in literature review and patent searching. Case studies covering all topics covered in the text have been developed by the authors that allow application of the content in the flipped-classroom pharmaceutical course.

Pharmaceutical technology. --- Pharmacy. --- Pharmaceutical Sciences/Technology. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology --- Tecnologia farmacèutica --- Farmàcia galènica --- Tècnica farmacèutica --- Tècniques farmacèutiques --- Tecnologies farmacèutiques --- Anàlisi de medicaments --- Biotecnologia farmacèutica --- Dispositius d'administració de medicaments --- Síntesi de fàrmacs --- Sistemes d'alliberament de medicaments --- Farmàcia

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The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc. .

Pharmaceutical technology. --- Proteins . --- Biomedical engineering. --- Pharmaceutical Sciences/Technology. --- Protein Science. --- Protein Structure. --- Biomedical Engineering/Biotechnology. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Allosteric proteins. --- Proteins --- Proteins, Allosteric --- Cooperative binding (Biochemistry) --- Protein binding --- Allosterism --- Tecnologia farmacèutica --- Farmàcia galènica --- Tècnica farmacèutica --- Tècniques farmacèutiques --- Tecnologies farmacèutiques --- Anàlisi de medicaments --- Biotecnologia farmacèutica --- Dispositius d'administració de medicaments --- Síntesi de fàrmacs --- Sistemes d'alliberament de medicaments --- Farmàcia --- Proteins.

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This book closes a current gap by providing the scientific basis for consumer exposure assessment in the context of regulatory risk assessment. Risk is defined as the likelihood of an event occurring and the severity of its effects. The margin between the dose that leads to toxic effects and the actual dose of a chemical is identified by estimating population exposure. The objective of this book is to provide an introduction into the scientific principles of consumer exposure assessment, and to describe the methods used to estimate doses of chemicals, the statistics applied and computer tools needed. This is presented through the backgrounds of the special fields in exposure analysis, such as exposure via food and by the use of consumer products, toys, clothing and other items. As a general concept, human exposure is also understood to include exposure via the environment and from the work setting. In this context, the specific features of consumer exposure are pointed out and put into the context of regulation, in particular food safety, chemicals safety (REACh) and consumer product safety. The book is structured into three parts: The first part deals with the general concepts of consumer exposure as part of the overall risk analysis framework of risk characterization, risk assessment and risk communication. It describes the three basic features of exposure assessment (i) the exposure scenario (ii) the exposure model and (iii) the exposure parameters, addressing external and internal exposure. Also, the statistical presentation of data to characterize populations, in connection with variability, uncertainty and quality of information and the presentation of exposure evaluation results is described. The second part deals with the specific issues of exposure assessment, exposure via food consumption, exposure from use of consumer products, household products, toys, cosmetic products, textiles, pesticides and others. This part also covers methods for acquisition of data for exposure estimations, including the relevant information from regulations needed to perform an accurate exposure assessment. The third part portrays a prospect for further needs in the development and improvement of consumer exposure assessment, as well as international activities and descriptions of the work of institutions that are involved in exposure assessment on the regulatory and scientific level. And conversely, it creates the rationale for the exposure assessment details necessary to satisfy regulatory needs such as derivation of upper limits and risk management issues.

Pharmaceutical technology. --- Occupational medicine. --- Chemistry. --- Pharmaceutical Sciences/Technology. --- Occupational Medicine/Industrial Medicine. --- Safety in Chemistry, Dangerous Goods. --- Industrial medicine --- Medicine, Occupational --- Occupational medicine --- Medicine --- Occupational diseases --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Physical sciences --- Tecnologia farmacèutica --- Farmàcia galènica --- Tècnica farmacèutica --- Tècniques farmacèutiques --- Tecnologies farmacèutiques --- Anàlisi de medicaments --- Biotecnologia farmacèutica --- Dispositius d'administració de medicaments --- Síntesi de fàrmacs --- Sistemes d'alliberament de medicaments --- Farmàcia --- Medicine, Industrial.

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This book provides practical guidance on all aspects of reverse phase protein array (RPPA) technology, which permits the quantification of protein levels in cell or tissue lysates. In addition, the latest results are presented from laboratories across the world where experts are successfully running the challenging RPPA data platform. After an introductory chapter by the inventor of the RPPA technique, the demanding task of lysate preparation is explained. Subsequent chapters review printing platforms and analytical platforms and discuss antibody screening in detail. The role of RPPA data in integrative analyses is thoroughly examined, and the various applications of RPPA, for example to identify molecular targeting drugs or evaluate cancer drug efficacy, are discussed with reference to the latest knowledge. It is hoped that the book will foster the implementation of RPPA by documenting the practical details of the technology and by revealing its great potential. It will be of high value for researchers who plan to build an RPPA platform in their institute and for researchers, clinicians, and companies who use RPPA through collaboration with an existing RPPA facility.

Proteins. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Molecular biology. --- Cancer research. --- Proteins . --- Biomedical engineering. --- Microarrays. --- Pharmaceutical technology. --- Molecular Medicine. --- Cancer Research. --- Protein Science. --- Biomedical Engineering/Biotechnology. --- Pharmaceutical Sciences/Technology. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Systems biology --- Enginyeria de proteïnes --- Tecnologia farmacèutica --- Farmàcia galènica --- Tècnica farmacèutica --- Tècniques farmacèutiques --- Tecnologies farmacèutiques --- Anàlisi de medicaments --- Biotecnologia farmacèutica --- Dispositius d'administració de medicaments --- Síntesi de fàrmacs --- Sistemes d'alliberament de medicaments --- Farmàcia --- Disseny de proteïnes --- Tecnologia de proteïnes --- Enginyeria bioquímica --- Enginyeria genètica --- Cancer --- Research.

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This book examines the current and controversial topic of the sulphur cap in maritime supply chains, a new regulation set to be enforced in 2020. The author presents extensive research on three northern countries - Finland, Sweden and Estonia - and the effects they felt when these regulations were rolled out in 2015. These regional case studies are presented alongside extensive private sector data, annual reports and interviews to assess and forecast how the maritime supply chain will cope with rising costs and alternative approaches to environmental regulations. This book includes advanced regression analyses alongside interactive simulation models for the reader to evaluate new supply chain strategies and study the effects of these regulations.

Sulfur compounds --- Environmental aspects --- Law and legislation. --- Business logistics. --- Industrial management-Environmen. --- Environmental management. --- Supply Chain Management. --- Corporate Environmental Management. --- Sustainability Management. --- Environmental Management. --- Supply chain management --- Industrial management --- Logistics --- Environmental stewardship --- Stewardship, Environmental --- Environmental sciences --- Management --- maritime transport --- reduction of gas emissions --- natural gas --- sulphur --- case study --- Finland --- Estonia --- Sweden --- transporte marítimo --- námořní doprava --- námorná doprava --- transport maritim --- transport detar --- морски транспорт --- trasporto marittimo --- jūrų transportas --- jūras transports --- поморски превоз --- meretransport --- sjötransport --- meriliikenne --- Beförderung auf dem Seeweg --- transport maritime --- søtransport --- vervoer over zee --- transport morski --- θαλάσσια μεταφορά --- pomorski prijevoz --- tengeri szállítás --- morski prevoz --- trasport marittimu --- tengeri közlekedés --- meriliikenneväylä --- trasporto marittimo comunitario --- morská doprava --- morski prijevoz --- havforbindelse --- lidhje me transport detar --- trafik detar --- sea transport connection --- căi de navigație maritime --- collegamento marittimo --- trasporto via mare --- meriväylä --- Beförderung im Seeverkehr --- søtrafik --- lidhje detare --- kuģu satiksme --- sjötrafik --- Seeverbindung --- prijevoz morem --- seagoing traffic --- premávka na mori --- merevedu --- pomorski promet --- tráfego marítimo --- θαλάσσια κυκλοφορία --- tengeri összeköttetés --- превоз по морски пат --- trasporto marittimo mondiale --- trafic maritime --- Seeverkehr --- jūrų susisiekimas --- compagnia di navigazione --- compagnia marittima --- maritime connection --- laevaliiklus --- susisiekimas jūrų transportu --- ligação marítima --- jūras pārvadājumi --- liaison maritime --- tolimoji jūrų laivyba --- námorné spojenie --- zeeverbinding --- traffico marittimo --- sea transport --- mereühendus --- mořeplavec --- námořní přeprava --- relazioni marittime --- søforbindelse --- námořní komunikace --- zeeverkeer --- trafic maritim --- námořní provoz --- transport pe mare --- sjöförbindelse --- legatură maritimă --- morské dopravné spojenie --- tráfico marítimo --- θαλάσσια σύνδεση --- mereveondus --- An tSualainn --- Suedia --- Rootsi --- Suède --- Svédország --- Швеция --- l-Iżvezja --- Σουηδία --- Шведска --- Švédsko --- Zweden --- Svezia --- Švedija --- Švedska --- Suécia --- Sverige --- Ruotsi --- Suecia --- Schweden --- Zviedrija --- Szwecja --- Kraljevina Švedska --- Regatul Suediei --- Kingdom of Sweden --- Švédske kráľovstvo --- Koninkrijk Zweden --- Svéd Királyság --- Regno di Svezia --- Reino de Suecia --- Mbretëria e Suedisë --- Краљевина Шведска --- Кралство Швеция --- Кралство Шведска --- Royaume de Suède --- Βασίλειο της Σουηδίας --- Ruotsin kuningaskunta --- Rootsi Kuningriik --- das Königreich Schweden --- Kongeriget Sverige --- ir-Renju tal-Iżvezja --- Švédské království --- Królestwo Szwecji --- Zviedrijas Karaliste --- Konungariket Sverige --- Reino da Suécia --- Švedijos Karalystė --- Estónsko --- Estland --- Estónia --- Estonija --- Εσθονία --- Estonie --- l-Estonja --- An Eastóin --- Estija --- Estonsko --- Eesti --- Естонија --- Viro --- Igaunija --- Észtország --- Естония --- ir-Repubblika tal-Estonja --- Viron tasavalta --- Republic of Estonia --- Estonská republika --- Republikken Estland --- Republika Estońska --- République d’Estonie --- Eesti Vabariik --- República da Estónia --- Република Естония --- die Republik Estland --- Republika e Estonisë --- Republika Estonija --- Republiek Estland --- Republica Estonia --- Észt Köztársaság --- Република Естонија --- República de Estonia --- Republiken Estland --- Igaunijas Republika --- Estijos Respublika --- Estónska republika --- Δημοκρατία της Εσθονίας --- Repubblica di Estonia --- An Fhionlainn --- Soome --- Suomija --- il-Finlandja --- Finlande --- Finlândia --- Finnland --- Fínsko --- Финландия --- Somija --- Suomi --- Φινλανδία --- Finsko --- Финска --- Finnország --- Finlanda --- Finlandia --- Finska --- Finn Köztársaság --- Suomijos Respublika --- Φιλλανδία --- République de Finlande --- Republika Finska --- Republica Finlanda --- Republiek Finland --- Република Финландия --- ir-Repubblika tal-Finlandja --- Suomen tasavalta --- Fínska republika --- Republika Finlandii --- Republika e Finlandës --- Finská republika --- República de Finlandia --- Republiken Finland --- Repubblica di Finlandia --- República da Finlândia --- Soome Vabariik --- Somijas Republika --- Republic of Finland --- Δημοκρατία της Φινλανδίας --- Republikken Finland --- die Republik Finnland --- Република Финска --- esettanulmány --- rast studimor --- περιπτωσιολογική μελέτη --- prípadová štúdia --- casestudy --- fallstudie --- cás-staidéar --- atvejo tyrimas --- studiu de caz --- анализа случаја --- estudo de casos --- gadījumu izpēte --- студија на случај --- Fallstudie --- estudio de casos --- juhtumiuuring --- tapaustutkimus --- étude de cas --- případová studie --- studia przypadków --- изучаване на процеса --- analiza slučaja --- študija primera --- studio di fattispecie --- studju tal-każijiet --- estudio de caso práctico --- estudio de casos típicos --- gadījumu studijas --- case-study --- análisis de casos típicos --- problemos nagrinėjimas --- анализа на случај --- детално проучување на случај --- análisis de ejemplos concretos --- studija slučaja --- estudio de casos concretos --- estudio de ejemplos prácticos --- proučavanje slučaja --- детално следење на случај --- sulfar --- svovl --- сулфур --- svavel --- zwavel --- síra --- siera --- sumpor --- kén --- väävel --- žveplo --- squfur --- enxofre --- soufre --- azufre --- sulfură --- θείον --- Schwefel --- сяра --- kubrit --- zolfo --- sērs --- siarka --- сумпор --- rikki --- θειάφι --- zemni plin --- gás natural --- aardgas --- gaz natyror --- naturgas --- zemní plyn --- földgáz --- природни гас --- gass naturali --- φυσικό αέριο --- gaz ziemny --- gaz naturel --- zemný plyn --- gaze naturale --- природен газ --- gas natural --- земен гас --- maagaas --- maakaasu --- gás nádúrtha --- dabasgāze --- gas naturale --- gamtinės dujos --- Erdgas --- zemeljski plin --- природен гас --- gas naturale di sintesi --- looduslik gaas --- Naturgas --- gaasiheidete vähendamine --- gázkibocsátás csökkentése --- minskade gasutsläpp --- reducción de las emisiones de gas --- kaasupäästöjen vähentäminen --- smanjenje emisija plina --- redução das emissões de gases --- réduction des émissions de gaz --- μείωση των εκπομπών αερίων --- riduzione delle emissioni gassose --- Verringerung der Emissionen von Treibhausgasen --- reduktion af gasemissioner --- snižování plynných emisí --- vermindering van gasemissie --- намаляване на емисиите --- ograniczenie emisji gazów --- reducerea emisiilor de gaze cu efect de seră --- tnaqqis tal-emissjonijiet --- gāzu emisijas samazināšana --- laghdú astaíochtaí --- pakësimi i emetimeve të gazeve --- смањење емисија гаса --- znižovanie emisií plynov --- zmanjšanje emisij plinov --- намалување на емисиите на гас --- išmetamųjų dujų kiekio mažinimas --- mitigation of climate change --- masë zbutëse --- Verringerung der Treibhausgasemissionen --- zbutje e ndryshimit klimaterik --- emissionsreduktion --- мерки за ублажување --- mitigation measure --- kibocsátáscsökkentés --- päästövähennys --- snižování emisí skleníkových plynů --- gasemissievermindering --- päästövähenemä --- päästöjen vähennys --- мерки за ублажување на климатските промени --- udslipsreduktion --- minskade utsläpp av växthusgaser --- climate change mitigation --- politique d'atténuation du changement climatique --- ulje e emetimit të gazrave --- politikë zbutjeje --- mitigation policy --- περιορισμός των εκπομπών αερίων --- ублажување на климатските промени --- reducción de emisión --- mesure d'atténuation du changement climatique --- gas emission reduction --- riduzione delle emissioni --- znižovanie emisií --- μείωση των εκπομπών --- zníženie emisií --- zmanjšanje emisij --- redução de emissões --- atténuation du changement climatique --- Emissionsreduktion --- намаляване на емисиите на отработени газове --- utsläppsminskning --- redukcja emisji --- gasemissiereductie --- emisiju samazināšana --- emissiereductie --- Emissionsminderung --- heitkoguste vähendamine --- snižování emisí --- политика за ублажување --- réduction d'émission --- emissiooni vähendamine --- emissziócsökkentés --- išmetamųjų teršalų mažinimas --- išmetamųjų dujų mažinimas --- reducere a emisiilor --- Industrial management—Environmental aspects. --- Environmental aspects.