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Personalized and precision medicine (PPM)-the targeting of therapies according to an individual's genetic, environmental, or lifestyle characteristics-is becoming an increasingly important approach in health care treatment and prevention. The advancement of PPM is a challenge in traditional clinical, reimbursement, and regulatory landscapes because it is costly to develop and introduces a wide range of scientific, clinical, ethical, and socioeconomic issues. PPM raises a multitude of economic issues, including how information on accurate diagnosis and treatment success will be disseminated and who will bear the cost; changes to physician training to incorporate genetics, probability and statistics, and economic considerations; questions about whether the benefits of PPM will be confined to developed countries or will diffuse to emerging economies with less developed health care systems; the effects of patient heterogeneity on cost-effectiveness analysis; and opportunities for PPM's growth beyond treatment of acute illness, such as prevention and reversal of chronic conditions. This volume explores the intersection of the scientific, clinical, and economic factors affecting the development of PPM, including its effects on the drug pipeline, on reimbursement of PPM diagnostics and treatments, and on funding of the requisite underlying research; and it examines recent empirical applications of PPM.

Pharmacogenetics. --- Personalized medicine --- Economic aspects --- genetic testing. --- insurance coverage. --- personalized medicine. --- screening. --- stratified medicine. --- tailored medicine. --- targeted medicine. --- Precision medicine

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Pharmacogenetics. --- Epigenomics. --- Epigenesis, Genetic. --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Epigenome --- DNA Methylation --- Epigenetics --- Epigenetic --- Epigenomic --- Pharmacogenomics --- Pharmacogenomic Variants --- Drug Resistance --- Toxicology --- Precision Medicine --- Pharmacology --- Biochemical genetics --- Genetic aspects

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Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. -- Publisher

Personalized medicine. --- Precision Medicine. --- P Health --- P-Health --- Personalized Medicine --- Individualized Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- P-Healths --- Pharmacogenomic Variants --- Pharmacogenetics --- Patient-Specific Modeling --- Individualized medicine --- Medical care --- Theranostics --- Predictive Medicine --- Medicine, Predictive --- Theranostic --- Precision medicine. --- Personalized medicine --- Epigenetics. --- Precision Medicine --- Epigenomics.

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toxicology --- natural toxins --- poisoning --- venom --- antivenom --- Toxins --- Venom --- Venom. --- Toxins. --- Toxicology. --- Toxins, Biological. --- Biological Toxins --- Toxoids --- Evidence Based Toxicology --- Evidence-Based Toxicology --- Toxinology --- Based Toxicologies, Evidence --- Based Toxicology, Evidence --- Evidence Based Toxicologies --- Evidence-Based Toxicologies --- Toxicologies, Evidence Based --- Toxicologies, Evidence-Based --- Toxicology, Evidence Based --- Toxicology, Evidence-Based --- Pharmacogenetics --- Natural toxicants --- Toxicants, Natural --- Antigens --- Metabolites --- Poisons --- Antitoxins --- Detoxification (Health) --- Venoms --- Antivenins --- Poisonous animals --- Toxins and antitoxins

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"Evolution's Clinical Guidebook: Translating Ancient Genes into Precision Medicine demonstrates, through well-documented examples, how an understanding of the phylogenetic ancestry of humans allows us to make sense out of the flood of genetic data streaming from modern laboratories and how it can lead us to new ways to prevent, diagnose and treat diseases. Topics cover evolution and human genome, meiosis and other recombinants events, embryology, speciation, phylogeny, rare and common diseases, and the evolution of aging. This book is a valuable source for bioinformaticians and those in the biomedical field who need knowledge, down to gene level, to fully comprehend currently available data." --Amazon.ca.

Genetics --- Data processing. --- Personalized medicine. --- Bioinformatics. --- Genomics. --- Genetic Phenomena. --- Biological Evolution. --- Precision Medicine. --- P Health --- P-Health --- Personalized Medicine --- Individualized Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- P-Healths --- Pharmacogenomic Variants --- Pharmacogenetics --- Patient-Specific Modeling --- Evolution, Biological --- Sociobiology --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Genetic Processes --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Molecular Biology --- Genome research --- Genomes --- Molecular genetics --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Individualized medicine --- Medical care --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Research --- Data processing --- Theranostics --- Predictive Medicine --- Medicine, Predictive --- Theranostic --- Precision medicine. --- Personalized medicine