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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Science: general issues --- Medical genetics --- toxicogenomics --- Gene Expression --- Toxicology --- chemicals --- exposures --- mode of action --- integration --- bioinformatics --- gene regulatory network --- Next-generation sequencing --- toxicogenomics --- Gene Expression --- Toxicology --- chemicals --- exposures --- mode of action --- integration --- bioinformatics --- gene regulatory network --- Next-generation sequencing
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
toxicogenomics --- Gene Expression --- Toxicology --- chemicals --- exposures --- mode of action --- integration --- bioinformatics --- gene regulatory network --- Next-generation sequencing
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Science: general issues --- Medical genetics --- antibiotic resistance --- next generation sequencing --- mobile genetic element --- horizontal gene transfer --- Mutation Rate --- infectious diseases --- resistome --- New Antibiotic Target --- Direct Evolution Experiment
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Science: general issues --- Medical genetics --- toxicogenomics --- Gene Expression --- Toxicology --- chemicals --- exposures --- mode of action --- integration --- bioinformatics --- gene regulatory network --- Next-generation sequencing
Choose an application
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
antibiotic resistance --- next generation sequencing --- mobile genetic element --- horizontal gene transfer --- Mutation Rate --- infectious diseases --- resistome --- New Antibiotic Target --- Direct Evolution Experiment
Choose an application
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Science: general issues --- Medical genetics --- antibiotic resistance --- next generation sequencing --- mobile genetic element --- horizontal gene transfer --- Mutation Rate --- infectious diseases --- resistome --- New Antibiotic Target --- Direct Evolution Experiment --- antibiotic resistance --- next generation sequencing --- mobile genetic element --- horizontal gene transfer --- Mutation Rate --- infectious diseases --- resistome --- New Antibiotic Target --- Direct Evolution Experiment
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Precision medicine is rapidly becoming the standard-of-care for the treatment of cancer patients. This is made possible, in part, by the ready availability and reasonable costs of comprehensive DNA and RNA sequencing assays. However, precision medicine is complex and incorporates entirely new types of data and treatment paradigms that are outside of the training of most oncologists in practice today. Precision Medicine Oncology: A Primer is a concise review of the fundamental principles and applications of precision medicine, intended for clinicians, particularly those working in oncology. It provides an accessible introduction to the technological advances in DNA and RNA sequencing, gives a detailed overview of approaches to the interpretation of molecular test results and their point-of-care implementation for individual patients, and describes innovative clinical trial designs in oncology as well as characteristics of the computational infrastructures through which massive quantities of data are collected, stored, and used in precision medicine oncology.
Tumors --- Medical Oncology --- Precision Medicine --- Neoplasms --- Tumours --- Pathology --- Cysts (Pathology) --- Oncology --- therapy. --- Individualized medicine --- Personalized medicine --- Medical care --- Pharmacogenetics --- Medicine, oncology, precision medicine, cancer, cancer treatment, cancer patients, clinicians, medical practice, DNA, RNA, comprehensive DNA sequencing, comprehensive RNA sequencing, technological advances, molecular test results, oncologists, medical students, fellows in oncology, nurses, physician assistants, molecular tumor board, next-generation sequencing, comprehensive genomic profiling, individualized medicine.
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The contribution of genomic variants to the aetiopathogenesis of both paediatric and adult neurological disease is being increasingly recognized. The use of next-generation sequencing has led to the discovery of novel neurodevelopmental disorders, as exemplified by the deciphering developmental disorders (DDD) study, and provided insight into the aetiopathogenesis of common adult neurological diseases. Despite these advances, many challenges remain. Correctly classifying the pathogenicity of genomic variants from amongst the large number of variants identified by next-generation sequencing is recognized as perhaps the major challenge facing the field. Deep phenotyping (e.g., imaging, movement analysis) techniques can aid variant interpretation by correctly classifying individuals as affected or unaffected for segregation studies. The lack of information on the clinical phenotype of novel genetic subtypes of neurological disease creates limitations for genetic counselling. Both deep phenotyping and qualitative studies can capture the clinical and patient’s perspective on a disease and provide valuable information. This Special Issue aims to highlight how next-generation sequencing techniques have revolutionised our understanding of the aetiology of brain disease and describe the contribution of deep phenotyping studies to a variant interpretation and understanding of natural history.
polymicrogyria --- n/a --- neurodegenerative disease --- next generation sequencing (NGS) --- inborn error of metabolism --- genetic biomarker --- deep learning --- TUBA1A --- Alzheimer’s disease (AD) --- ataxia --- risk prediction --- p.(Arg2His) --- movement science --- tubulin --- R2H --- diagnosis --- machine learning --- metal storage disorders --- amyotrophic lateral sclerosis (ALS) --- glucocerebrosidase --- Parkinsonism --- cerebellar hypoplasia --- Gaucher disease --- disease phenotyping --- tubulinopathy --- Parkinson’s disease (PD) --- dementia --- Parkinson’s disease --- Neurogenetics. --- Nervous system --- Genetics --- Neurosciences --- Genetic aspects --- Alzheimer's disease (AD) --- Parkinson's disease (PD) --- Parkinson's disease
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Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases.
n/a --- liver graft injury --- HFE --- neurokinin --- chemotherapy --- intestinal tumors --- therapeutic targets --- biliary tract carcinoma --- hepatocellular carcinoma --- clinical trial --- cell adhesion molecules --- colorectal cancer --- biomarkers --- phenotypic mosaics --- gastrointestinal oncology --- Asian Cancer Research Group (ACRG) --- biomarker --- psychosocial support --- precision therapy --- pancreatic carcinoma --- precision medicine --- Liver transplantation --- predictive biomarkers --- CD274 --- cholecystokinin --- The Cancer Genome Atlas (TCGA) --- gastrin --- pembrolizumab --- immunotherapy --- gastrin-releasing peptide --- stereotactic body radiation therapy --- immunohistochemistry --- gastric carcinoma --- liver transplant --- CAM invasion assay --- intragraft gene expression profiles --- molecular profiling --- targeted therapy --- neurotensin --- intestinal disorder --- ramucirumab --- next-generation sequencing --- colorectal carcinoma --- tumor progenitor --- circulating tumor cells --- gastrointestinal malignancies --- bombesin --- trastuzumab --- somatostatin --- zebrafish --- G protein–coupled receptors --- G protein-coupled receptors
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PacBio’s single-molecule real-time (SMRT) sequencing technology offers important advantages over the short-read DNA sequencing technologies that currently dominate the market. This includes exceptionally long read lengths (20 kb or more), unparalleled consensus accuracy, and the ability to sequence native, non-amplified DNA molecules. From fungi to insects to humans, long reads are now used to create highly accurate reference genomes by de novo assembly of genomic DNA and to obtain a comprehensive view of transcriptomes through the sequencing of full-length cDNAs. Besides reducing biases, sequencing native DNA also permits the direct measurement of DNA base modifications. Therefore, SMRT sequencing has become an attractive technology in many fields, such as agriculture, basic science, and medical research. The boundaries of SMRT sequencing are continuously being pushed by developments in bioinformatics and sample preparation. This book contains a collection of articles showcasing the latest developments and the breadth of applications enabled by SMRT sequencing technology.
n/a --- Cladobotryum protrusum --- allele-specific analysis --- low-input DNA --- full length RNAseq --- de novo genome assembly --- de novo assembly --- human reference genome --- Tricoplusia ni --- PacBio single molecule real-time sequencing --- secondary metabolite --- protein isoforms --- bone marrow cell subpopulations --- DNA methylation --- mycoparasite --- human whole-genome sequencing --- GRCh38 --- SMRT sequencing --- cytochrome P450 enzyme (CYP) --- mRNA isoforms --- next generation sequencing --- cobweb disease --- Swedish population --- mosquito --- long-read SMRT sequencing --- whole genome sequencing --- terpenoid --- insect genome --- optical mapping --- Gloeostereum incarnatum --- population sequencing --- statistical methods --- gene expression --- single molecule real-time sequencing --- PacBio
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