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Compensating for cytotoxicity in the multicellular organism by a certain level of cellular proliferation is the primary aim of homeostasis. In addition, the loss of cellular proliferation control (tumorigenesis) is at least as important as cytotoxicity, however, it is a contrasting trauma. With the disruption of the delicate balance between cytotoxicity and proliferation, confrontation with cancer can inevitably occur. This book presents important information pertaining to the molecular control of the mechanisms of cytotoxicity and cellular proliferation as they relate to cancer. It is designed for students and researchers studying cytotoxicity and its control.
Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Toxicology and Pharmaceutical Science --- Medical Toxicology --- Health Sciences
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Over 400 years ago, Swiss alchemist and physician Paracelsus (1493-1541) cited: ""All substances are poisons; there is none that is not a poison. The right dose differentiates a poison from a remedy."" This is often condensed to: ""The dose makes the poison."" So, why are we overtly anxious about intoxications?In fact, poisons became a global problem with the industrial revolution. Pesticides, asbestos, occupational chemicals, air pollution, and heavy metal toxicity maintain high priority worldwide, especially in developing countries. Children between 0 and 5 years old are the most vulnerable to both acute and chronic poisonings, while older adults suffer from the chronic effects of chemicals. This book aims to raise awareness about the challenges of poisons, to help clinicians understand current issues in toxicology.
Poisons --- Risk assessment. --- Chemicals --- Poisonous chemicals --- Poisonous substances --- Toxic chemicals --- Toxic substances --- Toxicants --- Toxics --- Bioactive compounds --- Hazardous substances --- Toxicology --- Toxicology and Pharmaceutical Science --- Pharmacology --- Medical Toxicology --- Health Sciences
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