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Book
Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile
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ISBN: 3039213164 3039213156 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile.


Book
Mechanism Design for Robotics
Authors: ---
ISBN: 3039210599 3039210580 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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MEDER 2018, the IFToMM International Symposium on Mechanism Design for Robotics, was the fourth event in a series that was started in 2010 as a specific conference activity on mechanisms for robots. The aim of the MEDER Symposium is to bring researchers, industry professionals, and students together from a broad range of disciplines dealing with mechanisms for robots, in an intimate, collegial, and stimulating environment. In the 2018 MEDER event, we received significant attention regarding this initiative, as can be seen by the fact that the Proceedings contain contributions by authors from all around the world.The Proceedings of the MEDER 2018 Symposium have been published within the Springer book series on MMS, and the book contains 52 papers that have been selected after review for oral presentation. These papers cover several aspects of the wide field of robotics dealing with mechanism aspects in theory, design, numerical evaluations, and applications.This Special Issue of Robotics (https://www.mdpi.com/journal/robotics/special_issues/MDR) has been obtained as a result of a second review process and selection, but all the papers that have been accepted for MEDER 2018 are of very good quality with interesting contents that are suitable for journal publication, and the selection process has been difficult.

Keywords

n/a --- robot control --- cylindrical --- V2SOM --- 3-UPU parallel mechanism --- McKibben muscle --- compliance control --- gait planning --- grasp stability --- robot singularity --- safety mechanism --- robot --- exercising device --- hexapod walking robot --- inadvertent braking --- energy efficiency --- robotic cell --- humanoid robots --- collaborative robot --- robot wrists --- humanoid robotic hands --- stability --- cable-driven robots --- image processing --- fail-safe operation --- VSA --- graphical user interface --- computer-aided design --- robotic legs --- human-robot-interaction --- shape changing --- painting robot --- shape memory alloy --- velocity control --- underactuated fingers --- safe physical human–robot interaction (pHRI) --- human-machine interaction --- compliant mechanism --- iCub --- robot-assisted Doppler sonography --- pHRI --- spherical parallel mechanism --- mobile manipulation --- economic locomotion --- haptic glove --- learning by demonstration --- robot kinematics --- variable stiffness actuator (VSA) --- workspace analysis --- singularity analysis --- collaborative robots --- parallel mechanisms --- rolling --- SMA actuator --- elliptical --- cable-driven parallel robots --- non-photorealistic rendering --- redundancy --- kinematic redundancy --- variable stiffness actuator --- trajectory planning --- kinematics --- pneumatic artificial muscle --- artistic rendering --- force reflection --- safe physical human–robot interaction --- orientational mechanisms --- teleoperation --- actuation burden --- cobot --- hand exoskeleton --- safe physical human-robot interaction (pHRI) --- safe physical human-robot interaction

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