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The title of the book ""The Universe of Escherichia coli"" aims to present and emphasize the huge diversity of this bacterial species and our efforts to prevent the E. coli infections. As it is part of the gut microbiota, E. coli is a well-known commensal species, and probiotic E. coli strains are successfully used for improving host's health. Also many ""workhorse"" E. coli strain exist that are employed in laboratory and biotechnology settings. But certain E. coli strains can cause intestinal and also extraintestinal infections at many anatomical sites. Therefore many efforts are undertaken to prevent E. coli infections, among them food safety, vaccines, but also new antimicrobial agents are searched for.
Escherichia coli. --- E. coli (Bacterium) --- Escherichia --- Life Sciences --- Microbiology --- Genetics and Molecular Biology --- Biochemistry --- Bacteriology
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Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.
hematopoietic cells --- DEPArray --- n/a --- neuroblastoma --- liver steatosis --- MAPK phosphatase --- DUSP-4 --- granule neurons --- neuronal differentiation --- DUSP10 --- cytokines --- MAPKs --- single cell analysis --- macrophage --- asthma --- E. coli infection --- MAPK --- Cpp1 --- nucleotide receptors --- atypical DUSP --- RSV --- Pmp1 --- cannabinoids --- astrocytes --- sepsis --- influenza --- signaling --- triple-negative breast cancer (TNBC) --- differentiation --- HDAC6 (histone deacetylase isoform 6) --- atypical dual-specificity phosphatases --- microtubules --- respiratory viruses --- MK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein) --- dual-specificity phosphatase --- Msg5 --- TLR signaling --- mitogen-activated protein kinase --- fungal MKPs --- macrophages --- MAP Kinase Phosphatase-2 --- inflammation --- Sdp1 --- circulating tumor cells (CTCs) --- MAP kinases --- MAP kinase phosphatases --- P2X7 --- proliferation --- BDNF --- P2Y13 --- T cell --- hypertriglyceridemia --- integrated omics analysis --- post-translational modification --- rhinovirus --- protein stability --- ubiquitination --- dual-specificity phosphatases --- Mkp-1 --- cancer --- brain metastasis --- HER2 --- COPD --- pseudophosphatase
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Microfluidics-based devices play an important role in creating realistic microenvironments in which cell cultures can thrive. They can, for example, be used to monitor drug toxicity and perform medical diagnostics, and be in a static-, perfusion- or droplet-based device. They can also be used to study cell-cell, cell-matrix or cell-surface interactions. Cells can be either single cells, 3D cell cultures or co-cultures. Other organisms could include bacteria, zebra fish embryo, C. elegans, to name a few.
n/a --- screening --- microfluidic device --- cell homogenous dispersion structure --- RNA --- biomedical engineering --- neural networks --- single-cell mechanics --- on-chip cell incubator --- cell growth --- embryogenesis --- cancer stem cell --- intracellular proteins --- simultaneous multiple chamber observation --- instrumentation --- fnRBC --- cancer metastasis --- Wheatstone bridge --- capillary --- single-cell manipulation --- adherent cells --- nucleic acid --- micropipette aspiration --- sample preparation --- unsupervised learning --- cell motility --- capture efficiency --- bacterial concentration --- cbNIPD --- microfabrication --- drug resistance --- variational inference --- microfluidics --- periodic hydrostatic pressure --- paracrine signaling --- periodic pressure --- capacitively coupled contactless conductivity detection (C4D) --- bioMEMS --- microfluidic flow cytometry --- particle/cell imaging --- co-culture --- cells-in-gels-in-paper --- laminar flows --- E. coli --- printed-circuit-board (PCB) --- pneumatic microvalve --- time-lapse observation --- nanostructure --- 3D particle focusing --- target cell-specific binding molecules --- absolute quantification --- DNA --- zebrafish embryo --- microscopy --- 3D printing --- 3D flow focusing --- single-cell analysis
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The quality of drinking water is paramount for public health. Despite important improvements in the last decades, access to safe drinking water is not universal. The World Health Organization estimates that almost 10% of the population in the world do not have access to improved drinking water sources. Among other diseases, waterborne infections cause diarrhea, which kills nearly one million people every year, mostly children under 5 years of age. On the other hand, chemical pollution is a concern in high-income countries and an increasing problem in low- and middle-income countries. Exposure to chemicals in drinking water may lead to a range of chronic non-communicable diseases (e.g., cancer, cardiovascular disease), adverse reproductive outcomes, and effects on children’s health (e.g., neurodevelopment), among other health effects. Although drinking water quality is regulated and monitored in many countries, increasing knowledge leads to the need for reviewing standards and guidelines on a nearly permanent basis, both for regulated and newly identified contaminants. Drinking water standards are mostly based on animal toxicity data, and more robust epidemiologic studies with accurate exposure assessment are needed. The current risk assessment paradigm dealing mostly with one-by-one chemicals dismisses the potential synergisms or interactions from exposures to mixtures of contaminants, particularly at the low-exposure range. Thus, evidence is needed on exposure and health effects of mixtures of contaminants in drinking water. Finally, water stress and water quality problems are expected to increase in the coming years due to climate change and increasing water demand by population growth, and new evidence is needed to design appropriate adaptation policies.This Special Issue of International Journal of Environmental Research and Public Health (IJERPH) focuses on the current state of knowledge on the links between drinking water quality and human health.
risk assessment --- time series study --- risk context --- ammonia --- fluoride --- exposure assessment --- water safety plan --- HWTS implementation --- human health --- simulation study --- drinking water guidance --- chlorination by-product --- adverse reproductive outcomes --- spatial variations --- THMs --- zinc --- radioactivity --- thyroid disease --- risk management --- infants --- water contamination --- infant health --- small for gestational age --- drinking water quality --- methemoglobinemia --- magnesium --- monitoring --- effect measure modification --- nitrite --- health-based guideline --- environmental exposure --- organic matter --- Maryland --- tap water --- impact assessment --- turbidity --- chronic kidney disease --- fever --- diarrhoeal disease --- rural water resources --- drinking water --- acute gastroenteritis --- Nigeria --- E. coli --- pharmacokinetic modeling --- chemical risk assessment --- uncertainty factors --- community water system --- groundwater --- dental health --- inorganic manganese --- atrazine --- duration extrapolation --- health insurance data --- space–time detection --- seasonality --- fecal coliforms --- water safety plans --- preterm birth --- dissolved oxygen --- gravity-fed piped water scheme --- urban area --- cough --- water operation data --- screening method --- endogenous nitrosation --- infant exposure --- sanitary inspection --- waterborne disease outbreak --- N-nitroso compounds --- end-stage renal disease --- arsenic --- diarrhea --- sodium --- private wells --- animal feeding operation --- endocrine disruptor --- Vibrio pathogens --- LTD --- disinfection by-product --- chemical oxygen demand --- potassium --- biomonitoring --- nitrate --- annual effective dose --- sub-Saharan Africa --- France --- carcinogenic --- public health --- enterococci --- calcium --- water and sanitation --- pharmaceuticals --- environment --- drinking water distribution systems --- water contaminants --- Asia-Pacific region --- Denmark --- trihalomethanes --- risk --- cancer --- low birth weight --- drug labels --- risk assessment --- time series study --- risk context --- ammonia --- fluoride --- exposure assessment --- water safety plan --- HWTS implementation --- human health --- simulation study --- drinking water guidance --- chlorination by-product --- adverse reproductive outcomes --- spatial variations --- THMs --- zinc --- radioactivity --- thyroid disease --- risk management --- infants --- water contamination --- infant health --- small for gestational age --- drinking water quality --- methemoglobinemia --- magnesium --- monitoring --- effect measure modification --- nitrite --- health-based guideline --- environmental exposure --- organic matter --- Maryland --- tap water --- impact assessment --- turbidity --- chronic kidney disease --- fever --- diarrhoeal disease --- rural water resources --- drinking water --- acute gastroenteritis --- Nigeria --- E. coli --- pharmacokinetic modeling --- chemical risk assessment --- uncertainty factors --- community water system --- groundwater --- dental health --- inorganic manganese --- atrazine --- duration extrapolation --- health insurance data --- space–time detection --- seasonality --- fecal coliforms --- water safety plans --- preterm birth --- dissolved oxygen --- gravity-fed piped water scheme --- urban area --- cough --- water operation data --- screening method --- endogenous nitrosation --- infant exposure --- sanitary inspection --- waterborne disease outbreak --- N-nitroso compounds --- end-stage renal disease --- arsenic --- diarrhea --- sodium --- private wells --- animal feeding operation --- endocrine disruptor --- Vibrio pathogens --- LTD --- disinfection by-product --- chemical oxygen demand --- potassium --- biomonitoring --- nitrate --- annual effective dose --- sub-Saharan Africa --- France --- carcinogenic --- public health --- enterococci --- calcium --- water and sanitation --- pharmaceuticals --- environment --- drinking water distribution systems --- water contaminants --- Asia-Pacific region --- Denmark --- trihalomethanes --- risk --- cancer --- low birth weight --- drug labels
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The quality of drinking water is paramount for public health. Despite important improvements in the last decades, access to safe drinking water is not universal. The World Health Organization estimates that almost 10% of the population in the world do not have access to improved drinking water sources. Among other diseases, waterborne infections cause diarrhea, which kills nearly one million people every year, mostly children under 5 years of age. On the other hand, chemical pollution is a concern in high-income countries and an increasing problem in low- and middle-income countries. Exposure to chemicals in drinking water may lead to a range of chronic non-communicable diseases (e.g., cancer, cardiovascular disease), adverse reproductive outcomes, and effects on children’s health (e.g., neurodevelopment), among other health effects. Although drinking water quality is regulated and monitored in many countries, increasing knowledge leads to the need for reviewing standards and guidelines on a nearly permanent basis, both for regulated and newly identified contaminants. Drinking water standards are mostly based on animal toxicity data, and more robust epidemiologic studies with accurate exposure assessment are needed. The current risk assessment paradigm dealing mostly with one-by-one chemicals dismisses the potential synergisms or interactions from exposures to mixtures of contaminants, particularly at the low-exposure range. Thus, evidence is needed on exposure and health effects of mixtures of contaminants in drinking water. Finally, water stress and water quality problems are expected to increase in the coming years due to climate change and increasing water demand by population growth, and new evidence is needed to design appropriate adaptation policies.This Special Issue of International Journal of Environmental Research and Public Health (IJERPH) focuses on the current state of knowledge on the links between drinking water quality and human health.
risk assessment --- time series study --- risk context --- ammonia --- fluoride --- exposure assessment --- water safety plan --- HWTS implementation --- human health --- simulation study --- drinking water guidance --- chlorination by-product --- adverse reproductive outcomes --- spatial variations --- THMs --- zinc --- radioactivity --- thyroid disease --- risk management --- infants --- water contamination --- infant health --- small for gestational age --- drinking water quality --- methemoglobinemia --- magnesium --- monitoring --- effect measure modification --- nitrite --- health-based guideline --- environmental exposure --- organic matter --- Maryland --- tap water --- impact assessment --- turbidity --- chronic kidney disease --- fever --- diarrhoeal disease --- rural water resources --- drinking water --- acute gastroenteritis --- Nigeria --- E. coli --- pharmacokinetic modeling --- chemical risk assessment --- uncertainty factors --- community water system --- groundwater --- dental health --- inorganic manganese --- atrazine --- duration extrapolation --- health insurance data --- space–time detection --- seasonality --- fecal coliforms --- water safety plans --- preterm birth --- dissolved oxygen --- gravity-fed piped water scheme --- urban area --- cough --- water operation data --- screening method --- endogenous nitrosation --- infant exposure --- sanitary inspection --- waterborne disease outbreak --- N-nitroso compounds --- end-stage renal disease --- arsenic --- diarrhea --- sodium --- private wells --- animal feeding operation --- endocrine disruptor --- Vibrio pathogens --- LTD --- disinfection by-product --- chemical oxygen demand --- potassium --- biomonitoring --- nitrate --- annual effective dose --- sub-Saharan Africa --- France --- carcinogenic --- public health --- enterococci --- calcium --- water and sanitation --- pharmaceuticals --- environment --- drinking water distribution systems --- water contaminants --- Asia-Pacific region --- Denmark --- trihalomethanes --- risk --- cancer --- low birth weight --- drug labels
Choose an application
The quality of drinking water is paramount for public health. Despite important improvements in the last decades, access to safe drinking water is not universal. The World Health Organization estimates that almost 10% of the population in the world do not have access to improved drinking water sources. Among other diseases, waterborne infections cause diarrhea, which kills nearly one million people every year, mostly children under 5 years of age. On the other hand, chemical pollution is a concern in high-income countries and an increasing problem in low- and middle-income countries. Exposure to chemicals in drinking water may lead to a range of chronic non-communicable diseases (e.g., cancer, cardiovascular disease), adverse reproductive outcomes, and effects on children’s health (e.g., neurodevelopment), among other health effects. Although drinking water quality is regulated and monitored in many countries, increasing knowledge leads to the need for reviewing standards and guidelines on a nearly permanent basis, both for regulated and newly identified contaminants. Drinking water standards are mostly based on animal toxicity data, and more robust epidemiologic studies with accurate exposure assessment are needed. The current risk assessment paradigm dealing mostly with one-by-one chemicals dismisses the potential synergisms or interactions from exposures to mixtures of contaminants, particularly at the low-exposure range. Thus, evidence is needed on exposure and health effects of mixtures of contaminants in drinking water. Finally, water stress and water quality problems are expected to increase in the coming years due to climate change and increasing water demand by population growth, and new evidence is needed to design appropriate adaptation policies.This Special Issue of International Journal of Environmental Research and Public Health (IJERPH) focuses on the current state of knowledge on the links between drinking water quality and human health.
risk assessment --- time series study --- risk context --- ammonia --- fluoride --- exposure assessment --- water safety plan --- HWTS implementation --- human health --- simulation study --- drinking water guidance --- chlorination by-product --- adverse reproductive outcomes --- spatial variations --- THMs --- zinc --- radioactivity --- thyroid disease --- risk management --- infants --- water contamination --- infant health --- small for gestational age --- drinking water quality --- methemoglobinemia --- magnesium --- monitoring --- effect measure modification --- nitrite --- health-based guideline --- environmental exposure --- organic matter --- Maryland --- tap water --- impact assessment --- turbidity --- chronic kidney disease --- fever --- diarrhoeal disease --- rural water resources --- drinking water --- acute gastroenteritis --- Nigeria --- E. coli --- pharmacokinetic modeling --- chemical risk assessment --- uncertainty factors --- community water system --- groundwater --- dental health --- inorganic manganese --- atrazine --- duration extrapolation --- health insurance data --- space–time detection --- seasonality --- fecal coliforms --- water safety plans --- preterm birth --- dissolved oxygen --- gravity-fed piped water scheme --- urban area --- cough --- water operation data --- screening method --- endogenous nitrosation --- infant exposure --- sanitary inspection --- waterborne disease outbreak --- N-nitroso compounds --- end-stage renal disease --- arsenic --- diarrhea --- sodium --- private wells --- animal feeding operation --- endocrine disruptor --- Vibrio pathogens --- LTD --- disinfection by-product --- chemical oxygen demand --- potassium --- biomonitoring --- nitrate --- annual effective dose --- sub-Saharan Africa --- France --- carcinogenic --- public health --- enterococci --- calcium --- water and sanitation --- pharmaceuticals --- environment --- drinking water distribution systems --- water contaminants --- Asia-Pacific region --- Denmark --- trihalomethanes --- risk --- cancer --- low birth weight --- drug labels
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