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Coeliac Disease (CD) affects at least 1% of the population. "Classical" CD refers to gastrointestinal presentations with anaemia and gastrointestinal symptoms. CD can, however, present with extraintestinal manifestations, the commonest of which are dermatitis herpetiformis and neurological presentations (e.g., ataxia, neuropathy, encephalopathy). Recognition and research into the pathophysiology of such manifestations is likely to enhance our understanding of this complex autoimmune disorder.

Celiac disease.

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Coeliac Disease (CD) affects at least 1% of the population. "Classical" CD refers to gastrointestinal presentations with anaemia and gastrointestinal symptoms. CD can, however, present with extraintestinal manifestations, the commonest of which are dermatitis herpetiformis and neurological presentations (e.g., ataxia, neuropathy, encephalopathy). Recognition and research into the pathophysiology of such manifestations is likely to enhance our understanding of this complex autoimmune disorder.

Celiac disease.

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In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD. For these reasons, research on the GFD and its clinical use and biological effects is urgently needed.

Gluten-free diet. --- Celiac disease --- Diet therapy

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The goal of this Special Issue, "Probiotics and Prebiotics in Pediatrics", is to focus on the importance of pediatric nutrition with probiotics and prebiotics to improve gastrointestinal health in newborn, infants, and children.Specifically, the aim is to clarify if probiotics and prebiotics can influence gut microbiota composition and host-interaction favoring human health and preventing diseases.This new information will provide health care professionals with a widespread, clear and update evidence on probiotics and prebiotics and intestinal gut microbiota in pediatric care.

non-IgE mediated allergy --- n/a --- randomized controlled trials --- infant --- “Probiotics”[Mesh] --- children --- safety --- therapeutic microbiology --- zinc --- prevention --- Lactobacillus --- cow’s milk protein --- constipation --- hepcidin --- infants --- Bifidobacterium --- Bifidobacterium breve --- allergy --- asthma --- functional abdominal pain disorders --- probiotic strain --- formula feeding --- probiotic --- nutritional programming --- 2?-fucosyllactose --- “Pregnancy”[Mesh] --- colic --- iron absorption --- bifidobacteria --- Newborn”[Mesh] --- breast feeding --- neonatal --- diversity --- acute diarrhea --- celiac disease --- human milk oligosaccharide --- acute gastroenteritis --- human milk oligosaccharides --- tolerance acquisition --- iron deficiency anemia --- infantile colic --- Lacto-N-neotetraose --- gluten free diet --- oligosaccharides --- preterm --- preterm infant --- microbial programming --- paediatrics --- Lactobacillus reuteri --- functional constipation --- protein hydrolyzed formulas --- oral rehydration solution --- gluten-free diet --- infant formula --- prebiotic --- Childhood Asthma Control Test --- microbiome --- intestinal transit time --- prebiotics --- sepsis --- probiotics --- microbiota --- “Infant --- lactobacilli --- human milk --- functional gastrointestinal disorders --- inulin --- fecal microbiota --- Bacillus clausii --- peak expiratory flow rate --- breast milk --- immunoglobulin E --- efficacy --- intestinal microbiota --- necrotizing enterocolitis --- pediatrics --- growth --- "Probiotics"[Mesh] --- cow's milk protein --- "Pregnancy"[Mesh] --- Newborn"[Mesh] --- "Infant