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La 4e de couverture indique : "Cet ouvrage couvre les différents aspects de la structure des protéines : leur composition chimique, l'établissement de leur structure, les différents niveaux de leur organisation, les aspects énergétiques de leur stabilité, leur dynamique moléculaire et la prédiction théorique de leur structure, prenant en compte les résultats substantiels et significatifs obtenus au cours des dernières années. Le premier chapitre concerne la chimie de leurs constituants de base, les acides aminés, connaissance qui est précieuse pour les chimistes des protéines et les enzymologistes mais dont les données sont dispersées dans la littérature. Pour la première fois dans ce type d'ouvrage un chapitre entier est consacré aux protéines membranaires, dans la connaissance desquelles des progrès considérables ont été faits au cours des dernières années. Suit une description des mécanismes très élaborés de l'insertion de ces protéines dans les membranes biologiques. Un chapitre est consacré à la dynamique conformationnelle de ces macromolécules, qui joue un rôle fondamental dans leur propriétés biologiques. Les logiciels qui permettent de prédire la structure des protéines sur la base de leur composition en acides aminés sont également présentés. D'un point de vue pédagogique, certains chapitres comportent un exposé plus ou moins bref de l'histoire de certaines découvertes importantes ou la logique d'évolution de concepts majeurs ou de techniques expérimentales de haut niveau."

Proteins --- Protein Conformation. --- Protéines --- Conformation des protéines. --- Structure --- Structure. --- Protéines

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"Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured. Written and edited by leading scientists in the field, this book explores groundbreaking areas such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs. Intrinsically Disordered Proteins provides students and researchers in biochemistry, molecular biology, and applied microbiology with a comprehensive and updated discussion of the complex dynamics of IDPs and IDRs."--

Proteins --- Structure. --- Intrinsically Disordered Proteins --- Carrier Proteins. --- Protein Conformation --- physiology. --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Folding --- Binding Protein --- Binding Proteins --- Transport Proteins --- Protein, Binding --- Proteins, Binding --- Proteins, Carrier --- Proteins, Transport --- Protein Binding --- Receptors, Transferrin --- Carrier Protein --- Transport Protein --- Protein, Carrier --- Protein, Transport

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This textbook teaches bioengineers critical concepts about protein three dimensional structures, how proteins fold, and how the folding affects the functioning of the protein. Protein folding has profound effects on the discovery of biopharmaceutical drugs (especially the transport of immunological compounds to their site of action) as well as on tissue engineering. Dr. Dods covers topics in easily understood terms through the use of glossaries heading each chapter and footnotes and summaries at the end of each chapter. The chapters cover disordered proteins and large sequences of disorder that exists within proteins, secondary structure (α-helix and β-pleated structure), tertiary and quaternary structure, post-translational changes, proteopathies, bioengineering approaches used to study protein folding, and computer software for protein folding. For each of these topics the elements of biomolecular imaging, cellular and tissue engineering, and health care systems engineering are built. Molecular engineering concepts such as site-directed mutagenesis are addressed. For reinforcement of the concepts presented in this text, activities and problems (Queries) are included in the chapter. Introduces the folding of proteins as an aspect of bioscience engineering in simple, understandable language Supports readers’ ingestion of more-challenging ideas with glossaries, footnotes, summaries , and color illustrations, Reinforces reader understanding with additional materials, and end-of-chapter problems Discusses protein structure, folding and the bioengineering of cells, tissues and organs, pharmaceutical delivery systems using hydrogels, nanospheres, liposomes, and amino clay.

Biomaterials. --- Biomedical engineering. --- Regenerative medicine. --- Tissue engineering. --- Bioorganic chemistry. --- Biomedical Engineering/Biotechnology. --- Biomedical Engineering and Bioengineering. --- Regenerative Medicine/Tissue Engineering. --- Bioorganic Chemistry. --- Bio-organic chemistry --- Biological organic chemistry --- Biochemistry --- Chemistry, Organic --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Medicine --- Regeneration (Biology) --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Biocompatible materials --- Biomaterials --- Medical materials --- Materials --- Biocompatibility --- Prosthesis --- Bioengineering. --- Protein folding. --- Folding of proteins --- Proteins --- Biological engineering --- Life science engineering --- Biology --- Synthetic biology --- Folding --- Conformation --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials)

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This book, as a collection of 17 research articles, provides a selection of the most recent advances in the synthesis, characterization, and applications of environmentally friendly and biodegradable biopolymer composites and nanocomposites. Recently, the demand has been growing for a clean and pollution-free environment and an evident target regarding the minimization of fossil fuel usage. Therefore, much attention has been focused on research to replace petroleum-based commodity plastics by biodegradable materials arising from biological and renewable resources. Biopolymers—polymers produced from natural sources either chemically from a biological material or biosynthesized by living organisms—are suitable alternatives for addressing these issues due to their outstanding properties, including good barrier performance, biodegradation ability, and low weight. However, they generally possess poor mechanical properties, a short fatigue life, low chemical resistance, poor long-term durability, and limited processing capability. In order to overcome these deficiencies, biopolymers can be reinforced with fillers or nanofillers (with at least one of their dimensions in the nanometer range). Bionanocomposites are advantageous for a wide range of applications, such as in medicine, pharmaceutics, cosmetics, food packaging, agriculture, forestry, electronics, transport, construction, and many more.

biodegradable films --- chitosan --- natural rubber --- n/a --- toughening --- elastomer --- deoxycholic acid --- cellulose fibers --- amphiphilic polymer --- cross-link density --- antioxidant activity --- nanocomposites --- silk fibroin --- impact properties --- conductivity --- antimicrobial agents --- Py-GC/MS --- Poly(propylene carbonate) --- biodisintegration --- peptide-cellulose conformation --- nanocomposite --- alginate films --- toughness --- protease sensor --- physical and mechanical properties --- biocomposites --- nanocellulose --- thermal decomposition kinetics --- potato protein --- micelles --- nanofibers --- mechanical properties --- active packaging materials --- cellulose --- structural profile --- glycol chitosan --- glass transition --- essential oils --- compatibility --- plasticized starch --- natural fibers --- biopolyester --- human neutrophil elastase --- biodegradation --- bio-composites --- fiber/matrix adhesion --- ?-tocopherol succinate --- MgO whiskers --- carbon nanotubes --- PLLA --- electrospinning --- chitin nanofibrils --- FTIR --- biopolymers composites --- DMA --- wheat gluten --- water uptake --- folic acid --- polycarbonate --- aerogel --- surfactant --- paclitaxel --- chemical pre-treatment --- biomass --- thermoplastic polyurethane --- poly(3-hydroxybutyrate-3-hydroxyvalerate) --- stress-strain --- polyfunctional monomers --- bio-based polymers --- tensile properties --- compatibilizer --- TG/FTIR --- PVA --- in vitro degradation --- poly(lactic acid) --- heat deflection temperature