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Phototoxicity is defined as a toxic response is elicited by topically or systemically administered photoreactive chemicals after the exposure of the body to environmental light. Several classes of photoreactive chemicals could cause phototoxic reactions when activated by light at otherwise non-toxic doses. Phototoxicity can be categorized as photoirritation, photoallergy, and photogenotoxicity. The purpose of this test is to measure the phototoxicity of a chemical. The main event in any phototoxic reaction is the absorption of photons of a wavelength that induces the excitation of the chromophore. Excitation energy is often transferred to oxygen molecules, followed by the generation of ROS (reactive Oxygen Species). Measurements are performed using a spectrometer. The determination of the ROS generation from irradiated chemicals with simulated sunlight is indicative of phototoxic potential.

Active oxygen --- Photochemistry. --- Physiological effect.

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Phototoxicity is defined as a toxic response is elicited by topically or systemically administered photoreactive chemicals after the exposure of the body to environmental light. Several classes of photoreactive chemicals could cause phototoxic reactions when activated by light at otherwise non-toxic doses. Phototoxicity can be categorized as photoirritation, photoallergy, and photogenotoxicity. The purpose of this test is to measure the phototoxicity of a chemical. The main event in any phototoxic reaction is the absorption of photons of a wavelength that induces the excitation of the chromophore. Excitation energy is often transferred to oxygen molecules, followed by the generation of ROS (reactive Oxygen Species). Measurements are performed using a spectrometer. The determination of the ROS generation from irradiated chemicals with simulated sunlight is indicative of phototoxic potential.

Active oxygen --- Photochemistry. --- Physiological effect.

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La phototoxicité est définie comme une réaction toxique causée par des produits chimiques photoréactifs administrés par voie topique ou systémique, après exposition du corps à la lumière ambiante. Plusieurs classes de produits chimiques photoréactifs peuvent provoquer des réactions phototoxiques lorsqu'ils sont activés par la lumière, à des doses ne présentant pas d'autres effets toxiques. La phototoxicité peut être subdivisée en photo-irritation, photoallergie et photogénotoxicité. Le but de cet essai est de mesurer la phototoxicité d'un produit chimique. L'événement principal dans toute réaction phototoxique est l'absorption des photons d'une longueur d'onde qui induit l'excitation du chromophore. L'énergie d'excitation est souvent transférée aux molécules d'oxygène, suivies par la génération de ROS (Reactive Oxygene Species). Les mesures sont effectuées à l'aide d'un spectromètre. La détermination de la génération ROS à partir de produits chimiques irradiés avec la lumière du soleil simulée est révélateur d'un potentiel phototoxique.

Active oxygen --- Photochemistry. --- Toxicity testing. --- Physiological effect.

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This book presents the fundamentals and the state of the art of the photophysics of molecular oxygen. The author examines optical transitions between the lowest-lying electronic states in molecular oxygen and how these transitions respond to perturbation, either from an organic molecule or from the plasmon field of a metal nanoparticle. We live on a planet filled with light and oxygen. The interaction between these two components forms the basis of excited state chemistry spanning the fields of synthetic organic chemistry, materials chemistry, molecular biology, and photodynamic treatment of cancer. Still, the fundamental ways in which oxygen is affected by light is an active subject of research and is continually being developed and rationalized. In this book, readers will learn that singlet oxygen, the excited state of oxygen that exhibits unique chemical reactivity, can be selectively made via direct optical excitation of oxygen in a sensitizer-free system. Readers will also discover that this approach can perturb living cells differently depending on the singlet oxygen “dose”.

Active oxygen. --- Molecules. --- Chemistry, Physical organic. --- Nanochemistry. --- Physical Chemistry. --- Atomic/Molecular Structure and Spectra. --- Biological and Medical Physics, Biophysics. --- Nanoscale chemistry --- Chemistry, Analytic --- Nanoscience --- Chemistry, Physical organic --- Chemistry, Organic --- Chemistry, Physical and theoretical --- Analytical chemistry --- Physical chemistry. --- Atomic structure  . --- Molecular structure . --- Biophysics. --- Biological physics. --- Biological physics --- Biology --- Medical sciences --- Physics --- Structure, Molecular --- Chemical structure --- Structural bioinformatics --- Structure, Atomic --- Atomic theory --- Chemistry, Theoretical --- Physical chemistry --- Theoretical chemistry --- Chemistry

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This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Cell biology. --- Cardiology. --- Biochemistry. --- Biomedical engineering. --- Health promotion. --- Cell physiology. --- Cell Biology. --- Biochemistry, general. --- Biomedical Engineering/Biotechnology. --- Health Promotion and Disease Prevention. --- Cell Physiology. --- Cell function --- Cytology --- Physiology --- Health promotion programs --- Health promotion services --- Promotion of health --- Wellness programs --- Preventive health services --- Health education --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Heart --- Internal medicine --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Diseases --- Active oxygen. --- Molecular aspects. --- Oxygen radicals --- Reactive oxygen --- Singlet oxygen --- Superperoxide anion --- Free radicals (Chemistry) --- Ionization of gases --- Oxygen --- Estrès oxidatiu --- Malalties del cor