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El presente libro Patógenos de importancia clínica: Inves­tigaciones Recientes en el Valle del Cauca nace como una iniciativa para socializar los resultados obtenidos en los tra­bajos de investigación más recientes de los miembros del Grupo de Investigación en genética, fisiología y metabolis­mo –GEFIME– de la Universidad Santiago de Cali. Estas investigaciones involucran patógenos que son importantes agentes causales de infecciones y de alto impacto en la salud pública en la ciudad de Cali y en el Valle del Cauca.Este libro consta de cinco capítulos con trabajos de investiga­ción en bacterias resistentes a los antibióticos como Staphylo­coccus aureus y Mycobacterium tuberculosis y su comporta­miento epidemiológico en ambientes intrahospitalarios y en poblaciones, respectivamente. En el Capítulo 3 se presenta un estudio epidemiológico que establece la presencia del virus del papiloma humano (VPH) en mucosa oral y su relación con el desarrollando cáncer oral y en el Capítulo 4 se presenta una investigación realizada con moléculas efectoras (alarmona pp­Gpp y la proteína DksA) de Salmonella enterica serovar Typhi­murium y su influencia en la patogenicidad y la formación de biopelículas in-vitro.

Biochemistry --- pathogens, and health. --- Colombia --- pathogens, and health.

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Foodborne illness resulting from food production animals is a global health concern, and the Centers for Disease Control estimate that one in six Americans will become sick with a foodborne illness each year. Of course there are numerous causes for these outbreaks, but contamination from a food production animal is certainly one source. Understanding the host-pathogen interaction and how foodborne bacterial pathogens establish a persistent infection and evade host immune responses will be pivotal in reducing the instance of foodborne illness traced back to a food production animal source. In this volume, we bring together original research and review articles covering some of the key issues surrounding the mechanisms of persistence, survival, and transmission of bacterial foodborne pathogens in production animals. The research focused on poultry and specifically addressed antibiotic resistance, Salmonella colonization, pathogen reduction strategies using pre- or probiotics, pathogen evasion, and post-harvest intervention and pathogen testing. The following 11 articles are fine examples of the multidisciplinary approaches that will be required to address and understand the complex interplay between food safety and animal production.

Persistence --- Salmonella --- Poultry --- Transmission --- Bacterial Foodborne Pathogens --- Survival --- Production Animals

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Foodborne illness resulting from food production animals is a global health concern, and the Centers for Disease Control estimate that one in six Americans will become sick with a foodborne illness each year. Of course there are numerous causes for these outbreaks, but contamination from a food production animal is certainly one source. Understanding the host-pathogen interaction and how foodborne bacterial pathogens establish a persistent infection and evade host immune responses will be pivotal in reducing the instance of foodborne illness traced back to a food production animal source. In this volume, we bring together original research and review articles covering some of the key issues surrounding the mechanisms of persistence, survival, and transmission of bacterial foodborne pathogens in production animals. The research focused on poultry and specifically addressed antibiotic resistance, Salmonella colonization, pathogen reduction strategies using pre- or probiotics, pathogen evasion, and post-harvest intervention and pathogen testing. The following 11 articles are fine examples of the multidisciplinary approaches that will be required to address and understand the complex interplay between food safety and animal production.

Persistence --- Salmonella --- Poultry --- Transmission --- Bacterial Foodborne Pathogens --- Survival --- Production Animals

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Besides causing direct damage associated with blood feeding and in some cases through the excretion of toxins with their saliva, the main relevance of ticks lies in the wide variety of pathogens that they can transmit, including viruses, bacteria, protozoa and helminths. Owing to socioeconomic and environmental changes, tick distribution is changing with incursions of ticks and tick-borne diseases occurring in different regions of the world when the widespread deployment of chemical acaricides and repellents has led to the selection of resistance in multiple populations of ticks. New approaches that are environmentally sustainable and that provide broad protection against current and future tick-borne pathogen (TBP) are thus urgently needed. Such development, however, requires improved understanding of factors resulting in vector competence and tick-host-pathogen interactions. This Research Topic provides an overview of known molecular tick-host-pathogen interactions for a number of TBPs and highlights how this knowledge can contribute to novel control and prevention strategies for tick-borne diseases.

transmission --- Ticks --- host --- tick-borne Pathogens --- pathogen --- Vector --- Tick-Borne Diseases --- transmission --- Ticks --- host --- tick-borne Pathogens --- pathogen --- Vector --- Tick-Borne Diseases

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Besides causing direct damage associated with blood feeding and in some cases through the excretion of toxins with their saliva, the main relevance of ticks lies in the wide variety of pathogens that they can transmit, including viruses, bacteria, protozoa and helminths. Owing to socioeconomic and environmental changes, tick distribution is changing with incursions of ticks and tick-borne diseases occurring in different regions of the world when the widespread deployment of chemical acaricides and repellents has led to the selection of resistance in multiple populations of ticks. New approaches that are environmentally sustainable and that provide broad protection against current and future tick-borne pathogen (TBP) are thus urgently needed. Such development, however, requires improved understanding of factors resulting in vector competence and tick-host-pathogen interactions. This Research Topic provides an overview of known molecular tick-host-pathogen interactions for a number of TBPs and highlights how this knowledge can contribute to novel control and prevention strategies for tick-borne diseases.

transmission --- Ticks --- host --- tick-borne Pathogens --- pathogen --- Vector --- Tick-Borne Diseases