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This practical text supports occupational therapy students and educators as they navigate the opportunities and challenges of practice learning. Reflecting contemporary and innovative occupation-centred practice, it sets out a step-by-step guide to using this knowledge across a range of settings. The clear structure, templates, examples and strategies it presents demonstrate how contemporary theory can be used to inform and guide practice.
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The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This Special Issue of Cancers initially reviews the role of AR in advanced prostate cancer, and then explores the potential importance of AR signaling in other epithelial malignancies. The first few articles focus on the use of novel AR-targeting therapies in castration-resistant prostate cancer and the mechanisms of resistance to novel antiandrogens, and they also outline the interaction between AR and other cellular pathways, including PI3 kinase signaling, transcriptional regulation, angiogenesis, stromal factors, Wnt signaling, and epigenetic regulation in prostate cancer. The next several articles review the possible role of androgens and AR signaling in breast cancer, bladder cancer, salivary gland cancer, and hepatocellular carcinoma, as well as the potential treatment implications of using antiandrogen therapies in these non-prostatic malignancies.
Prostate --- Cancer --- Alternative treatment.
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Management of High Altitude Pathophysiology presents a comprehensive overview on the various therapeutic practices and ongoing research relating to the development of more potent and novel formulations for managing high altitude pathophysiology. It provides a detailed application of both herbal and non-herbal therapeutic agents, including their nanoformulations. This important reference provides benefits to the medical and herbal scientific communities, doctors treating patients with high altitude complications, individuals travelling to high altitudes for recreation or work, and scientists working on future drug development.
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Sans doute la folie douce s'oppose-t-elle à la folie furieuse, qui se manifeste dans des passages à l'acte souvent violents. Joseph Rouzel poursuit sa réflexion sur les liens entre psychose et création. Dans la foulée de son ouvrage La folie créatrice, l'auteur soutient une alternative au traitement des psychotiques. Très souvent, dans ses créations et productions, un psychotique met en œuvre une forme d'auto-traitement qui lui procure un certain apaisement et appelle à une reconnaissance du corps social. Encore faut-il, et d'une : qu'on lui foute la paix ; et de deux : que ses productions, créations, inventions, trouvailles soient accueillies comme faisant signes d'un sujet et non d'un dysfonctionnement. À partir de récits de vies singulières (Jeannot et son plancher ; Glenn Gould et la musique ; Marcel Bascoulard, clochard céleste…), parfois tirés de l'expérience clinique (la sienne ou d'autres), l'auteur poursuit une nécessaire élaboration théorique dans le fil des histoires ici contées.
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