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This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD). The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts. .

Pathological haematology --- stamcellen --- hematologie

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This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery. Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to understand the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential. Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke. Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.

Neuropathology --- neurologie --- stamcellen --- hersenen --- neurochirurgie --- biotechnologie

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This volume provides a comprehensive and state-of-the-art review on pediatric hematopoietic stem cell transplantation (HSCT). The book covers such topics as graft versus host disease (GVHD), HSC mobilization, stem cell selection, and HSCT-relevant laboratory assays and techniques. The text is specially formatted so that the scientific basis of HSCT and ethical considerations are integrated into the relevant clinical framework. Each chapter also includes diagrams, illustrations, and tables that summarize key points and concepts that can be used as a quick visual reference for the reader. Written by experts in the field, Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist is a valuable resource on pediatric HSCT suited for pediatric hematologists-oncologists, fellows, advanced practitioners, clinical nurses, and other referring physicians.

Oncology. Neoplasms --- Pathological haematology --- stamcellen --- oncologie --- hematologie

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This volume of the Subcellular Biochemistry series, Biochemistry and Cell Biology of Ageing: Part I is devoted broadly to Biomedical aspects of Ageing. The 17 chapters included in the book, contributed by knowledgeable authors, review many important topics at an advanced level. Ageing in relation to reactive oxygen species (ROS) and the importance of Antioxidant Vitamins and Antioxidant Enzymes are given prominent coverage. Consideration is also given to Vitamin D and the B Vitamins. Chapters on Nutrition, Nutrient Sensing, the Microbiome and Signal Transduction appear, along with Cholesterol Metabolism, Creatine and Creatine Kinase, Extracellular Matrix, Stem cells, Nuclear DNA Damage, Teleomere Length, Gene Expression and Epigenetics, Autophagy and protein Glycosylation. The book is primarily directed to advanced biomedical science and medical students, postgraduates, researchers and academics in the field of Ageing. A further supplementary volume of the Subcellular Biochemistry series, Biochemistry and Cell Biology of Ageing: Part II, covering the more Clinical Science aspects of ageing, will be published soon. Prof. J. Robin Harris is an Honorary Professor of the University of Mainz, he has broad biomedical science and electron microscopical experience and is actively involved in scientific publishing. Dr. Viktor I. Korolchuk is a Reader in Molecular Cell Biology at Newcastle University and is actively involved in cellular autophagy studies. .

Human physiology --- stamcellen --- autofagie --- fysiologie --- moleculaire biologie --- enzymen

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This updated edition provides clinicians from various backgrounds and levels of training the information needed to optimally diagnose and manage neurologic complications of the nervous system. Organized into seven sections, this comprehensive volume begins with an overview of diagnostic studies for neurologic complications involving the nervous system. That is followed by sections on metastatic and non-metastatic complications of cancer involving the nervous system, and the interpretation, diagnosis, and management of common neuro-oncologic symptoms. The next section reviews the neurologic complications of cancer therapy, including corticosteroids, radiation therapy, chemotherapy, targeted molecular therapies, immunotherapies, hematopoietic stem cell transplantation, and infections involving the nervous system. The final section focuses on the most important neurologic complications in cancers arising from specific organs. In addition to capturing the latest advancements in the rapidly evolving fields of oncology and cancer neurology, the goal of this resource is to lead clinicians toward prompt diagnosis and intervention in order to improve patient quality of life. "This textbook is a valuable resource for medical oncologists and radiation oncologists, as well as neurologists and neuro-oncologists dealing with these patients. … Overall, the chapters are well organized, clearly written, fairly balanced, and reasonably up to date. … I would recommend it as a learning tool to physicians in training (medical students, residents, and fellows) and for more experienced physicians as both a review/ update and a way to gain more in-depth knowledge and insight into the neurologic problems of cancer patients." (John C. Flickinger, International Journal of Radiation Oncology Biology Physics, Vol. 73 (2), 2009) "The general organization of the book is logical and facilitates its practical and everyday use. … Overall this textbook is very comprehensive and encompasses main neuro-oncological challenges. … Schiff, Kesari and Wen have edited a very elegant and highly practical textbook, written by recognized authorities in their respective fields, which will be used by a wide range of medical and surgical specialists who are confronted on a daily basis with neurological manifestations of cancer in their practice." (I. Radovanovic and G. Zadeh, British Journal of Cancer, Vol. 100 (6), 2009).

Oncology. Neoplasms --- Neuropathology --- stamcellen --- hersenen --- oncologie --- metastase --- moleculaire biologie