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This book outlines the interaction of cadmium with the proteome and signalling molecules of mammalian cells. Chapters from expert contributors cover topics such as cadmium chemical biology, membrane receptors and transporters for cadmium and cadmium complexes, and targets of cadmium toxicity. Students and researchers working in bioinorganic chemistry will find this book an important account.

Biochemistry. --- Chemistry, inorganic. --- Cell membranes. --- Animal Biochemistry. --- Inorganic Chemistry. --- Membrane Biology. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Inorganic chemistry --- Chemistry --- Inorganic compounds --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Composition --- Inorganic chemistry. --- Cell membranes .

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This book mainly focuses on key aspects of biomembranes that have emerged over the past 15 years. It covers static and dynamic descriptions, as well as modeling for membrane organization and shape at the local and global (at the cell level) scale. It also discusses several new developments in non-equilibrium aspects that have not yet been covered elsewhere. Biological membranes are the seat of interactions between cells and the rest of the world, and internally, they are at the core of complex dynamic reorganizations and chemical reactions. Despite the long tradition of membrane research in biophysics, the physics of cell membranes as well as of biomimetic or synthetic membranes is a rapidly developing field. Though successful books have already been published on this topic over the past decades, none include the most recent advances. Additionally, in this domain, the traditional distinction between biological and physical approaches tends to blur. This book gathers the most recent advances in this area, and will benefit biologists and physicists alike. .

Membranes (Biology) --- Biophysics. --- Biochemistry. --- Cell membranes. --- Biochemistry, general. --- Membrane Biology. --- Biological and Medical Physics, Biophysics. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Glycocalyces --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Cell membranes . --- Biological physics. --- Biological physics --- Physics

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This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks’ output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms’ development. .

Endocytosis. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Absorption (Physiology) --- Cell physiology --- Cell membranes. --- Cell physiology. --- Cell cycle. --- Biochemistry. --- Membrane Biology. --- Cell Physiology. --- Cell Cycle Analysis. --- Protein Science. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Mitotic cycle --- Nuclear cycle (Cytology) --- Biological rhythms --- Cell function --- Cytology --- Physiology --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Composition --- Cell membranes . --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Biological transport. --- Cytology. --- Proteins. --- Membrane Trafficking. --- Cell Biology. --- Cytological Techniques. --- Protein Biochemistry. --- Technique. --- Membrane transport --- Passive transport, Biological --- Physiological transport --- Transport, Biological --- Diffusion --- Osmosis --- Cell biology --- Cellular biology --- Cells

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This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.

Calcium --- T cells --- Nuclear magnetic resonance. --- Metabolism --- Regulation. --- Receptors. --- Magnetic resonance, Nuclear --- NMR (Nuclear magnetic resonance) --- Nuclear spin resonance --- Resonance, Nuclear spin --- T cell receptors --- T lymphocyte antigen receptors --- Engineering. --- Immunology. --- Cell membranes. --- Atomic structure. --- Molecular structure. --- Spectra. --- Biomedical engineering. --- Biomedical Engineering. --- Biological and Medical Physics, Biophysics. --- Membrane Biology. --- Atomic/Molecular Structure and Spectra. --- Magnetic resonance --- Nuclear spin --- Nuclear quadrupole resonance --- Cell receptors --- Biomedical Engineering and Bioengineering. --- Immunobiology --- Life sciences --- Serology --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Biophysics. --- Biological physics. --- Cell membranes . --- Atomic structure  . --- Molecular structure . --- Biological physics --- Biology --- Medical sciences --- Physics --- Structure, Atomic --- Atomic theory --- Structure, Molecular --- Chemical structure --- Structural bioinformatics