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Digital
Advancing Development of Synthetic Gene Regulators : With the Power of High-Throughput Sequencing in Chemical Biology
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ISBN: 9789811065477 Year: 2018 Publisher: Singapore Springer Singapore, Imprint: Springer

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This book focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence. .


Dissertation
Master thesis : Microstructure prediction of Ti6Al4V processed by Laser Cladding
Authors: --- --- --- --- --- et al.
Year: 2018 Publisher: Liège Université de Liège (ULiège)

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Abstract 
Titanium is the fourth most abundant structural metal in the world. It is known to have a high strength, light weight, good formability and high corrosion resistance. Due to these properties, Titanium and its alloys are used in many industries, such as aerospace and automobile. Note that due to its high price, one can find Ti6Al4V in demanding applications. 
This master thesis defines quantitatively predicting of the microstructure of a titanium alloy, Ti6Al4V, worked with laser cladding process. The main goal is to define the proper phase transformation conditions that lead to reliable phase predictions. 
Outcomes are checked from the results obtained by two experimental observations in laser cladding process for the Ti6Al4V. Both studies obtained qualitative results according to the phases that formed the microstructure of the alloy and the hardness value of three different points located in the deposits. As a first reference, H.S. Tran used Constant Track Length building strategy. The second study has been made by MMS team at University of Liège, but it has not been published yet. They used a Decrease Track Length building strategy. The initial experimental work was done by H.Paydas .
This master thesis is based on the implementation of a Fortran code that defines the phase transformations of Ti6Al4V. Inside the code, the thermal conditions and the equations with their parameters are defined. The project was based on Crespo’s model that calculates the phase transformation kinetics of this titanium alloy. After applying the same model, some differences have been made in order to achieve the desired results according to the improvement works done by H.S Tran and MMS team. 
This document presents a flow work starting with the basic theoretical background about Additive Manufacturing, Titanium and its alloys. After, Ti6Al4V is presented: its chemical composition, the different phases that can describe its microstructure and the equations that define the transformations from one phase to the other. The parameters and conditions defining those equations are determined and compared with previous literature, concretely with Crespo. Finally the results and conclusions are presented. 
Keywords: Laser Cladding (LC), Ti6Al4V, microstructure, thermal history, Fortran.


Digital
Heat Stability of Concentrated Milk Systems : Kinetics of the Dissociation and Aggregation in High Heated Concentrated Milk Systems
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ISBN: 9783658196967 Year: 2018 Publisher: Wiesbaden Springer Fachmedien Wiesbaden, Imprint: Springer Spektrum

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In his study, Joseph Dumpler proves a strong correlation between the dry matter content of the milk concentrate and the maximum temperature-time combinations for the heat treatment of concentrated skim milk without visible coagulation. The author also states that direct heat treatment is superior to indirect heat treatment for preservation of liquid milk concentrates or decontamination of concentrated milk before spray drying. Contents Heat Stability of Concentrated Milk  Heat-Induced Coagulation of Concentrated Milk Heated by Direct Steam Injection Dissociation and Coagulation of Caseins and Whey Proteins Modelling of Heat Stability and Heat-Induced Aggregation of Casein Micelles Mechanistic Aspects of Heat-Induced Coagulation Target Groups Lecturers and students of dairy science and technology, food science and processing Practitioners and suppliers of processing equipment in the fields of dairying, food processing, food process engineering The Author During his PhD, Joseph Dumpler was employed as a scientific officer at the Chair Food and Bioprocess Engineering at the TUM School of Life Sciences Weihenstephan of the Technical University of Munich. His research was focused on the heat stability and heat treatment of concentrated milk by direct steam injection technology.


Digital
Advanced Characterization Techniques, Diagnostic Tools and Evaluation Methods in Heritage Science
Authors: ---
ISBN: 9783319753164 Year: 2018 Publisher: Cham Springer International Publishing

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This book details the application of advanced characterisation techniques and diagnostic tools to heritage science, including the evaluation of heritage assets’ condition, their preservation and restoration. It examines the use of electrochemical techniques in conservation science, with a particular focus on how to solve problems in taking on-site measurements. Specifically, it introduces readers to a new gel polymer (GPE) electrochemical cell developed by the authors for the characterisation of metallic heritage objects. Other techniques used to characterise and monitor reinforced concrete objects in more modern buildings are also covered, including non-destructive electrochemical techniques that allow steel corrosion to be assessed in these structures, and in those that are used to protect and repair such buildings. The usefulness of the NMR-Mouse nuclear magnetic resonance sensor in the assessment and preservation of softer heritage materials, such as wood, parchment, bone, and painted walls, is covered, as well as Infrared reflectography for examining paintings and laser cleaning for restoring them. The book introduces ultra-High Performance Liquid Chromatography (u-HPLC) with a diode-array (DAD) and mass–mass (MS-MS) quadruple time-of-flight spectroscopy (QTOF). This new technique can be applied to the analysis and identification of natural and synthetic organic pigments and its use is demonstrated in several case studies. This book provides a rigorous scientific grounding in the application of state-of-the-art techniques in heritage science and conservation, and offers a practical handbook for practitioners.


Digital
Analytical Methods for the Assessment of Maillard Reactions in Foods
Authors: --- --- --- ---
ISBN: 9783319769233 Year: 2018 Publisher: Cham Springer International Publishing

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This Brief provides an overview of different analytical methods and techniques for the qualitative and quantitative evaluation of Maillard Reactions and their reaction products in foods during processing and storage. Reliable methodology for the investigation of Maillard Reactions and their products are of utmost importance in food analysis: since Maillard Reactions can on the one hand be desirable and advantageous, influencing the colors, flavors and odors of food products, they can on the other hand also produce detrimental compounds afflicting the consumers’ health (e.g. furfurals, furosine, or acrylamide). This Brief introduces different analytical methods, which can be used to investigate and characterize Maillard Reactions and their products in foods, including for example capillary electrophoresis, high performance liquid chromatography, gas chromatography with mass spectrometric detection, UV-VIS spectrophotometry, fluorescence, electronic nose, gravimetric systems, and many more. The chapters exemplify how the analytical techniques can be applied for assessing and evaluating different Maillard Reaction products in foods. Readers will find basic information, as well as practical hints and guidelines for application in their own laboratory.


Book
Principles of instrumental analysis
Authors: --- ---
ISBN: 9781305577213 1305577213 8000010402 1337468037 9789353506193 9353506190 Year: 2018 Publisher: Australia CENGAGE Learning

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This book places an emphasis on operating principles of each type of instrument, its optimal area of application, its sensitivity, its precision, and its limitations. You'll also learn about elementary analog and digital electronics, computers, and the treatment of analytical data. The book companion website has supplemental tutorials on instrumental methods, Excel files of data analysis and simulations of analytical techniques to help you visualize important concepts in this course, and selected papers from the chemical literature to stimulate interest.


Book
Looking Forward to the Future of Heparin: New Sources, Developments and Applications
Authors: ---
ISBN: 3038429503 303842949X Year: 2018 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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This book is a printed edition of the Special Issue Looking Forward to the Future of Heparin: New Sources, Developments and Applications that was published in Molecules

Keywords

alginate --- n/a --- edema --- Heparin Red --- solid lipid nanoparticles --- Fe3O4·DA-BSA/HA --- dermatan sulfate --- sulfated alginate --- porcine heparin --- theranostics --- low-molecular-weight heparin --- Arixtra® --- biomaterials --- hepcidin --- ovarian cancer --- iron oxide nanoparticles --- heparin-induced thrombocytopenia --- bone morphogenetic protein (BMP) --- hyaluronic acid (HA) --- crude heparin --- platelets --- resistance --- sclerostin --- LMWH --- gremlin --- low molecular weight heparin (LMWH) --- low molecular weight glycosaminoglycans --- human plasma --- single crystal X-ray structure --- iron homeostasis --- noggin --- super paramagnetic iron oxide nanoparticles (SPION) --- manufacturing methods --- paclitaxel (PTX) --- brain injury --- bovine heparin --- inflammation --- qNMR --- antithrombin --- reference standard --- quantitative NMR --- enoxaparin --- danaparoid sodium --- NMR --- GDNF --- orthogonal multi-analytical methods --- ternary complex --- heparan sulphate --- serglycin --- bovine serum albumin (BSA) --- HSQC --- recombinant expression --- heparin --- heparin oligosaccharides --- functional assay --- BMP antagonists --- intestinal lymphatic absorption --- size exclusion chromatography --- heparin coating --- diagnosis --- bioreactor --- anemia --- proteoglycan --- heparin process --- PCA --- chemometric --- fluorescent probe --- pharmacopeia --- affinity chromatography --- component quantitative analysis --- Fondaparinux sodium --- perylene diimide dyes --- thrombin inhibition --- extended physicochemical characterization --- cisplatin --- glycosaminoglycans --- TGF-? --- chondroitin sulfate --- dalteparin --- sequence and compositional investigations --- molecular weight --- magnetic resonance imaging (MRI) --- industrial --- LC-MS --- iduronic acid conformation --- heparan sulfate --- growth and differentiation factor (GDF) --- assay --- subarachnoid hemorrhage


Book
Archaeology and urban settlement in late Roman and Byzantine Anatolia : Euchaïta-Avkat-Beyözü and its environment
Authors: --- ---
ISBN: 9781108471152 1108471153 9781108557757 9781108457224 1108557759 1316998002 1108698174 Year: 2018 Publisher: Cambridge : Cambridge University Press,

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The site of medieval Euchaïta, on the northern edge of the central Anatolian plateau, was the centre of the cult of St Theodore Tiro ('the Recruit'). Unlike most excavated or surveyed urban centres of the Byzantine period, Euchaïta was never a major metropolis, cultural centre or extensive urban site, although it had a military function from the seventh to ninth centuries. Its significance lies precisely in the fact that as a small provincial town, something of a backwater, it was probably more typical of the 'average' provincial Anatolian urban settlement, yet almost nothing is known about such sites. This volume represents the results of a collaborative project that integrates archaeological survey work with other disciplines in a unified approach to the region both to enhance understanding of the history of Byzantine provincial society and to illustrate the application of innovative approaches to field survey.

Keywords

Excavations (Archaeology) --- Cities and towns, Ancient --- Cities and towns. --- Civilization. --- Classical antiquities. --- To 1500 --- Beyözü (Turkey) --- Turkey --- Byzantine Empire. --- Turkey. --- Antiquities. --- Antiquities, Roman. --- Antiquities, Byzantine. --- Geography, Ancient --- Anatolia --- Anatolie --- Ānātūlī --- Asia Minor --- Asia Minore --- Bu̇gd Naĭramdakh Turk Uls --- Buturuki --- Cộng hoà Thỏ̂ Nhĩ Kỳ --- Dēmokratia tēs Tourkias --- Devlet-i Aliye Osmaniye --- Durka --- Durkka dásseváldi --- Gweriniaeth Twrci --- Jamhuri ya Uturuki --- Jamhuuriyada Turki --- Jumhūrīyah al-Turkīyah --- Komara Tirkiyeyê --- Lýðveldið Turkaland --- Lýðveldið Tyrkland --- Orílẹ̀-èdè Olómìnira ilẹ̀ Túrkì --- Osmanlı İmparatorluğu --- Osmanskai︠a︡ Imperii︠a︡ --- Ottoman Empire --- Pobblaght ny Turkee --- Poblacht na Tuirce --- Repóbblica d'l Turchî --- Repubbleche de Turchie --- Repubblica di Turchia --- Republic of Turkey --- Republic of Türkiye --- República da Turquia --- Republica de Turchia --- Republica de Turquía --- Republica Turcia --- Republiek Turkeye --- Republiek Turkije --- Republiek van Turkye --- Republik bu Tirki --- Republik Tierkei --- Republik Turkäi --- Republik Türkei --- Républik Turki --- Republik Turkia --- Republika e Turqisë --- Republika ng Turkiya --- Repùblika Tërecczi --- Republika Turcija --- Republika Turcji --- Republika Turcyje --- Republika Turecko --- Republika Turkiya --- Republika Turkojska --- Republika Turska --- Republika Turt︠s︡ii︠a︡ --- Republiḳah ha-Ṭurḳiyah --- Republiken Turkiet --- Republikken Tyrkia --- Republikken Tyrkiet --- République de Turquie --- République turque --- Repuvlika de Turkiya --- Ripablik kya Buturuki --- Ripoliku Turkiyakondre --- T.C. (Türkiye Cumhuriyeti) --- Tagduda n Tturk --- TC --- Teki --- Tëreckô --- Ṭerḳay --- Ṭerḳishe Republiḳ --- Thekhi --- Thỏ̂ Nhĩ Kỳ --- Thú-ngí-khì --- Tiakei --- Tierkei --- Tiki --- Tirki --- Tırkiya --- Tirkiye --- Ti︠u︡rk --- Ti︠u︡rk Respublika --- Ti︠u︡rkii︠a︡ --- Ti︠u︡rkii︠a︡ Respublika --- Tlacatlahtocayotl Turquia --- Tʻŏkʻi --- T'ŏk'i Konghwaguk --- Tʼóok Bikéyah --- Torkėjė --- Tȯrkiă --- Törkie --- Törkieë --- Tȯrkii︠a︡ --- Tȯrkii︠a︡ Jȯmḣu̇rii︠a︡te --- Török Köztársaság --- Törökország --- Toruko --- Toruko Kyōwakoku --- Tourkia --- Tourkikē Dēmokratia --- Tturk --- Tu er qi gong he guo --- Tū-ī-gì --- Tū-ī-gì Gê̤ṳng-huò-guók --- Tu'erqi --- Tu'erqi gong he guo --- Tu'erqi Gongheguo --- Tuirc --- Tunkī --- Turchî --- Turchia --- Turchie --- Turchy Respublikæ --- Turcia --- Turcija --- Turcijas Republika --- Turcja --- Turcland --- Turcyjo --- Turechchyna --- Turecká republika --- Turecko --- Tureke --- Turet︠s︡ka Respublika --- Turėtskai︠a︡ Rėspublika --- Tureuki --- Türgi --- Türgi Vabariik --- Türgü --- Türgü Vabariik --- Turk --- Turkäi --- Turkaland --- Turkamastor --- Türkän --- Turkanʹ respubliksʹ --- Turkee --- Türkei --- Turkeya --- Turkeye --- Turki --- Turkia --- Turkia Respubliko --- Turkieë --- Turkiet --- Turkii --- Tu̇rkii︠a︡ --- Tu̇rkii︠a︡ Respublikasy --- Tu̇rkiĭė --- Tu̇rkiĭė Respublikata --- Turkija --- Turkije --- Turkin tasavalta --- Turkio --- Turkiyā --- Turkiya Republika --- Türkiyä Respublikası --- Turkiyah --- Turkiyakondre --- Türkiye --- Türkiye Cumhuriyeti --- Türkiýe Respublikasy --- Turkki --- Turkojska --- Turkowska --- Turkujo --- Turkya --- Turkyah --- Turkye --- Turqia --- Turquía --- Turquie (Repupblic) --- Turska --- Turtchie --- Turt︠s︡i --- Turt︠s︡i Respubliki --- Turt︠s︡iĭ --- Turt︠s︡ii︠a︡ --- Turtsyi︠a︡ --- Turukiya --- Tuykia --- Twrci --- Tyrkia --- Tyrkiet --- Tyrkland --- Tẏrt︠s︡i --- Uturuki --- Vysokai︠a︡ Porta --- Whenua Korukoru --- Τουρκική Δημοκρατία --- Τουρκία --- Δημοκρατία της Τουρκίας --- Република Турска --- Република Турция --- Република Турција --- Турска --- Турцыя --- Турци --- Турци Республики --- Турция --- Турција --- Турций --- Турція --- Турчы Республикæ --- Турэцкая Рэспубліка --- Турк --- Туркань республиксь --- Туркамастор --- Турецька Республіка --- Турецка Республіка --- Турецкая Республика --- Туреччина --- Тюрк --- Тюрк Республика --- Тюркия --- Тюркия Республика --- רפובליקה הטורקית --- תורכיה --- טערקישע רעפובליק --- טערקיי --- טורקיה --- تركيا --- جمهورية التركية --- トルコ --- トルコ共和国 --- 土耳其 --- 土耳其共和國 --- 터키 --- 터키 공화국 --- Avkat (Turkey) --- Euchaita (Mecitözü İlçesi, Turkey)

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