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This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.

Extracellular matrix. --- Heart --- Cytology. --- Cement substance (Anatomy) --- Ground substance (Anatomy) --- Ground substance (Histology) --- Intercellular matrix --- Interstitial substance --- Matrix, Extracellular --- Connective tissues --- Extracellular space --- Cardiology. --- Biomedical engineering. --- Cell Biology. --- Biomedical Engineering/Biotechnology. --- Cardiac Surgery. --- Surgery. --- Cardiac surgery --- Open-heart surgery --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Internal medicine --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Diseases --- Surgery --- Myocardium --- Extracellular Matrix. --- Extracellular Matrix Proteins. --- cytology. --- physiology. --- Extracelllular Matrix Proteins. --- Extracellular Matrices --- Matrices, Extracellular --- Matrix Proteins, Extracellular --- Proteins, Extracellular Matrix --- Extracellular Traps --- Extracellular Matrix Protein --- Matrix Protein, Extracellular --- Protein, Extracellular Matrix --- Cell biology. --- Cardiac surgery.