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Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide and is estimated to become the third most common cause of death over the next decade. The knowledge of COPD pathogenesis and the disease course has greatly improved this progression in understanding and continues to have significant implications in the management of this condition. Novel areas of interest in COPD pathogenesis include further development of animal models, a better understanding of the genetics and epigenetics, the role of the microbiome, and an increasing appreciation of the associated comorbidities. This book intends to provide the reader with a brief overview of these topics and also provide an in-depth review of the current nonpharmacological clinical approaches to managing patients with COPD.

Lungs --- Diseases, Obstructive. --- Chronic obstructive pulmonary disease --- COPD (Disease) --- Lung diseases, Obstructive --- Obstructive lung diseases --- Respiratory organs --- Diseases --- Obstructions --- Medicine --- Pulmonology --- Internal Medicine --- Health Sciences

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This volume in the series, Translational Bioinformatics, provides an up-to-date overview of genomic approaches to asthma. By applying unbiased “-omics” combined with disease-focused and hypothesis-driven approaches, it enhances readers’ understanding of the asthma endotype. Furthermore, it elucidates how progress in -omics research, such as “genomic,” “transcriptomic,” “protomic,” and “metabolomic,” is applied in asthma, and reports on the related series of important breakthroughs in asthma development, classification, prevention and drug sensitivity. Also covering systems biology knowledge and methodologies, computational models and biostatistical methods to analyze big data, this book provides a valuable resource for scientists and researchers in the field of asthma and respiratory diseases.

Life sciences. --- Human physiology. --- Bioinformatics. --- Life Sciences. --- Human Physiology. --- Asthma. --- Bronchial asthma --- Bronchi --- Lungs --- Respiratory allergy --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Biosciences --- Sciences, Life --- Science --- Diseases --- Diseases, Obstructive --- Data processing --- Human biology --- Medical sciences --- Physiology --- Human body