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Metabolic pathways involved in photosynthesis and biosynthesis of lipids, hydrogen or growth are typically regulated by complex interdependent mechanisms involving multiple fronts of omics (genomics, transcriptomics, proteomics, …). Here, we apply Constraint-Based Modelling (CBM) techniques on a genome-scale metabolic network reconstruction of C. reinhardtii, and improve the model by integrating constraints from a Transcriptional Regulation Network, thus taking into account cell gene expression shifts under envrionmental changes.

Chlamydomonas Reinhardtii Metabolic Network Constraint-Based Modelling Transcriptomic Regulation --- Sciences du vivant > Biochimie, biophysique & biologie moléculaire