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"Written by a Who's Who of renowned spine surgeons, the third edition of Neurosurgical Atlas: Spine and Peripheral Nerves provides a detailed tutorial on the latest surgical procedures. The three comprehensive spine sections cover decompression modalities followed by fusion/instrumentation and fixation. Rounding out these sections are special topics such as vascular malformations in the spinal cord, stereotactic radiosurgery in the thoracic spine, and lumboperitoneal shunting. The peripheral nerves section includes treatment of conditions including carpal tunnel, brachial plexus, meralgia paresthetica, and cervical nerve root avulsion."
Spine --- Nerves, Peripheral --- Surgery.
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Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge.
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This book focuses on posttraumatic repair and reconstruction of peripheral nerves. Written by internationally respected specialists, it provides an overview of the challenges and the latest advances in diagnosis and treatment of traumatic peripheral nerve injuries. It presents an outline of state-of the-art procedures from diagnostics, including newest imaging techniques, over conventional and alternative surgical approaches to clinical follow-up and rehabilitation, including the latest concepts to improve functional recovery. The purely clinical topics are preceded by neuroanatomical principles and neurobiological events related to peripheral nerve transection injuries and followed by an outlook on current experimental developments in the area of biomaterials for artificial nerve grafts and peripheral nerve tissue engineering. Peripheral nerve injuries not only affect the nerve tissue at the site of injury, but also target tissue and parts of the central nervous system. They often have dramatic consequences for patients, including loss of sensory and motor functions combined with paresthesia or pain, and a reduced quality of life and ability to work. An adequate understanding of the procedures for proper decision-making and reconstructing peripheral nerves is therefore essential to ensure optimized functional recovery.
Medicine. --- Neurosciences. --- Neurology. --- Neurosurgery. --- Medicine & Public Health. --- Nerves, Peripheral --- Regeneration. --- Growth. --- Transplantation. --- Nervous system, Peripheral --- Peripheral nerves --- Peripheral nervous system --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Nerves --- Neurosurgery --- Medicine --- Neuropsychiatry --- Surgery --- Diseases --- Neurology .
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This thoroughly updated edition covers all clinical aspects of neuroinflammation. The latest developments in pathogenesis and advances in treatment are provided, along with an understanding of the immune system's role and interactions between the activated immune cells, cerebral endothelial cells, and other main components of the immune cascade. Cutting-edge and authoritative, this volume offers practitioners a valuable resource for research and clinical practice.
Neuritis. --- Nervous system --- Pathophysiology. --- Nerves, Peripheral --- Inflammation --- Medicine. --- Neurology. --- Medicine & Public Health. --- Diseases --- Medicine --- Neuropsychiatry --- Neurology .
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Le système nerveux, qui commande et régit toutes les fonctions de l'organisme, a toujours été un important sujet d'observation pour Andrew Taylor Still, le fondateur de l'ostéopathie. Les auteurs, ostéopathes français réputés internationalement pour la qualité de leur enseignement, présentent dans ce livre une toute nouvelle approche du système nerveux périphérique basée sur un diagnostic rapide et précis des points critiques à traiter.L'ouvrage expose de façon didactique l'étiologie des lésions ostéopathiques du nerf, leur correspondance avec les points majeurs de l'acupuncture et, sous forme de fiches pratiques, un répertoire des principaux points clés du système nerveux périphérique avec leurs correspondances cliniques dans de nombreuses pathologies fonctionnelles, douloureuses ou non. La qualité de l'iconographie qui compte plus de 200 illustrations originales - schémas, dissections et photos réalisés personnellement par les auteurs permet au lecteur de visualiser clairement l'anatomie des nerfs ainsi que la meilleure façon d'aborder le point neural.Un chapitre entier consacré à l'encéphale et aux nouvelles perspectives de traitement ostéopathique qui sont offertes dans ce domaine complète parfaitement ce livre de référence sur l'approche manuelle du système nerveux. Cet ouvrage s'adresse à tous les ostéopathes et professionnels de santé qui souhaitent étendre leur champ de compétence en intégrant d'une façon simple mais efficace l'évaluation et le traitement du "lien neurologique" dans leur pratique.
Ostéopathie. --- Nerfs périphériques --- Osteopathic medicine. --- Nerves, Peripheral --- Lésions et blessures. --- Wounds and injuries.
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The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A better comprehension of these powerhouses of disease immunity will likely facilitate development to unprecedented and specific therapies to fight chronic inflammatory diseases.
Autoimmunity --- nonresolving peripheral tissue inflammation --- Autoinflammation --- Tertiary lymphoid organs --- dichotomies of immune responses --- disease immunity --- Immune Tolerance --- antigen
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The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A better comprehension of these powerhouses of disease immunity will likely facilitate development to unprecedented and specific therapies to fight chronic inflammatory diseases.
Autoimmunity --- nonresolving peripheral tissue inflammation --- Autoinflammation --- Tertiary lymphoid organs --- dichotomies of immune responses --- disease immunity --- Immune Tolerance --- antigen
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