Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Fungal infections represent nowadays a significant burden on the healthcare system of most of the countries, and are among the infections with the highest mortality rates. This has fostered the study of the interaction of these organisms with the human host. The outer most layer of a fungal cell is the cell wall, and together with the secreted components into the extracellular compartment, are the first lines of contact with the host cells. This interaction is critical for tissue adhesion, colonization and damage. In addition, these fungal extracellular components will define the outcome of the interaction with the host immune cells, leading either to the establishment of a protective antifungal immune response or to an immune-evasive mechanism by the fungal cell. On the other hand, our immune system has effectively evolved to deal with fungal pathogens, developing strategies for cell eradication, burden control, or antigen presentation from the innate branch to the adaptive immune response. Here, we provide a series of comprehensive review papers dealing with both aspect of the interaction fungus-immune cells: the role of virulence factors and cell wall components during such interaction, and the recent advances in the study of cellular receptors in the establishment of a protective anti-fungal immune response.

Candida albicans --- Cell Wall --- Aspergillus --- Histoplasma --- melanin --- Paraccocidioides --- Cryptococcus --- Dermatophytes --- host-fungus interaction --- Candida parapsilosis

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book on Candida albicans and similar pathogens provides a timely overview of the groundbreaking discoveries made in the areas of drug resistance, host–pathogen interactions, virulence, host immune system modulation, etc., in the last two decades. This comprehensive 2nd Edition includes chapters on fungal infections, hyphal morphogenesis, molecular mechanisms of antifungal resistance, antifungal agents, multidrug transporters, virulence mechanisms in Candida albicans, host–pathogen interactions, the cell wall, fungal biofilms, lipids and antifungal resistance, signaling mechanisms and last but not the least host-immune responses. As such, it offers an ideal reference guide for mycologists, researchers, pharmacists, clinicians, and undergraduate students engaged or interested in fungal research. It will also benefit clinicians, who are required to keep abreast of the current state of research on antifungal drug resistance and antifungal development.

Life sciences. --- Drug resistance. --- Molecular biology. --- Cell membranes. --- Mycology. --- Life Sciences. --- Molecular Medicine. --- Drug Resistance. --- Membrane Biology. --- Candida albicans. --- Monilia albicans --- Candida --- Entomology. --- Medicine. --- Drug interactions. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Interactions, Drug --- Drugs --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Insects --- Zoology --- Side effects --- Health Workforce --- Cell membranes . --- Resistance to drugs --- Pharmacology --- Botany --- Fungi --- Microbiology --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Fungal biology --- Fungology --- Fungus biology