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Plant hormones. --- Plant cellular signal transduction. --- Cellular signal transduction --- Plant cellular control mechanisms --- Hormones (Plants) --- Phytohormones --- Hormones --- Phytochemicals --- Plant regulators

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Plus que jamais, les oncologues ont besoin de l’apport de la biologie, d’abord pour comprendre les cancers, mais surtout pour les traiter. Des milliers d’essais thérapeutiques ont été lancés pour évaluer les thérapies innovantes ciblant les mécanismes de l’oncogenèse. Il est maintenant bien établi que le cancer est, d’une certaine façon, une maladie de la signalisation cellulaire : les cellules cancéreuses détournent à leur profit les messages que s’échangent les cellules, masquent ou surexpriment les récepteurs de ces messages, miment de mille façons les voies intracellulaires qui leur permettent de proliférer et d’envahir les tissus voisins ou distants.Afin de ne pas se perdre dans le dédale des voies de signalisation, dans la profusion des récepteurs et des signaux concourant à l’oncogenèse, cet ouvrage propose une vision d’ensemble, simplifiée, didactique et complète des voies de transmission de l’information entre les cellules et à l’intérieur des cellules. Les voies de signalisation sont analysées une à une, mais sans jamais esquiver la complexité de leurs interconnexions. La présentation de chaque voie est suivie d’une brève description des altérations rencontrées dans les cancers et des approches pharmacologiques ciblées qui peuvent être mises en œuvre pour y remédier. Les mécanismes de base de la biologie moléculaire, qui permettent d’expliquer les perturbations des voies de signalisation, font l’objet d’annexes didactiques.Cette nouvelle édition intègre les découvertes récentes de la recherche et apporte des compléments sur des sujets qui n’avaient pas été abordés dans la première édition, en particulier un chapitre sur adhésion et motilité cellulaire et une annexe sur les déviations métaboliques des cellules cancéreuses. Abondamment illustré par des schémas très précis, cet ouvrage sera le compagnon idéal de l’oncologue dans sa quête de nouvelles thérapeutiques anticancéreuses.

Neoplastic cells, Circulating --- Neoplasms --- Stem cells --- Cellules cancéreuses --- Cellules souches --- Cellular signal transduction --- Carcinogenesis --- Cancer cells --- Signal Transduction --- Proliferation --- Neoplasms. --- Neoplastic Cells, Circulating. --- Signal Transduction. --- Stem Cells. --- Cellules cancéreuses. --- Cellules souches.

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Cell interaction. --- Cellular signal transduction. --- Signal Transduction --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cell-cell interaction --- Cell communication --- Cellular communication (Biology) --- Cellular interaction --- Intercellular communication --- physiology. --- 576.5 --- 576.5 Cell interactions. Intercellular junctions. Cell populations. Cell behaviour in culture --- Cell interactions. Intercellular junctions. Cell populations. Cell behaviour in culture --- Transduction du signal cellulaire --- Cellules --- Interaction --- Transduction du signal cellulaire. --- Interaction. --- Cellular signal transduction --- physiology

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Neurotransmitters --- Neurotransmitter receptors --- Neurons --- Neuroglia --- Synaptic Transmission. --- Receptors, Neurotransmitter. --- Signal Transduction. --- Neurons. --- Neuroglia. --- Neurotransmitter receptors. --- neurotransmitters --- ion channels --- receptors --- neurodegeneration --- neuropharmacology --- hormone --- Chemical nerve transmitters --- Nerve transmitter substances --- Neural transmitters --- Neurohumors --- Neuroregulators --- Synaptic transmitters --- Transmitters, Chemical nerve --- Transmitters, Synaptic --- Neurochemistry --- Neural transmission --- Nerve Cells --- Cell, Nerve --- Cells, Nerve --- Nerve Cell --- Neuron --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Neuromediator Receptor --- Neuromodulator Receptor --- Neuroregulator Receptor --- Neurotransmitter Receptor --- Receptors, Neuromediators --- Receptors, Neuromodulators --- Receptors, Neuroregulators --- Receptors, Neurotransmitters --- Neurohumor Receptors --- Neuromediator Receptors --- Neuromodulator Receptors --- Neuroregulator Receptors --- Receptors, Neurohumor --- Receptors, Synaptic --- Synaptic Receptors --- Neuromediators Receptors --- Neuromodulators Receptors --- Neuroregulators Receptors --- Neurotransmitter Receptors --- Neurotransmitters Receptors --- Receptor, Neuromediator --- Receptor, Neuromodulator --- Receptor, Neuroregulator --- Receptor, Neurotransmitter --- Receptors, Neuromediator --- Receptors, Neuromodulator --- Receptors, Neuroregulator --- Transmission, Neural --- Transmission, Synaptic --- Neural Transmission --- Neurotransmission --- Neural Conduction --- Synapses --- Glial cells --- Nerve tissue --- Nerves --- Nerve cells --- Neurocytes --- Cells --- Nervous system --- Receptors, Neurotransmitter --- Cell receptors --- Hormone receptors --- Neural receptors --- Cell Signaling --- Neurostransmitters --- Synaptic Receptor --- Receptor, Synaptic

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This two-volume set takes an in-depth look at stress signaling in plants from a uniquely genomic and proteomic perspective and offers a comprehensive treatise that covers all of the signaling pathways and mechanisms that have been researched so far. Currently, plant diseases, extreme weather caused by climate change, drought and an increase in metals in soil are amongst the major limiting factors of crop production worldwide. They devastate not only the food supply but also the economy of a nation. With global food scarcity in mind, there is an urgent need to develop crop plants with increased stress tolerance so as to meet the global food demands and to preserve the quality of our planet. In order to do this, it is necessary to understand how plants react and adapt to stress from the genomic and proteomic perspective. Plants adapt to stress conditions by activating cascades of molecular mechanisms, which result in alterations in gene expression and synthesis of protective proteins. From the perception of the stimulus to the transduction of the signal, followed by an appropriate cellular response, the plants employ a complex network of primary and secondary messenger molecules. Cells exercise a large number of noticeably distinct signaling pathways to regulate their activity. In order to contend with different environmental adversities, plants have developed a series of mechanisms at the physiological, cellular and molecular levels that respond to stress. Each chapter in this volume provides an in-depth explanation of what we currently know of a particular aspect of stress signaling and where we are heading. Together with the highly successful first volume, Stress Signaling in Plants: Genomics and Proteomics Perspective, Volume 2 covers an important aspect of plant biology for both students and seasoned researchers.

Oxidative Stress. --- Plant Genetics & Genomics. --- Plant cellular signal transduction. --- Life sciences. --- Proteomics. --- Oxidative stress. --- Plant genetics. --- Life Sciences. --- Plants --- Effect of stress on --- Molecular aspects. --- Plant molecular biology --- Cellular signal transduction --- Plant cellular control mechanisms --- Cytology. --- Plant Genetics and Genomics. --- Genetics --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Molecular biology --- Proteins --- Oxidation-reduction reaction --- Stress (Physiology)