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This volume serves as a comprehensive and useful guide for ENT and allergy physicians in the recognition, diagnosis, and treatment of patients who suffer from sinus headaches and migraines. The text reviews key issues such as identification and management of migraine, and appropriate surgical and nonsurgical treatment that is often not part of ENT or allergy resident training. With 20% of women and 6% of men having migraines (only 50% recognized) this text also serves to expand management options to physicians already medically or surgically treating sinuses or seeing cosmetic patients with head and neck concerns. Other forms of intervention in migraineurs, such as surgery, Botulinum Toxin injections and adjunctive and integrative therapy, are covered. Sinus Headache, Migraine, and the Otolaryngologist will be an invaluable resource for ENT and allergy specialists, and any physician or medical professional with an interest in sinus headache or migraine.

Medicine. --- Allergy. --- Otorhinolaryngology. --- Medicine & Public Health. --- Allergology. --- Migraine. --- Sinusitis. --- Otolaryngology. --- Ear, nose, and throat diseases --- ENT diseases --- Otorhinolaryngology --- Paranasal sinuses --- Rhinosinusitis --- Migraine headache --- Sick headache --- Inflammation --- Medicine --- Headache --- Cluster headache --- Diseases --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E

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This well-illustrated book is a comprehensive guide to the cutaneous clinical presentations of mycobacterial infections. The Mycobacterium genus includes over 170 species, nontuberculous mycobacteria (NTM) having been added to the obligate human pathogens such as M. tuberculosis and M. leprae. NTM are widely distributed in the environment with high isolation rates worldwide; the skin is a major target with variable clinical manifestations. A current  resurgence in tuberculosis is aggravated by the synergy with human immunodeficiency virus, the breakdown of health care systems, and the rise in multidrug-resistant disease, as the incidence of leprosy remains stable, at around 250,000 new cases annually, regardless of effective antibiotic therapy. Presentations  of various cutaneous infections caused by mycobacteria may be overlooked by clinicians owing the lack of familiarity with tuberculosis, leprosy, and the related  NTM clinical features. This handy guide will help  the dermatologist to spot the different clinical manifestations, make a prompt diagnosis, and apply effective treatment.

Mycobacterial diseases. --- Skin --- Infections. --- Medicine. --- Allergy. --- Dermatology. --- Infectious diseases. --- Tropical medicine. --- Medicine & Public Health. --- Allergology. --- Infectious Diseases. --- Tropical Medicine. --- Mycobacterial disease --- Mycobacterial infections --- Mycobacterioses --- Mycobacterium infections --- Gram-positive bacterial infections --- Emerging infectious diseases. --- Diseases, Tropical --- Hygiene, Tropical --- Medicine --- Public health, Tropical --- Sanitation, Tropical --- Tropical diseases --- Medical climatology --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Diseases

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Allergy is developing into one of the most prevalent diseases affecting individuals in the very early days of life. While the cause of this epidemic is still unclear, it appears that the westernized life style is playing an important role, which includes nutrition, possibly air pollution as well as hygienic conditions. While epidemiologic studies were able to narrow down these factors, basic research discovered novel mechanisms that control the organism´s tolerance against allergens. Particularly interesting is the role of microorganisms that colonize or infect a host and thereby cause damage and immunological activation followed by sensitization or exacerbation of already existing sensitizations. However at the same time microbial activation of the immune system can help to generate a protective immunity that prevents allergen sensitization. The current book is collecting these evidences and connects epidemiologic and clinical mechanistic knowledge. Only the synthesis of this knowledge will help to find solutions to the ongoing allergy epidemic in terms of public health activities, prevention and therapy.

Allergy --- Prevention. --- Medicine. --- Immunology. --- Molecular biology. --- Allergy. --- Infectious diseases. --- Biomedicine. --- Allergology. --- Infectious Diseases. --- Molecular Medicine. --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Health Workforce

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This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. This leap in assay sensitivity and specificity has led to three major advances in patient management: discrimination between primary allergic sensitization and complex cross-reactivity, recognition of IgE profiles for certain allergens and identification of patients most likely to benefit from allergen-specific immunotherapy. The book discusses in detail the benefits and limitations of this 21st century technology, and offers suggestions for the use of molecular allergology in routine clinical practice. It is a “must read” for physicians treating allergic patients as well as scientists interested in natural allergic molecules and their interactions with the human immune system.

Medicine. --- Allergy. --- Dermatology. --- General practice (Medicine). --- Respiratory organs --- Otorhinolaryngology. --- Pediatrics. --- Medicine & Public Health. --- Allergology. --- Pneumology/Respiratory System. --- General Practice / Family Medicine. --- Diseases. --- Paediatrics --- Pediatric medicine --- Ear, nose, and throat diseases --- ENT diseases --- Otorhinolaryngology --- Respiratory diseases --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Clinical sciences --- Medical profession --- Medicine --- Children --- Skin --- Immunologic diseases --- Immunoglobulin E --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Diseases --- Health and hygiene --- Pneumology. --- Family medicine. --- Family practice (Medicine) --- General practice (Medicine) --- Physicians (General practice) --- Respiratory organs—Diseases. --- Otolaryngology.

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Primary immunodeficiency diseases (PIDs) are a group of inborn disorders of the immune system, characterized by increased susceptibility to infections, autoimmunity, and cancers. Although PIDs were previously considered rare conditions, the number of diagnosed cases is growing rapidly, and about 300 different forms of PIDs have already been recognized. Nevertheless, because of inadequate medical awareness, misdiagnosis or late diagnosis occurs in a significant number of patients, leading to avoidable morbidity and mortality. The first edition of this practical reference textbook was widely welcomed by scientists and clinicians from around the world. This new edition has been extensively revised to reflect advances in knowledge and includes various PIDs not previously covered. For each disease, information is provided on definition, etiology, clinical manifestations, diagnosis, and management. Every effort has been made to ensure that, throughout, the text is easy to read and readily comprehensible. The book will represent an ideal resource for specialists when engaging in diagnosis, clinical decision-making, and treatment planning. It will also prove invaluable for doctors in training and other physicians and nurses who wish to learn more about PIDs.

Immunology. Immunopathology --- Paediatrics --- Allergy --- Human genetics --- Infectious diseases. Communicable diseases --- immunologie --- medische genetica --- genetica --- pediatrie --- besmettelijke ziekten --- allergieën --- Pediatrics. --- Immunology. --- Emerging infectious diseases. --- Allergy. --- Human genetics. --- Immunologic Deficiency Syndromes --- Genetic Diseases, Inborn --- diagnosis. --- therapy. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Immunobiology --- Life sciences --- Serology --- Pediatric medicine --- Medicine --- Children --- Diseases --- Health and hygiene --- Infectious diseases. --- Infectious Diseases. --- Allergology. --- Human Genetics. --- Diseases. --- Medical genetics. --- Medical Genetics. --- Clinical genetics --- Heredity of disease --- Medical sciences --- Pathology --- Genetic disorders --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Epidemiology --- Health --- Sick --- Genetic aspects