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LAB : building a home for scientists
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ISBN: 9783037784976 3037784970 Year: 2017 Publisher: Zürich Lars Müller Publishers

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Laboratories are both monasteries and space stations, redolent of the great ideas of generations past and of technologies to propel the future. Yet standard lab design has changed only little over recent years. Here Mark Fishman describes how to build labs as homes for scientists, to accommodate not just their fancy tools, but also their personalities. This richly illustrated book explores the roles of labs through history, from the alchemists of the Middle Ages to the chemists of the 19th and 20th centuries, and to the geneticists and structural biologists of today.


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Solving big problems : science and technology at Oak Ridge National Laboratory.
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Year: 2017 Publisher: [Oak Ridge, Tenn.] : UT-Battelle : U.S. Department of Energy, Office of Science,

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The big humanities : digital humanities/digital laboratories
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ISBN: 9781317692928 9780415748810 9780415748827 9781317692911 9781315777252 Year: 2017 Publisher: London Routledge

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This book provides an accessible introduction to, and overview of, the digital humanities, one of the fastest growing areas of literary studies. Lane takes a unique approach by focusing on the technologies and the new environment in which the digital humanities largely takes place: the digital laboratory. The book provides a brief history of DH, explores and explains the methodologies of past and current DH projects, and offers resources such as detailed case studies and bibliographies. Further, the focus on the digital laboratory space reveals affiliations with the types of research that have traditionally taken place in the sciences, as well as convergences with other fast-growing research spaces, namely innovation labs, fabrication labs, maker spaces, digital media labs, and change labs. The volume highlights the profound transformation of literary studies that is underway, one in which the adoption of powerful technology – and concomitantly being situated within a laboratory environment – is leading to an important re-engagement in the arts and humanities, and a renewed understanding of literary studies in the digital age, as well as a return to large-scale financial investment in humanistic research. It will be useful to students and teachers, as well as administrators and managers in charge of research infrastructure and funding decisions who need an accessible overview of this technological transformation in the humanities. Combining useful detail and an overview of the field, the book will offers accessible entry into this rapidly growing field.


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Recommendations of the Commission to Review the Effectiveness of the National Energy Laboratories : hearing before the Subcommittee on Energy, Committee on Science, Space, and Technology, House of Representatives, One Hundred Fourteenth Congress, first session, November 18, 2015.
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Year: 2017 Publisher: Washington : U.S. Government Publishing Office,

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The big humanities : digital humanities/digital laboratories
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ISBN: 1317692918 0415748828 1315777258 Year: 2017 Publisher: Milton Park, Abingdon, Oxon ; New York, NY : Routledge,

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"This book offers an accessible introduction to the digital humanities, one of the fastest growing areas of literary studies. Lane's unique approach focuses on the technologies and new environment in which the DH largely takes place: the digital laboratory. He provides a brief history of DH, explains the methodologies of past and current DH projects, and offers detailed case studies and bibliographies. The focus on the digital laboratory space reveals affiliations with the research that has traditionally taken place in the sciences, as well as convergences with other fast-growing research spaces like innovation labs, fabrication labs, maker spaces, digital media labs, and change labs"--Provided by publisher.


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Utilisation du MALDI-TOF MS en laboratoire de microbiologie en routine : performances et perspectives d'avenir
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Year: 2017 Publisher: Bruxelles: UCL. Faculté de pharmacie et des sciences biomédicales,

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Au laboratoire de microbiologie de routine, le MALDI-TOF MS est devenu, depuis les années 2010, un outil incontournable pour l'identification de bactéries sur gélose. Il devance les méthodes conventionnelles notamment par sa rapidité, son exactitude et sa robustesse, et est bien plus rentable que celles-ci et la biologie moléculaire. En effet, il permet une identification dans la minute, et présente actuellement un taux d'identification à l'espèce autour de 95%. Des études récentes témoignent de taux de 98,2% pour les bactéries aérobies Gram-négatif, 70,2% pour les coques Gram-négatif exigeants, 94,7% pour les coques Gram­ positif, 83,7% pour les bacilles Gram-positif, 92,5% pour les bactéries anaérobies et 98,8% pour les levures. De plus, la distinction entre pneumocoque et streptocoques mitis/oralis et shigella et E. Coli, qui constituaient deux principales limitations, ont pu être surmontées. D'autre part, la seconde partie de ce travail se consacre aux autres domaines d'application du MALDI-TOF MS en microbiologie, en routine. Premièrement, il permet l'identification directe de bactéries d'hémocultures positives, avec un taux d'identification à l'espèce d'environ 80%. Enfin, le MALDI-TOF MS peut être appliqué à la détection de résistances aux antibiotiques, pouvant donner un résultat après 2 à 5 h, contre 18 à 24 h pour un antibiogramme. Mais les méthodes utilisées pour cela nécessitent encore davantage de validations et de standardisation avant d'être implantées en routine. Since the past seven years, the MALDI-TOF MS technology has become an unavoidable tool for bacterial identification of gelose cultures in clinical microbiology. It is among other factors more accurate, way less time-consuming, more robust than conventional methods, and more cost-effective than them and molecular biology methods as well. In fact, it allows a minute identification, and currently presents an identification rate about 96% at the species level. Recent studies show rates of 98.2% for aerobic Gram-negative bacteria, 70.2% for fastidious Gram-negative rods, 94.7% for Gram-positive cocci, 83.7% for Gram-positive rods, 92.5% for anaerobes and 98.8% for yeast. Moreover, the differentiation between Pneumococcus and Streptococcus mitis/oralis and between Shigella spp. And E. coli, two major limitations of the system, can be overcome. The second part of this work focuses on the other applications of MADI-TOF MS in routine microbiology. First of all, it enables direct identification from positive blood culture bottles, with and honorable rate of identification at the species level about 80%. Finally, it can be used for the detection of antibiotic resistance, which can give results within 2 to 5 hours, versus 18 to 24 hours with an antibiogram. However, the methods used to this purpose need more validations and standardization yet to be suitable for routine use.


Book
Out of the lab and on the market : how sony computer science labs (SonyCSL) turn research into profits
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ISBN: 1315116502 135165182X Year: 2017 Publisher: Boca Raton, FL : CRC Press,

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"Tetsu Natsume of Sony Computer Science Labs (Sony CSL) has been pioneering technology promotion for a decade. As he seeks marketplace opportunities for ground-breaking research, he plays the role of a Technology Producer -- a role that will be increasingly important as organizations seek optimally efficient and effective applications of basic research. Natsume's task has been greatly facilitated by his association with Sony CSL, a research lab founded by co-author Mario Tokoro. While CSL is owned by SONY, it nevertheless operates almost entirely independently. At CSL, a diverse, cosmopolitan group of talented researchers are free to explore any idea that might one day change the world. Natsume's task is to optimise that process by identifying the best path to the market for the new insights that pour out of CSL. Functioning somewhat like a movie producer, Natsume has blazed a trail for technology promoters the world over. He explains his techniques for overcoming challenges and embracing opportunities. His "10 core principles of technology promotion", which offer the reader an especially valuable framework for moving between the very different worlds of the lab and the marketplace, cover the importance of appropriate timing, speed, commitment and mindset, while being rigorously simple and boldly ambitious.This book is an eye-opening primer for anyone interested in realising and optimising the commercial value of basic research."--Provided by publisher.


Book
DOE for the 21st century : science, environment, and national security missions : hearing before the Subcommittee on Oversight and Investigations of the Committee on Energy and Commerce, House of Representatives, One Hundred Fourteenth Congress, second session, February 24, 2016.
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Year: 2017 Publisher: Washington : U.S. Government Publishing Office,

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Biological safety : principles and practices
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ISBN: 9781555816209 1555816207 Year: 2017 Publisher: Washington, DC : ASM Press,

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Biological safety and biosecurity protocols are essential to the reputation and responsibility of every scientific institution, whether research, academic, or production. Every risk - no matter how small - must be considered, assessed, and properly mitigated. If the science is not safe, it is not good science. Now in its fifth edition, Biological Safety: Principles and Practices remains the most comprehensive biosafety reference. This book presents the guiding principles of laboratory safety, including the identification, assessment, and control of the board variety of risks encountered in laboratories, production facilities, classrooms, and other unique environments. Specifically, Biological Safety covers: protection and control elements, ranging from biological safety cabinets and personal protection systems to workplace practices and decontamination methods; administrative controls in biorisk management, including regulations, guidelines, and compliance; various aspects of risk assessment, including bacterial, viral, mycotic, zoonotic, and molecular agents; protozoa and helminths; viral vectors, allergens, and toxins; and decontamination, aerobiology, occupational medicine, and training topics. A resource for biosafety professionals, instructors, and those who work with pathogenic agents in any capacity, Biological Safety is also a critical reference for laboratory managers and those responsible for managing biohazards in a range of settings, including basic and agricultural research, clinical laboratories, the vivarium, field study, insectories, and greenhouses. -- from back cover.

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