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Dissertation
The effect of orthodontic treatment on the development of third molars
Authors: --- ---
Year: 2017 Publisher: Leuven KU Leuven. Faculteit Geneeskunde

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The effect of headgear on upper third molars: a retrospective longitudinal study. Objectives: To investigate the effects of orthodontic non-extraction treatment with or without headgear on the position of and the space available for upper third molars in growing children with class II malocclusions. Materials and methods: The sample consisted of pre– and posttreatment panoramic radiographs and lateral cephalograms of 294 class II orthodontic patients. 160 were treated with headgear, 134 were treated without headgear. The space available for the upper third molar was measured on the lateral cephalogram as the distance from pterygoid vertical (PTV) to the distal surface of the upper first molar crown (PTV-M1). Angulation, vertical position and tooth development stage of the upper third molars were evaluated on panoramic radiographs. All measurements were evaluated statistically. Results: In both groups PTV-M1 increases, but the increase in PTV-M1 was significantly higher for patients treated without headgear. A linear model for repeated measures revealed that this difference is still significant after correction for age, gender and molar occlusion. Further, there is no evidence that the change in angulation, vertical position and development stage of the upper third molars during orthodontic treatment is influenced by headgear therapy. Conclusion: This study indicates that the use of headgear in growing patients significantly affects the space available for upper third molars. However, orthodontic treatment with headgear does not influence the angulation, vertical position and development stage of upper third molars. It is therefore important to always take into account third molars during treatment planning. The effect of first and second premolar extractions on third molars: a retrospective longitudinal study. Objectives: to analyze the effect of first and second premolar extractions on eruption space for upper and lower third molars and on third molar position and angulation during orthodontic treatment. Methods: the sample consisted of 296 patients of which 218 patients were orthodontically treated without extraction and 78 patients with extraction of first or second premolars. The eruption space for third molars was measured on pre– and posttreatment lateral cephalograms, whereas the angulation, vertical position, the relation with the mandibular canal and the mineralization status of third molars were evaluated using pre– and posttreatment panoramic radiographs. All data were statistically analyzed. Results: the increase in eruption space and the change in vertical position of upper and lower third molars significantly differed between patients treated with and without premolar extractions, whereas the change in angulation, relationship with the mandibular canal and mineralization status of the third molars did not significantly differ between patients treated with and without premolar extractions. Conclusions: The retromolar space and the position of third molars significantly change during orthodontic treatment in growing patients. Premolar extractions have a positive influence on the eruption space and vertical position of third molars, whereas they do not influence the angular changes of third molars. Clinical significance: This study stresses the importance of considering the possible effects of orthodontic treatment on third molars during treatment planning.

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Dissertation
A comprehensive craniofacial study in children with 22q11.2 deletion syndrome AND 3D imaging of soft and hard facial tissues in patients with craniofacial syndromes: a systematic review
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Year: 2017 Publisher: Leuven KU Leuven. Faculteit Geneeskunde

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1. The 22q11.2 deletion syndrome (22q11.2DS) is one of the most frequent microdeletion syndromes and presents with a highly variable phenotype. In most affected individuals, specific but often subtle facial features can be observed. Here we aim to thoroughly investigate the craniofacial and dental features of 20 children with a confirmed diagnosis of 22q11.2DS by analyzing 3D facial surface scans, 2D clinical photographs, panoramic and cephalometric radiographs and dental casts. 3D facial scans were compared to scans of a healthy control group and analyzed using a spatially-dense geometric morphometric approach. Cephalometric radiographs were digitally traced and measurements were compared to existing standards. Occlusal and dental features were studied on dental casts and panoramic radiographs. Interestingly, a general trend of facial hypoplasia in the lower part of the face could be evidenced with the 3D facial analysis in children with 22q11.2DS compared to the controls. Cephalometric analysis confirmed a dorsal position of the mandible to the maxilla in 2D and showed an enlarged cranial base angle. Measurements for molar occlusion, overjet and overbite did not differ significantly from standards. Four of the 20 patients presented with tooth agenesis. Despite individual variability, we observed a retruded lower part of the face, a tubular nose, a small mouth and an increased lower facial height as common features and we also found a significantly higher prevalence of tooth agenesis in our cohort of 20 children with 22q11.2DS. Furthermore, 3D facial surface scanning proved to be an important non-invasive, diagnostic tool to investigate external features and the underlying skeletal pattern. 2. Aim: To systematically review the existing literature about 3D imaging in patients with craniofacial syndromes, evaluate its quality and propose some recommendations for future research. Method: PubMed, Embase and Cochrane databases were electronically searched. Inclusion criteria were patients with craniofacial syndromes and 3D imaging of facial soft and/or hard tissues. Exclusion criteria contained of non-genetical conditions, injury or trauma, facial soft and hard tissues not included in the image analysis, case reports, reviews, opinion articles. No restrictions were made for patients’ ethnicity or age, publication language or publication date. Study quality was evaluated using the Methodological Index for Non-Randomized Studies (MINORS). Results: The search yielded 2124 citations of which 113 were assessed in detail and 57 were eventually included in this review. Studies showed a large heterogeneity in study design, sample size and patient age. An increase was observed in the amount of studies with time and the imaging method most often used was CT. The most studied craniofacial syndromes were Treacher Collins, Crouzon and Apert syndrome. The articles could be divided into three main groups: diagnostic studies, evaluation of surgical outcomes and evaluation of imaging techniques. MINORS scores ranged from 3 to 11 over 16 for non-comparative studies and from 10 to 18 over 24 for comparative studies. Conclusion: The general quality of the included articles was moderate to low and prospective, controlled trials with sufficiently large study groups are lacking. To improve the quality of future studies in this domain and given the low incidence of craniofacial syndromes, more prospective multi-center controlled trials should be set up.

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Dissertation
Short-term hard and soft tissue changes after mandibular advancement surgery in Class II patients: a retrospective cephalometric study AND Three-dimensional aesthetic assessment in Class II patients before and after orthognathic surgery and its relation with quantitative surgical changes
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Year: 2017 Publisher: Leuven KU Leuven. Faculteit Geneeskunde

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Short-term hard and soft tissue changes after mandibular advancement surgery in Class II patients: a retrospective cephalometric study Aim: The aim of this study was to describe hard and soft tissue changes after mandibular advancement surgery and to investigate the possible differences between Class II facial patterns. Materials and methods: Lateral cephalograms of 109 patients who underwent combined orthodontic treatment and bilateral sagittal split osteotomy (BSSO) were studied. Radiographs were taken within 6 weeks before surgery (T0) and at least 6 months postoperatively (T1). Patients were classified into 3 groups according to the preoperative mandibular plane angle. Hard- and soft-tissue changes were analyzed with an x-y cranial base coordinate system. Measurements were evaluated statistically. Results: Soft and hard tissues of the chin moved forward and downward. The position of the upper lip remained unchanged, while the lower lip moved forward and upward and decreased in thickness. The soft tissue points of the chin follow their corresponding skeletal points almost completely, while the change of the lower lip was only 76 % of the movement of the underlying hard tissue. The increase of SNB was more evident in the low-angle group, as well as improvement of the facial convexity. Stomium superius moved more forward in the low- and medium- angle cases. Ratios of hard and soft tissue changes showed no differences for different facial patterns. Limitations: Limitations derived from the retrospective study design. Only short-term changes could be addressed. The distinction between surgical changes and changes due to skeletal relapse is difficult to assess. Also, the difficulty to reproduce a relaxed lip position during imaging may influence our results. Conclusion: Class II characteristics improved after mandibular advancement. Soft tissues of the chin follow their skeletal structures almost in a 1:1 relationship, while movement of the lower lip was less predictable. The facial pattern of Class II patients should be considered in treatment planning. Three-dimensional aesthetic assessment in Class II patients before and after orthognathic surgery and its relation with quantitative surgical changes The aim of this study was to compare the aesthetic outcome of Class II orthognathic patients evaluated on 3D facial images by observers with varying expertise and to examine the relationship of esthetic ratings relation with quantitative surgical changes. Pre- and post-operative 3D facial images of 20 surgically treated Class II patients (7 males, 13 females) were aesthetically assessed by orthodontists, maxillofacial surgeons and laypeople. Attractiveness of lips, chin and overall facial aesthetics were evaluated on a 5-point Likert scale. Correlation between obtained aesthetic scores and quantitative surgical changes was examined. In all groups of observers, a significant improvement of attractiveness scores was found, especially when assessing the chin. Orthodontists perceived greatest improvement, laypeople the smallest. Overall, laypeople scored higher with less variability but with a lower intra- and inter-observer agreement. No significant correlation was found between aesthetic improvement and soft tissue surgical changes. To avoid patient dissatisfaction, it is important to bear in mind that demands and perception of aesthetic improvement after orthognathic surgery are higher for clinicians than for the general public.

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