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Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic Aspects provides the reader with an overview of current knowledge about Sjogren's Syndrome. The book summarizes the huge amount of literature concerning related advances in genetic background, pathogenesis, clinical picture, and therapeutic approaches. It integrates basic immunology concepts, clinical aspects, and pharmacological issues. Scientific progress has allowed us to unmask novel pathogenic mechanisms, to perform genome wide studies, and to identify clinical and serological features associated with different disease subsets and, eventually, different disease prognoses. In addition, the increasing knowledge about SS pathogenesis provides the rationale to employ targeted therapies in SS as has already occurred in rheumatoid arthritis and systemic lupus erythematosus.

Sjogren's syndrome. --- Sjogren's Syndrome --- Sjogren Syndrome --- Sicca Syndrome --- Sjogrens Syndrome --- Syndrome, Sicca --- Syndrome, Sjogren's --- Gougerot-Sjogren's syndrome --- Sicca syndrome --- Keratoconjunctivitis sicca --- Rheumatoid arthritis --- Salivary glands --- Diseases

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In this volume devoted to systemic lupus erythematosus (SLE) and Sjögren syndrome, leading specialists from different disciplines present the latest research findings on many aspects of the diseases and describe the most recent trends in treatment, such as the “treat to target” approach. Both basic science and clinical medicine are addressed, with emphasis on the most promising clinical and laboratory-based studies. The coverage is comprehensive in scope, encompassing, for example, epidemiology, pathogenesis, autoantibodies and biomarkers, disease manifestations, involvement of different organs or systems, relationships with other disorders, biological therapy of SLE, and systemic treatment of Sjögren syndrome. Readers will find this first volume of Connective Tissue Disease to be an excellent source of information on the current understanding of, and clinical approach to, SLE and Sjögren syndrome that clearly conveys the progress made in recent years.

Nephrology. --- Musculoskeletal System Diseases --- Medicine --- Health & Biological Sciences --- Connective tissues --- Sjogren's syndrome. --- Systemic lupus erythematosus. --- Diseases. --- Libman-Sacks disease --- Lupus (Systemic lupus erythematosus) --- Lupus erythematosus, Systemic --- Lupus erythematosus disseminatus --- SLE (Disease) --- Gougerot-Sjogren's syndrome --- Sicca syndrome --- Autoimmune diseases --- Blood-vessels --- Collagen diseases --- Skin --- Rheumatology --- Keratoconjunctivitis sicca --- Rheumatoid arthritis --- Salivary glands --- Diseases --- Rheumatology. --- Monoclonal antibodies. --- Antibodies. --- Internal medicine --- Kidneys --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning --- Joints --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins