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Human beings are subjected to ageing both intrinsically and extrinsically. Rejuvenation molecule market distiguishes between invasive and non invasive means.Within invasive means, the most common molecules are botulinium toxin and hyaluronic acid.Within « cosmétics », anti-ageing method combines appropriate moisturising with an adequate renewal. Furthermore, since oxidation in behind intrinsec and extrinsec ageing, there are numerous antioxidants preparatio (vitamins A, C, E . . .).Finally, it is possible to resort to oral vitamins and antioxidants supplementation. Fighting against skin ageing cannot be effective without a healthy lifestyle L'Homme est soumis au vieillissement à la fois de manière intrinsèque et de manière extrinsèque. Le marché des molécules de rajeunissement distingue les moyens invasifs et non invasifs.Dans les moyens invasifs,les molécules les plus utilisées sont la toxine botulique et l'acide hyaluronique.Dans les « cosmétiques » la base de l'anti-âge associe une hydratation adéquate de la peau à un renouvellement cellulaire adéquat. De plus, l'oxydation étant à la base du vieillissement aussi bien intrinsèque que extrinsèque, o rencontre de nombreux anti-oxydants dans les préparations topiques (Vitamine A, C, E ...).Enfin il est possible de se tourner vers une supplémentation en vitamines et anti-oxydants par voie orale. La lutte contre le vieillissement cutané passe surtout par les bases d'une hygiène de vie correcte.
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Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.
ageing --- satellite cell --- pericytes --- fibrosis --- myogenesis --- muscular dystrophies --- rejuvenation --- epigenetics --- muscle wasting --- sarcopenia --- ageing --- satellite cell --- pericytes --- fibrosis --- myogenesis --- muscular dystrophies --- rejuvenation --- epigenetics --- muscle wasting --- sarcopenia
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Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.
ageing --- satellite cell --- pericytes --- fibrosis --- myogenesis --- muscular dystrophies --- rejuvenation --- epigenetics --- muscle wasting --- sarcopenia
Choose an application
Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.
ageing --- satellite cell --- pericytes --- fibrosis --- myogenesis --- muscular dystrophies --- rejuvenation --- epigenetics --- muscle wasting --- sarcopenia
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