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book (13)


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English (13)


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2016 (13)

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Frontiers in Clinical Drug Research - Alzheimer Disorders Volume 5.
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ISBN: 1681082314 9781681082318 Year: 2016 Publisher: Sharjah Bentham Science Publishers

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Intracellular consequences of amyloid in alzheimer's disease
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ISBN: 012804330X 0128042567 9780128043301 9780128042564 Year: 2016 Publisher: Amsterdam, [Netherlands] : Academic Press,

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Alzheimer's disease
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ISBN: 1634840410 9781634840415 9781634840323 Year: 2016 Publisher: New York

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Research progress in Alzheimer's disease and dementia.
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ISBN: 1634852060 9781634852067 9781634851725 1634851722 Year: 2016 Publisher: New York

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Developing therapeutics for Alzheimer's disease : progress and challenges
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ISBN: 0128021640 012802173X 9780128021644 9780128021736 Year: 2016 Publisher: London : Academic Press,

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Provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer's disease, along with the major hurdles that still must be overcome and potential solutions to these problems.


Book
Practical Pharmacology for Alzheimer’s Disease
Authors: --- --- ---
ISBN: 3319262041 3319262068 Year: 2016 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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The wide acceptance of the amyloid cascade hypothesis has led to vigorous development of disease-modifying drugs for Alzheimer’s disease, such as amyloid vaccinations and gamma- or beta-secretase inhibitors. However, the fact that clinical trials of these drugs have not yet yielded satisfactory results has meant that for the time being patients continue to be treated only with symptomatic drugs. Currently, four such drugs are available: donepezil, galantamine, rivastigmine, and memantine. In this book, the four leading experts on each of these drugs explain their practical pharmacology with the aim of providing a sound basis for their use, which to date has been of questionable proficiency. In addition, an introductory chapter considers the basic theory of pharmacology for Alzheimer’s disease and the book closes with an overview of the ways in which symptomatic drugs are used for dementia.


Book
Therapeutic Potentials of Curcumin for Alzheimer Disease
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ISBN: 3319158880 3319158899 Year: 2016 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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Curcumin is a yellow–orange pigment obtained from the plant Curcuma longa. The powdered rhizome of this plant, called turmeric, is a common ingredient in curry powders and has a long history of use in traditional Asian medicine. Thus, curcumin has been used extensively in Ayurvedic medicine (Indian system of medicine) and Chinese traditional medicine for centuries as a antinociceptive, antiinflammatory, and antishock agent to relieve pain and inflammation. Epidemiological studies have revealed that in India, where dietary curcumin is consumed daily in the form of curry than in the United States, the morbidity rate attributed to Alzheimer disease (AD) for Indian elders (70–79 years old) is 4.4 times lower compared to the same age group of Americans. Furthermore, elderly healthy individuals who consume curry more frequently show better cognitive performance than senior who do not consume curry. Curcumin has been extensively investigated for treating AD over decades in animal model of AD, where curcumin crosses blood brain barrier and neural cell membranes and mediates its antioxidant, antiinflammatory, antiamyloidogenic , antiangiogenic, antiproliferative, antiapoptotic, metal chelating effects leading to retardation of signal transduction pathways associated with oxidative stress and neuroinflammation. Thus, curcumin fulfills the characteristics for an ideal neuroprotective agent for AD with its low toxicity, affordability, and easy accessibility. However, poor bioavailability of curcumin is the major hurdle for its more widespread use in animals and humans. The bioavailability of curcumin can be increased by encapsulation of curcumin into liposomes, cyclodextrin, curcumin conjugate with PLGA, complexation with phospholipids, and synthesis of curcumin analogs. This monograph is the first to describe neurochemical potentials of curcumin for the treatment of AD. This monograph presents readers with cutting edge and comprehensive information on the effect of curcumin on visceral organs and brain. It is hoped that this monograph will be useful to postgraduate students, faculty, research scientists, nutritionists, and physicians, who are curious signal transduction processes associated with antioxidant, antiinflammatory, antiamyloidogenic , antiangiogenic, antiproliferative, and antiapoptotic effects of curcumin on the brain. .


Book
Alzheimer’s Turning Point : A Vascular Approach to Clinical Prevention
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ISBN: 3319340565 3319340573 Year: 2016 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer's disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia. Alzheimer’s Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease. .


Book
Memory loss, Alzheimer's disease, and dementia
Authors: ---
ISBN: 9780323316101 0323316107 9780323286619 0323286615 0323316115 Year: 2016 Publisher: Edinburgh

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Now presented in full color, this updated edition of Memory Loss, Alzheimer's Disease, and Dementia is designed as a practical guide for clinicians that delivers the latest treatment approaches and research findings for dementia and related illnesses. Drs. Budson and Solomon - both key leaders in the field - cover the essentials of physical and cognitive examinations and laboratory and imaging studies, giving you the tools you need to consistently make accurate diagnoses in this rapidly growing area. Access in-depth coverage of clinically useful diagnostic tests and the latest treatment appr


Book
Alzheimer's disease : life course perspectives on risk reduction
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ISBN: 0124171540 0128045388 9780124171541 9780128045381 Year: 2016 Publisher: Amsterdam : Elsevier,

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Alzheimer's Disease: Lifecourse Perspectives on Risk Reduction summarizes the growing body of knowledge on the distribution and causes of Alzheimer's disease (AD) in human populations, providing the reader with knowledge on how we define the disease and what its risk and protective factors are in the context of a life-course approach. At the conclusion of the book, the reader will understand why Alzheimer's disease likely begins at conception, then progresses through early-life and adult risk factors that ultimately impact the balance between pathologic insults in the brain and the ability of the brain to modify disease symptoms. In contrast to edited volumes that may have little cohesion, this book focuses on an integrated life-course approach to the epidemiology of dementia, in particular, Alzheimer's disease.

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