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Providing a comprehensive review of short-and long-term adverse events of both antiresorptive and anabolic drugs, this practical guide updates the clinician on the pathophysiology of osteoporosis and the principles behind our present and future pharmaceuticals. Leading practitioners in the field examine all current literature and data regarding the duration and safety of these therapies, with recommendations for clinicians on decision-making and best practices for osteoporosis patients. An overview of the pathophysiology and epidemiology of osteoporosis and discussion of both anabolic and antiresorptive drugs is followed by fracture risk assessment and an examination of treatment failures. Next, a number of chapters are dedicated to the diagnosis, presentation and management of atypical femur fractures and osteonecrosis of the jaw (ONJ), each of which are significant patient concerns when using these osteoporosis treatments. The introduction and utilization of drug holidays is also discussed, as well as the long-term outlook for management of osteoporotic patients. Written and edited by experts in the field, The Duration and Safety of Osteoporosis Treatment is a balanced resource for researchers, practitioners and policy-makers alike for clinical decision-making and patient care.
Pathological endocrinology --- Orthopaedics. Traumatology. Plastic surgery --- endocrinologie --- osteoporose --- orthopedie --- fracturen
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This second edition brings together the latest information about the pathophysiology and new therapeutic alternatives for osteoporosis of advanced age. Written by highly recognised clinicians and basic scientists in the field of aging bone research, this book includes aspects of muscle and bone interaction focusing on the impact of age-related muscle loss (sarcopenia) on the pathogenesis of falls and fractures in older persons. Osteoporosis in Older Persons- Advances in Pathophysiology and Therapeutic Approach, Second Edition, aids the reader in understanding the mechanisms of senile osteoporosis with a practical approach to the treatment of its consequences. It is the perfect reference guide for geriatricians, gerontologists and bone biologists, as well as medical trainees. .
Geriatrics --- Orthopaedics. Traumatology. Plastic surgery --- osteoporose --- geriatrie --- orthopedie --- fracturen --- gerontologie
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The aim of this book is to review the latest findings on musculoskeletal disease associated with diabetes. It has been increasingly recognized that maintaining skeletal health is an important factor in achieving longevity in healthy subjects. Diabetes has been established as a disease independently associated with sarcopenia and increased risk of bone fracture resulting from osteoporosis; therefore, it is reasonable to maintain that musculoskeletal health is important in preserving good health. As either bone or muscle is intimately involved in the regulation of metabolic status, keeping the musculoskeletal system healthy is important for improving abnormal glucose metabolism toward normal levels and is vital, as well, for maintaining normal activities of daily living. Muscle is a target of insulin for enhancing the entry of glucose; thus it is conceivable that sarcopenia and muscle containing fat streaks causes insulin resistance in diabetic patients. Furthermore, bone is an organ that regulates Ca and Pi levels in serum by releasing or resorbing Ca and Pi to and from bone tissue. It is now known that bone is a definitive endocrine organ for regulating glucose metabolism and Pi metabolism by secreting osteocalcin and FGF-23 from osteocytes/osteoblasts. Readers will learn of the recent findings in this area, and this book will benefit physicians who deal with diabetes, particularly orthopedists and bone specialists, as well as all physical therapists.
Pathology of the metabolism --- Pathological endocrinology --- diabetes mellitus --- osteoporose --- fracturen
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From a reassessment of osteoporosis to contributing factors, clinical applications of antiosteoporotic agents, and rehabilitation, this book examines various aspects of the disease and its treatment. Edited and written from an orthopedic perspective, it approaches osteoporosis as both a metabolic disease and a locomotive syndrome. As orthopedic surgeons in Japan are responsible for pharmacotherapy, surgery, and pain control, the authors pursue a comprehensive approach, focusing especially on the effect on muscles and on fracture operation rather than expanding the scope to bone density. Osteoporosis in Orthopedics provides extensive content and insights for clinicians, researchers, medical students, and post-docs specializing in osteoporosis. It also offers a valuable resource for orthopedic and spine surgeons who need extensive knowledge of osteoporosis and bone metabolism in the context of patient care.
Pathology of the metabolism --- Orthopaedics. Traumatology. Plastic surgery --- osteoporose --- metabolische ziekten --- orthopedie --- fracturen
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This dictionary provides a comprehensive list of the terms and definitions commonly used in clinical rheumatology and osteology, and the new edition has been extended to include more than 50 additional entries. The book contains systematic descriptions relating to diseases of the locomotor apparatus, including osteoporosis, and important laboratory findings; special reference is made to the immunological parameters, which are essential for correct definition of rheumatologic disorders. Another focus is the general principles of pharmacological treatment, including biologicals and modern therapy. Information is also provided on individual disorders in the field of mineral metabolism and metabolic osteopathies and basic issues in rheumatic surgery. General entries are included from the fields of physical medicine and physiotherapy, including a system of functional assessment. The Dictionary of Rheumatology will be of value for medical students and all who are training in this specialty. .
Allergy --- Pathology of the organs of movement --- Infectious diseases. Communicable diseases --- farmacologie --- osteoporose --- reumatologie --- besmettelijke ziekten --- allergieën
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This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.
Molecular biology --- Physiology: reproduction & development. Ages of life --- Geriatrics --- veroudering (biologie) --- dementie --- osteoporose --- geriatrie --- astma --- artritis --- gerontologie --- moleculaire biologie
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This book uniquely combines cutting-edge medical, psychological, and sociocultural topics pertinent to eating disorders. In the medical realm, the book focuses on Eating Disorders’ newly investigated associations with ADHD and sleep disorders, and on innovative treatments of osteoporosis in anorexia nervosa. Novel contributions in the psychological realm address families’ trans-generational transmission of Eating Disorders-related difficulties and novel internet-based treatments for such families. Lastly, in the sociocultural realm, the book discusses social contagion and Pro-Ana websites as increasing risk for disordered eating in young women around the globe. This volume provides readers with more holistic perspectives of each realm and their interplay, to promote Eating Disorders’ understanding, treatment, prevention, and research. It provides various professionals including mental health providers, physicians, nutritionists, and graduate students in these professions.
Sociology --- Hygiene. Public health. Protection --- Psychiatry --- preventieve gezondheidszorg --- sociologie --- osteoporose --- gezondheidspromotie --- ADHD (attention deficit hyperactivity disorder) --- klinische psychologie
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This book focuses on the analysis and treatment of osteoporotic bone based on drug administration, tracking fatigue behavior and taking into consideration the mechanical interaction of implants with trabecular bone. Weak trabeculae are one of the most important clinical features that need to be addressed in order to prevent hip joint fractures.
Social policy and particular groups --- Biomathematics. Biometry. Biostatistics --- Molecular biology --- Human biochemistry --- Orthopaedics. Traumatology. Plastic surgery --- Applied physical engineering --- Engineering sciences. Technology --- Programming --- Artificial intelligence. Robotics. Simulation. Graphics --- neuronale netwerken --- fuzzy logic --- klinische chemie --- medische biochemie --- cybernetica --- bio-informatica --- heupen --- biochemie --- osteoporose --- chirurgie --- orthopedie --- fracturen --- rehabilitatie --- biometrie --- sociale integratie --- KI (kunstmatige intelligentie) --- ingenieurswetenschappen --- mechanica --- moleculaire biologie --- AI (artificiële intelligentie)
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