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Lupus erythematosus. --- Autoimmune diseases.

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The correct intake of a medical treatment is key to therapeutic success. The in-depth analysis of the causes of non –adherence is often required to prevent after-effects on health, including at the social and economic levels. Systemic lupus erythematsous (SLE) is a chronic disease, for witch this topic is very well documented. Innovative methods of non-adherence detection exist for dispensary and hospital use. For patients suffering from SLE, a method of choice is blood concentrations measurement of drug products having a long half-life such as hydroxychloroquine. This method allows for increased awareness of physicians and pharmacists, who are often unaware of the behavior of their patients. However, other detection methods are available at the pharmacies that are less constraining for the patient and easier to use. Based on a survey conducted in several pharmacies, I have highlighted the importance of the role of the pharmacist in terms of education, guidance and therapeutic follow-up. Moreover, thanks to a witness report and clinical data received from the Cliniques Universitaires Saint-Luc, this master thesis allows to state that the non-adherence of SLE patients is a problem that not only affects patient’s health, but also his quality of life. That’s why numerous studies need to be realized in the future to improve the means of screening and management strategies of chronically ill patients. La prise correcte d'un traitement médicamenteux constitue la clé du succès thérapeutique et l'analyse approfondie des causes de la non-adhérence est souvent nécessaire afin de prévenir les répercutions aussi bien en terme de santé qu'au niveau social et économique. Le lupus érythémateux disséminé est une pathologie chronique très documentée sur ce sujet et possède des méthodes de détection intéressantes aussi bien en milieu officinal qu'en milieu hospitalier. Une des méthodes de choix chez un patient atteint du LED est la mesure des concentrations sanguines des médicaments de longue demi-vie tel que l'hydroxychloroquine. Cette méthode permet une prise de conscience des médecins et des pharmaciens, souvent naïfs vis-à-vis des comportements de leurs patients. Cependant d'autres méthodes de détection moins contraignantes pour le patient et plus faciles d'emploi sont également utilisées en milieu officinal. Grâce à un sondage réalisé dans différentes officines, j'ai mis en évidence l'importance du rôle du pharmacien en termes d'éducation, de conseils et de suivi thérapeutique. De plus, ce mémoire m'a permis, grâce à un témoignage et à des données cliniques obtenues aux Cliniques Universitaires Saint-Luc, d'affirmer que la non-adhérence des patients atteints du LED est une véritable réalité qui porte atteinte non seulement à la santé et mais aussi à la qualité de vie du patient. C'est pourquoi, de nombreuses études devront donc être menées dans l'avenir afin de perfectionner aussi bien les mesures de détection que les stratégies pour améliorer la gestion des traitements des patients atteints de maladies chroniques.

Chronic Disease --- Lupus Erythematosus, Discoid

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Systemic lupus erythematosus --- Alternative treatment. --- Diagnosis. --- Lupus Erythematosus, Systemic --- Libman-Sacks disease --- Lupus (Systemic lupus erythematosus) --- Lupus erythematosus, Systemic --- Lupus erythematosus disseminatus --- SLE (Disease) --- Autoimmune diseases --- Blood-vessels --- Collagen diseases --- Skin --- Diseases --- Biomarkers. --- physiopathology. --- Biochemical Marker --- Biologic Marker --- Biologic Markers --- Clinical Marker --- Immune Marker --- Immune Markers --- Immunologic Marker --- Laboratory Marker --- Marker, Biochemical --- Marker, Biological --- Marker, Clinical --- Marker, Immunologic --- Marker, Laboratory --- Marker, Serum --- Marker, Surrogate --- Serum Marker --- Surrogate End Point --- Surrogate End Points --- Surrogate Endpoint --- Surrogate Endpoints --- Surrogate Marker --- Viral Marker --- Biochemical Markers --- Biological Markers --- Clinical Markers --- Immunologic Markers --- Laboratory Markers --- Markers, Biochemical --- Markers, Biological --- Markers, Clinical --- Markers, Immunologic --- Markers, Laboratory --- Markers, Serum --- Markers, Surrogate --- Markers, Viral --- Serum Markers --- Surrogate Markers --- Viral Markers --- Biological Marker --- End Point, Surrogate --- End Points, Surrogate --- Endpoint, Surrogate --- Endpoints, Surrogate --- Marker, Biologic --- Marker, Immune --- Marker, Viral --- Markers, Biologic --- Markers, Immune --- Molecular Probes --- Endophenotypes --- Libman-Sacks Disease --- Lupus Erythematosus Disseminatus --- Systemic Lupus Erythematosus --- Disease, Libman-Sacks --- Libman Sacks Disease --- Biomarker

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Lupus nephritis. --- Kidneys --- Diseases. --- Kidney diseases --- Nephritis --- Nephropathy --- Renal diseases --- Lupus glomerulonephritis --- Glomerulonephritis --- Renal manifestations of general diseases --- Systemic lupus erythematosus