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Genome Stability: From Virus to Human Application covers the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, with the latter including major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, as well as changes in genome stability in response to aging. Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. This book teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. The book also covers how epigenetic factors contribute to genome stability and how species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner.

Genomics. --- Genomes. --- Genetics --- Genomics --- Haploidy --- Genome research --- Genomes --- Molecular genetics --- Research --- DNA Repair. --- Genomic Instability. --- Epigenesis, Genetic. --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Epigenome --- DNA Methylation --- Genome Instability --- Genome Stability --- Genomic Stability --- Genome Instabilities --- Genome Stabilities --- Genomic Instabilities --- Genomic Stabilities --- Instabilities, Genome --- Instabilities, Genomic --- Instability, Genome --- Instability, Genomic --- Stabilities, Genome --- Stabilities, Genomic --- Stability, Genome --- Stability, Genomic --- Chromothripsis --- DNA Sequence, Unstable --- Base Excision Repair --- Excision Repair --- Nucleotide Excision Repair --- Base Excision Repairs --- Excision Repair, Base --- Excision Repair, Nucleotide --- Excision Repairs --- Nucleotide Excision Repairs --- Repair, Base Excision --- Repair, Excision --- Repairs, Base Excision --- DNA-Formamidopyrimidine Glycosylase --- DNA Repair Enzymes --- Targeted Gene Repair

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This book provides surgical tips, pearls and pitfalls of the ten most common surgical procedures performed by elbow surgeons in their daily clinical practice. It is written by some of the most recognized elbow surgeons in the world and follows a homogeneous format so the reader can easily grasp the key points. A very high quality of  pictures depicting the surgical steps, together with representative drawings is one of the main strengths of this book. After reading this concise and practical guide, the reader will feel confident in performing basic surgical procedures around the elbow, knowing where the risks are and improving the technique to achieve an optimal results for patients.

Medicine. --- Orthopedics. --- Medicine & Public Health. --- Surgical Orthopedics. --- Elbow --- Surgery. --- Excision of elbow --- Orthopedic surgery. --- Operative orthopedics --- Orthopedics --- Surgery, Operative --- Orthopaedics --- Orthopedia --- Surgery

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This text provides a comprehensive, contemporary review of this disease and serves as an important resource for clinicians and researchers with an interest in medullary thyroid cancer. The book reviews the initial management of the patient with thyroid nodules, including risk factors, appropriate genetic evaluation of suspected/known medullary thyroid cancer, and appropriate screening for diseases associated with inherited forms of medullary thyroid cancer, including primary hyperparathyroidism and pheochromocytomas. It includes an in-depth discussion of the optimal surgical management of patients with sporadic and inherited disease, those with locoregional metastases, distant metastases, and recurrent medullary thyroid cancer. The long-term follow-up and management of patients with medullary thyroid cancer is highlighted. Medullary Thyroid Cancer will serve as a useful resource for all providers and researchers interested in this relatively rare and challenging malignancy. It highlights recent guidelines for the management of patients with medullary thyroid cancer and discusses controversies within the literature. All chapters are written by experts in the field and incorporate multiple disciplines, including Surgery (Endocrine Surgery, General Surgery, and Otolaryngology), Endocrinology, Radiology, Medical Oncology and Genetic Counseling.

Medicine. --- Endocrinology. --- Surgery. --- Surgical oncology. --- Medicine & Public Health. --- General Surgery. --- Surgical Oncology. --- Thyroid gland --- Cancer. --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Surgery, Primitive --- Medicine --- Internal medicine --- Hormones --- Excision --- Treatment --- Endocrinology .

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Beginning with the scientific basis of tumors, this book provides up-to-date information on epidemiology, cytogenetics, and molecular biology, before examining current treatments for the full range of pediatric tumors. Integration of surgery, neoadjuvant and adjuvant chemotherapy, and radiation therapy is a dominant theme. In addition, chapters on supportive care, palliative care, and the role of parents’ associations reflect the book's holistic approach to treating children with cancer. The  Surgery of Childhood Tumors is written by world-renowned international authorities on pediatric cancer from major children's cancer groups in the UK, Europe, and the US. Contributors discuss geographical variations in treatment for each type of tumor. Excellent full-color pictures and line drawings illustrate all aspects of managing childhood tumors, including details of operative techniques which are neglected in many other texts. This comprehensive book provides a contemporary approach for pediatric, general, and urological surgeons dealing with childhood tumors. Since the second edition, the book has been significantly expanded and updated in order to encompass the very latest developments and strategies in pediatric surgical oncology.

Medicine. --- Pediatric surgery. --- Surgical oncology. --- Medicine & Public Health. --- Pediatric Surgery. --- Surgical Oncology. --- Tumors --- Tumors in children --- Surgery. --- Pediatric oncology --- Children --- Diseases --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Surgery, Primitive --- Medicine --- Excision --- Treatment --- Pediatric surgery --- Surgery, Pediatric

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This text provides a comprehensive update on the management of various cancers as interpreted by recognized experts in the field. In addition, each chapter will focus on current controversies and areas of advance. These advances have brought major changes to cancer care and have surfaced new dilemmas in clinical decision-making. Modern cancer management requires an understanding of the current status of a diverse array of oncologic diseases. The text is designed to assist the practicing surgeon in achieving optimal management of encountered oncologic problems. Current Controversies in Cancer Care for the Surgeon will be an invaluable resource for clinical surgeons, surgeons in training, students and researchers.  .

Surgery - General and By Type --- Surgery & Anesthesiology --- Health & Biological Sciences --- Cancer --- Tumors. --- Surgery. --- Neoplasms --- Tumours --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Excision --- Pathology --- Cysts (Pathology) --- Oncology --- Treatment --- General Surgery. --- Surgery, Primitive --- Medicine